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THROMBOCYTOPENIA &
RELATED DISSODERS
MARSHELL TENDEAN, DPCP
DEPARTMENT OF INTERNAL MEDICINE
THROMBOCYTOPENIA
• Antiphospholipid syndrome
• Autoimmune thrombocytopenia (eg, Evans
syndrome)
• Common variable immune deficiency
• Drug administration side effect
• Lymphoproliferative disorders
• Bone marrow transplantation side effect
• Vaccination side effect
• Systemic lupus erythematosus
*. Evans syndrome is associated with autoimmune
thrombocytopenia with coincident hemolytic anemia.
ITP GUIDELINES AND
RECOMENDATIONS
• Necessary Evaluation
• History: Isolated bleeding symptoms consistent with
thrombocytopenia without constitutional symptoms (e.g.
significant weight loss, bone pain, night sweats).
• Physical examination: Bleeding symptoms in the absence of
hepatosplenomegaly, lymphadenopathy, or stigmata of
congenital conditions.
• Complete blood count: Isolated thrombocytopenia (platelet
count <100 x 10 /L). Anemia only if due to significant
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