MCQ- Genetics-2

A woman with one gene for hemophilia and one gene for color
blindness on one of the X chromosomes marries a normal man. Which
of the following statements is true
regarding their children?

A. All the sons and daughters are hemophilic and color blind
B. All daughters are hemophilic and color blind
C. All sons are hemophilic and color blind
D. 50% sons hemophilic and color blind
E. 50% daughters hemophilic and color blind
1
MCQ- Neoplasia-1

A study is performed to analyze characteristics of malignant neoplasms in

biopsy specimens. The biopsies were performed on patients who had
palpable mass lesions in breast. Of the following microscopic findings, which
is most likely to indicate that the neoplasm is malignant?

A. Invasion
B. Necrosis
C. Pleomorphism
D. Increased mitotic figures
E. Increased nuclear/cytoplasmic ratio

2
MCQ- Neoplasia-2

Which of the following is least likely to be used as a means of distinguishing

a benign from a malignant neoplasm?

A. Degree of cellular differentiation

B. Rate of growth
C. Type and amount of necrosis
D. Evidence of metastasis
E. Encapsulation
3
MCQ- Neoplasia-3

A 48-year-old man was diagnosed with chronic myeloid leukemia. Cytogenetic

analysis of cells obtained via bone marrow aspiration. Which of the following
genetic lesion is most likely to be seen in this case?

A. Hetrozygosity of P53
B. Amplification of MYC
C. BCR-ABL fusion
D. Loss of APC
E. Mutation of K-RAS
4
MCQ- Neoplasia-4

A clinical study is performed of oncogenesis in human neoplasms. It is

observed that some neoplasms appear to develop from viral oncogenesis,
with serologic confirmation of past viral infection. Which of the following
neoplasms is most likely to arise in this manner?

A. Retinoblastoma
B. Osteosarcoma
C. Cervical carcinoma
D. Prostatic adenocarcinoma
E. Basal cell carcinoma of skin
5
MCQ- Neoplasia-5

A 60-year-old man has had a chronic cough for the past year. He is a non-
smoker. A chest x-ray demonstrates a 5 cm perihilar mass. A sputum sample
showed presence of atypical cells suggestive of squamous cell carcinoma.
Which of the following environmental exposures is most likely to be
associated with these findings?

A. Silica
B. Radon
C. Asbestos
D. Benzene
E. Formaldehyde

6
MCQ- Genetics-3

In a man, which of the following genotypes may be correct result of

aneuploidy in sex chromosomes?

A. 22 pairs + XY
B. 22 pairs + XX
C. 22 pairs + XXY
D. 22 pairs + XXXY
E. 22 pairs + XXXX

Dr. Khurshid 7
MCQ- Genetics-3

A 65-year-old male presents to his physician for complaints of fatigue.

He reports feeling tired during the day over the past 4 months.
Complete blood cell count reveals the following: WBC 6000/uL.0,
hemoglobin 9.0 g/dL, hematocrit 27.0 %, and platelets 350000/uL. Mean
corpuscular volume is 72 fL. Iron studies demonstrate a ferritin of 20
ng/ml (N: 30-300). Of the following, which is the next best step?

A. Bone marrow biopsy

B. Blood transfusion
C. Stool examination
D. Reassure the patient
E. Colonoscopy

Dr. Khurshid 8
MCQ- Hematology-1

A 50-year-old male presents to his physician for complaints of fatigue.

He reports feeling tired during the day over the past 4 months.
Complete blood cell count reveals the following: WBC 6000/uL.0,
hemoglobin 9.0 g/dL, hematocrit 27.0 %, and platelets 350000/uL. Mean
corpuscular volume is 72 fL. Iron studies demonstrate a ferritin of 20
ng/ml (N: 30-300). Of the following, which is the next best step?

A. Bone marrow biopsy

B. Blood transfusion
C. Stool examination
D. Reassure the patient
E. Colonoscopy

Dr. Khurshid 9
MCQ- Hematology-3
A 30-year-old woman presents to her physician with a 3-month history
of fatigue. She denies any recent history of fevers, chills or headaches.
A CBC demonstrates a microcytic anemia. Her Iron studies show:
Serum iron: 35 µg/dL (normal 50–170 µg/dL);
TIBC: 225 µg/dL (normal 250–370 µg/dL);
Transferrin saturation: 8% (normal 15–50%);
Serum ferritin: 200 µg/L (normal 15-150 µg/L);

Which of the following is the most likely cause of this patient's

symptoms and laboratory findings?

A. Glucose 6PD deficiency

B. Beta thalassemia minor
C. Fibroid uterus
D. Rheumatoid arthritis
E. Hook worm infestation

Dr. Khurshid 10
MCQ- Hematology-4
A 55-year-old man has become increasingly fatigued for the past 10
months. On physical examination there are no abnormal findings.
Laboratory studies show his Hb is 9.2 g/dL, Hct 27.9%, MCV 120 fL,
platelet count 112x109/liter, and WBC count 4.5x109/liter. Peripheral
smear is shown in the picture. Which one of the following mechanism of
the disease best describes the pathogenesis of the disease in this
patient?

A. Bone marrow fibrosis

B. Clonal stem cell abnormality
C. Defective heme synthesis
D. Impaired DNA synthesis
E. Immune destruction of circulating erythrocytes 11
Dr. Khurshid
MCQ- Hematology-2

A 50-year-old male presents to his physician for complaints of fatigue

and burning sensation in tongue for which he occasionally chews ice.
On physical examination his conjunctivae are pale and his nails show
kilonychia. Peripheral smear is shown in the picture. His iron studies
will show;

A. High serum iron level

B. Decrease TIBC
C. Increase serum ferritin
D. Decrease transferrin saturation
E. Normal RDW

Dr. Khurshid
12
MCQ- Genetics-4

The pedigree chart shown is an example of ;

A. Autosomal recessive disorder

B. Autosomal dominant disorder
C. X-linked recessive disorder
D. X-linked dominant disorder
E. Y-linked dominant disorder
Dr. Khurshid 13
“Nearly all men can stand adversity,
but if you want to test a man's
character, give him power!”
— Abraham Lincoln