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PBRC 2009
Metabolic Syndrome: Overview
Metabolic Syndrome is not a disease, but rather a cluster of disorders of your body’s
metabolism, including:
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Signs and Symptoms
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Metabolic Syndrome
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Prevalence
Age The prevalence of metabolic syndrome increases with age, affecting less than 10% of people in
their 20s and 40% of people in their 60s.
Race Metabolic syndrome is generally more common among blacks and Mexican-Americans than
among Caucasians.
Obesity A body mass index (BMI) greater than 25 increases your risk of metabolic syndrome and
abdominal obesity increase the risk of MS. Abdominal obesity refers to having an apple
shape rather than a pear.
History of Having a family history of type 2 diabetes or diabetes during pregnancy (gestational diabetes)
diabetes increases the risk for developing metabolic syndrome.
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When is it time to seek medical advice?
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Prevention
Healthy lifestyle changes can prevent the onset of the syndrome.
Get moving
o It is important to stay active. Get at least 30 minutes of moderately
strenuous activity on most days of the week is recommended.
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Diagnosing Metabolic Syndrome
According to the National Cholesterol Education Program (NCEP), the presence of
three or more of the following traits indicates metabolic syndrome:
Waist Circumference
o Greater than 35 inches in women and 40 inches in men (abdominal obesity)
Triglyceride
o Levels of 150 milligrams per deciliter (mg/dl) or higher
Blood Pressure
o 130/85 millimeters of mercury or higher
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Treatment
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Treatment
It is common for your doctor to routinely monitor the following to ensure that
lifestyle modifications are working:
o Weight
o Blood glucose
o Cholesterol
o Blood pressure
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Self-care
Although metabolic syndrome creates a real risk for developing diabetes, stroke or heart disease,
these conditions can be prevented. Insulin resistance can be controlled by the following:
Lose weight
o Losing as little as 5 to 10% of your body weight can reduce insulin levels and high
blood pressure, thus reducing your risk of diabetes.
Exercise
o Walking just 30 minutes a day or engaging in other aerobic activities can help
prevent the serious diseases associated with MS.
Stop smoking
o Smoking cigarettes increases insulin resistance and worsens health
consequences associated with MS.
Eat fiber-rich foods
o Whole grains, beans, fruits and vegetables are high in dietary fiber.
These are important foods to eat since dietary fiber is known to
lower insulin levels.
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Treatment
Medications to control the syndrome’s individual risk factors include:
Weight Along with diet and exercise, it may be necessary to prescribe weight loss drugs.
loss drugs Two commonly prescribed weight-loss drugs include sibutramine (Meridia) and
orlistat (Xenical).
Insulin In individuals with diabetes, doctors often prescribe thiazolidinediones and metformin
sensitizers (Glucophage, Glucophage XR) to decrease insulin resistance. These medications may
also be useful in improving insulin metabolism in individuals with MS.
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Treatment
Medications to control the syndrome’s individual risk factors include:
Aspirin Aspirin is often prescribed to help reduce the risk for a heart attack.
Medications Major types of medications used to control high blood pressure include diuretics,
to lower angiotensin-converting enzymes (ACE) inhibitors, calcium channel blockers and
blood beta blockers.
pressure
Medications Medications such as niacin, statins and fibrates can help improve cholesterol in the
to regulate following ways:
cholesterol By reducing the level of low-density lipoprotein (LDL) cholesterol (“bad” cholesterol)
By increasing the level of high-density (HDL) cholesterol (“good” cholesterol)
By decreasing the level of triglycerides (Another “bad” component of cholesterol)
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Division of Education
Phillip Brantley, PhD, Director
Pennington Biomedical Research Center
Claude Bouchard, PhD, Executive Director
Heli J. Roy, PhD, RD
Shanna Lundy, BS
Beth Kalicki
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Edited: October 2009
About Our Company
The Pennington Biomedical Research Center is a world-renowned nutrition research center.
Mission:
To promote healthier lives through research and education in nutrition and preventive medicine.
The Pennington Center has several research areas, including:
Clinical Obesity Research
Experimental Obesity
Functional Foods
Health and Performance Enhancement
Nutrition and Chronic Diseases
Nutrition and the Brain
Dementia, Alzheimer’s and healthy aging
Diet, exercise, weight loss and weight loss maintenance
The research fostered in these areas can have a profound impact on healthy living and on the prevention of common chronic
diseases, such as heart disease, cancer, diabetes, hypertension and osteoporosis.
The Division of Education provides education and information to the scientific community and the public about research
findings, training programs and research areas, and coordinates educational events for the public on various health issues.
We invite people of all ages and backgrounds to participate in the exciting research studies being conducted at the
Pennington Center in Baton Rouge, Louisiana. If you would like to take part, visit the clinical trials web page at
www.pbrc.edu or call (225) 763-3000.
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Sites
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