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• Methods :
- Age, gravidity, parity and BMI were compared using t test
- The association between endometriosis and premenstrual spotting were compared using chi
square.
- Each variable (premenstrual spotting, dysmenorrhea, dyspareunia, dyschezia, age, parity,
and bmi) and each outcome (endometriosis, rAFS stage, lesional phenotype) were indicated by
the phi-coefficient.
- The variability between self-reported premenstrual spotting and histologic findings was performed
with unweighted kappa analysis
- Statistical analysis was performed using SPSS software.
RESULTS
• There is a strong association between premenstrual spotting ≥ 2 days and the finding of
endometriosis at surgery in woman with infertility.
• Particularly advanced-stage disease (rAFS, >stage1) and the red vesicular lesion
phenotype (produce higher PGF2α than typical powder-burn implants).
• Pathophysiology : red vesicular lesion → produce high prostaglandin F (PGF2α) → exert
a luteolytic effect on the corpus luteum in the absence of pregnancy → low progesterone
→ premenstrual spotting.
DISCUSSION