Академический Документы
Профессиональный Документы
Культура Документы
OSTEOARTHRITIS
Pembimbing : Oleh :
Letkol CKM dr. Maksum Pandelima, Sp.OT Faridatul Afifah (17710042)
Cell destruction
M e m b r a n e p h o s ph o l i p i d s
A r a ch i d o n i c a c i d
Cox-1, cox-2
IL-1 and metalloproteases have been found to
play an important role in cartilage destruction.
PRIMARY OA SECONDARY OA
P R I M A RY O A SECONDARY OA
Female Mechanical forces: scoliosis,
Cartilage Biomechanical
Properties Problems
Morphology of
Primary OA Primary Generalized OA
STRUCTURE OF JOINT
CARTILAGE
Collagen (type 2)
Proteoglycan
-Hyaluronic acid
-Glycoseaminoglycan
Water
Condrocyte
Regeneration and Degeneration
Osteophyte
Eburnation
s
Subcondral
Fibrillation
cysts
PATHOLOGY
OF
OSTEOARTH
RITIS
LABORATORY RADIOLOGIC
FINDINGS OF OA FINDINGS OF OA
T he r e a r e n o p a th o g n o m o n i c Na r r o wi n g o f j o i n t sp a c e
laboratory findings for OA ( d u e t o l o ss o f c a r ti l a g e )
L a b o r a t o r y a n a l ys i s i s O s t eo p h y te s
p e r f o r m e d f o r d i f f e re n t i a l Subchondral (paraarticular)
diagnosis sc l e r o si s
B o n e c ys ts
RADIOLOGIC GRADE OF OA
G1 normal
G2 mild
G3 m o d e ra t e
G4 s e ve r e
CLINICAL R A D IO L O GI C
F IN D I N G S F IN D I N G S
J o i n t p a i n - d e g e n er a ti v e
S t i f f n e s s f o l l o w i n g i n ac ti vi t y – 3 0 m i n
L i m i t a ti o n o f RO M – l a t e r s t a ge s
D e f o r m i ty – r e s t r i c i t i o n o f A D L
Radiologic finding grade 1 - 4
TREATMENT
Symptomatic Surgical
Structure
modifying