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Antigen-125 in
Tuberculosis
Jennifer , MCP Wongkar
Introduction
Diagnosis :
Bacteriological + clinical examination
Pulmonary TB :
& Radiological (X-Ray)
Other methods to Dx
Hypothesis
1. Activation of the inflammatory cascade by M.TB
abnormal proliferation on mesothelial cells, causing
an ↑ in CA-125.
2. Surface antigen of mycobaterium have same cell
epitope membrane of the tumor marker CA-125.
Immunohistochemistry
Granulomas of TB associated w/ inflammation & proliferati
on of mesothelium ↑ production & secretion of CA-125
showed CA-125 formed a fine line around the granuloma
CA-125 & Tuberculosis
After the discovery of CA-125 in TB, many other studies
reported that tumor marker CA-125, CA-199, & carcino
embryonic antigen (CEA) found to be higher in
patients with TB than in the normal population.
P<0.001
Yilmaz et al.
Ca125 is beneficial in determination of
TB activity & in diferentiation between active & i
nactive pulmonary TB
Kanagarajan et al.
CA-125 Levels appear to be associated with :
- number of bacillary highest in miliary TB &
pulmonary TB with cavities.
CA-125 & Tubeculosis Activity
Not effective
Monitoring therapeutic response in extrapulmonal TB
CA-125
Parameter that needs to be taken into account in
determining the activity of the disease
because CA-125
can also be elevated in
both benign conditions or cancer
Summary
• Elevated levels of CA-125 is found in both pulmonary TB and
extrapulmonary TB involving serous tissues