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DRUG DELIVERY
SYSTEM
PRESENTED BY:
Puja Kumari (Bph/10010/15)
Harish Kumar (Bph/10011/15)
Dilshad Shahid (Bph/10012/15)
• These are smart, intelligent, environmental sensitive polymeric systems showing
response in specific environment related to certain stimulus.
• They also provide controlled release of drugs at the desired pathological site.
• Upon application of counter trigger, they have the ability to come back to their
original physical state.
The triggers can be:
Internal triggers – The internal environment of the system in which the drug
delivery system is induced such as ph, temperature, ionic environment, proteins,
carbohydrates.
Fig.:
Various types of stimulus are:
• They usually modify the energy level of the • They modulate the molecular interactions –
polymer/solvent system. Example: light, between polymer and solvent molecules, or
temperature, ultrasound, etc. between polymer chains.
Biological Stimuli:
Conformational changes of
the polymer.
c. Polymeric nanocomposites: E.g. Polymeric blend of PVA & GUAR GUM using
nanoclay as filters
This type of chemically activated system permits targeting the delivery of drug only in
the region with selected pH range.
Categorization of stimuli-responsive polymers
2. Cross linked gels: More cross linking results in decreased swelling and deswelling.
The hydrogels responds rapidly to small changes in pH and temperature and has
been shown to also respond to a change in light intensity, ionic strength, magnetism,
inflammation, ultrasound and certain biochemicals (e.g. Glucose,
1. Swelling Tests:
where,
Ws is the swollen weight, &
Wd is the dry weight of the films at time at time t.
Optimization and Evaluation of Stimuli responsive systems:
• Polymeric samples are then allowed to get soaked in prepared Congo red solution
and left for 24 hours.
• After the duration the absorbance of the solution after swelling of polymer is
recorded
3. Oscillatory Test
The influence of pH pulses are being tested on the polymeric devices and
optimization is to be done based on the systems which shows superior curve for a
prolonged period of time.
Applications: