MICROENCAPSULATION

SHUBHRAJIT MANTRY
Asst.Prof .
kottam institute of pharmacy, A.P
 INTRODUCTION

 Microencapsulation is a process by which very tiny droplets or particles

of liquid or solid material are surrounded or coated with a continuous film of

polymeric material.

 The product obtained by this process is called as micro particles, microcapsules.

 Particles having diameter between 3 - 800µm are known as micro particles or

microcapsules or microspheres.

 Particles larger than 1000µm are known as Macro particles .

 CLASSIFICATION OF MICROPARTICLE
Generally Micro particles consist of two components
a) Core material
b) Coat or wall or shell material.

1.Microcapsules: The active agent forms a core surrounded by an inert diffusion barrier.

2.Microspheres: The active agent is dispersed or dissolved in an inert polymer.

 ADVANTAGES:

 To Increase of bioavailability

 To alter the drug release

 To improve the patient’s compliance

 To produce a targeted drug delivery

 To reduce the reactivity of the core in relation to the outside environment

 To decrease evaporation rate of the core material.

 To convert liquid to solid form & To mask the core taste.

 FUNDAMENTAL CONSIDERATION:

Microencapsulation

Core material Coating material Vehicle

Solid Liquid
Polymers Aqueous Nonaqueous
Waxes

Resins
Proteins
Polysaccharides
APPLICATION OF MICROENCAPSULATION TECHNIQUES:
 Microencapsulation : Applications
Chemistry Medicine & Pharmacy &
Printing & recording vetinary
Carbonless paper,
Adhesives
Control release, Taste masking
Pigments and Vectorisation
Fillers Catalysts Artificial organs
single dose treatment
Food & feed
Aromas, Probiotics Agriculture
Unsaturated oil, Fungicide – herbicide, Insect
Enzyme food processing repellent, Biopesticide
amino acid for cows Pigments and fillers
Artificial insemination
Biotechnology &
environment Consumer & diversified
Continuous reactor, Cosmetics,
Shear protection, detergents (enzymes),
Reactor oxygenation sanitary (active, aromas)
MICROENCAPSULATION TECHNIQUES:
MICROENCAPSULATION TECHNIQUES:
1. Air suspension techniques( Wurster)
2. Coacervation process
3. Spray drying & congealing
4. Pan coating
5. Solvent evaporation
6. Polymerization
7. Extrusion
8. Single & double emulsion techniques
9. Supercritical fluid anti solvent method (SAS)
10. Nozzle vibration technology
Air Suspension Techniques( Wurster)

Microencapsulation by air suspension technique consist

of the dispersing of solid, particulate core materials in a
supporting air stream and the spray coating on the air
suspended particles. Within the coating chamber,
particles are suspended on an upward moving air stream.
The design of the chamber and its operating parameters
effect a recalculating flow of the particles through the
coating zone portion of the chamber, where a coating
material, usually a polymer solution, is spray applied to
the moving particles.
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