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•Kwashiorkor
• Marasmus
DEFINITION
It refers to a range of clinical
manifestations that result from
inadequate intake of proteins
and calories required to meet the
daily needs of the body
Pathogenesis
• From physiological point of view, proteins of the
body can be considered to exist in two different
compartments within the body
– Somatic compartment – in skeletal muscles
– Visceral compartment – proteins present in visceral
organs.
• Two poles of PEM are
– Kwashiorkor
– Marasmus
• In marasmus, somatic compartment is depleted
more
• In kwashiorkor, predominantly the visceral
compartment gets affected.
Kwashiorkor Vs Marasmus
Both diseases tend to occur more commonly in children
Marasmus Kwashiorkor
• If the child is malnourished with • When protein
equitable deficiency of both proteins deficiency is relatively
and calories, he is likely to develop greater than total
marasmus. caloric intake,
kwashiorkor is the
• Somatic protein compartment is more likely
depleted more, with preservation of manifestation.
the more vital visceral protein
compartment. Hence the disease is • There is severe
less serious as compared to depletion of visceral
kwashiorkor. protein compartment.
Opportunistic infections.