CANNABINOID HYPEREMESIS

SYNDROME
DARLENE PIPER
MIDTERM MINI CASE STUDY
ILLINOIS STATE UNIVERSITY DIETETIC INTERN
UNITY POINT METHODIST
 CANNABINOID HYPEREMESIS SYNDROME (CHS)

A CONDITION INCLUDING GASTRIC

PAIN AND NAUSEA, DEHYDRATION,
AND EXCESSIVE VOMITING DUE TO
CHRONIC ABUSE OF CANNABIS.
 -DIFFICULT AND COSTLY
NO BLOOD TEST TO LINK CANNABIS USE TO SYMPTOMS
NO TEST TO MEASURE THC LEVELS FROM CANNABIS USE

-CT SCANS AND LAB TESTS ORDERED

DIAGNOSIS ELIMINATION DIAGNOSIS
CYCLIC VOMITING

-USAGE AND SYMPTOM DIARY

COMPULSIVE BATHING IN HOT WATER TO EASE PAIN AND CONTROL
NAUSEA AND VOMITING
STAGES OF CHS

PRODROMAL: DAYS, MONTHS, OR YEARS

HYPEREMETIC: LENGTH OF DURATION VARIES DEPENDING

ON PT TOLERANCE

RECOVERY: LENGTH OF DURATION CAN BE ETERNAL.

SYMPTOMS TYPICALLY RETURN IF THE PERSON TRIES
CANNABIS AGAIN.
 Endocannabinoid SYSTEM (ECS)

DIRECTLY RELATED TO HEALTH AND WELLBEING BUILDING A GATEWAY BETWEEN BODY AND MIND

UTILIZES CANNABINOIDS AND CANNABINOID RECEPTORS TO PRODUCE HOMEOSTASIS WITHIN THE BODY
CANNABINOIDS

ENDO- PRODUCED NATURALLY IN THE HUMAN BODY

EX. ANANDAMIDE (AEA) AND 2-ARACHIDONOYLGLYCEROL (2-AG)

SYNTHETIC- CREATED IN A LABORATORY ENVIRONMENT
EX. MARINOL CAPSULES - SYNTHETIC FORM OF DELTA-9-THC
PHYTO- FOUND IN PLANTS
EX. MARIJUANA (CANNABIS INDICA) AND HEMP PLANTS (CANNABIS SATIVA)

ALL ACT ON CANNABINOID RECEPTORS ALTERING NEUROTRANSMITTER

RELEASE IN THE BRAIN
PHYTOCANNABINOIDS

-TETRAHYDROCANNABINOL (THC): THE MAIN PSYCHOACTIVE COMPONENT BUT ITS EXACT EFFECT
VARIES FROM PERSON TO PERSON. SCIENTIFIC STUDIES HAVE SHOWN IT HAS NEUROPROTECTIVE
PROPERTIES AND PRODUCES PAIN RELIEF.

-CANNABIDIOL (CBD): IT HAS A WHOLE RANGE OF MEDICINAL PROPERTIES. IT IS GENERALLY

CONSIDERED TO BE A NON-PSYCHOACTIVE COMPONENT THAT IS BELIEVED TO REDUCE AND CONTROL
THE PSYCHOACTIVE EFFECTS OF THC.

-CANNABINOL (CBN): HAVE A SEDATIVE EFFECT. PAIN RELIEF, ANTI-INSOMNIA, PROMOTION OF

GROWTH OF BONE CELLS, ANTIBACTERIAL, ANTI-INFLAMMATORY, ANTI-CONVULSIVE, APPETITE
STIMULANT
 THE HUMAN
ENDOCANNABINOID SYSTEM
 MODES OF CANNABIS ADMINISTRATION

SMOKING/VAPING- MOST RAPID RESULTS

ORAL PILLS- CAN TAKE UP TO THREE HOURS FOR RESULTS
TINCTURES- RAPID RESULTS

PATCHES- DIRECTLY TO THE BLOODSTREAM, BUILDS UP AND GIVES

AN EXTENDED RELEASE
TOXICITY

CB1 RECEPTORS ARE NOT PRESENT IN THE PART OF THE BRAIN THAT REGULATES HEART RATE AND
RESPIRATION, SO THERE IS NO DOSAGE THRESHOLD FOR THC

TOLERANCE IS INDIVIDUALIZED AND SOME MAY HAVE A PREDISPOSITION TO THE SYNDROME OR

THC POTENCY OR CHEMICAL MAKEUP MAY HAVE CHANGED OVER TIME

MOLD
PESTICIDES

CROSSBREEDING AND HYBRIDS OF PHYTOCANNABINOIDS HAS INCREASED

COMPLETE CESSATION HAS BEEN THE ONLY CURE FOR CHS.
QUESTIONS?
 RESOURCES

HTTPS://WWW.NCBI.NLM.NIH.GOV/PMC/ARTICLES/PMC4469074/

HTTPS://WWW.NCBI.NLM.NIH.GOV/PMC/ARTICLES/PMC4120766/

HTTPS://WWW.NCBI.NLM.NIH.GOV/PMC/ARTICLES/PMC3576702/

HTTPS://WWW.NCBI.NLM.NIH.GOV/PMC/ARTICLES/PMC3751385/

HTTPS://WWW.NCBI.NLM.NIH.GOV/PMC/ARTICLES/PMC2658859/

HTTPS://WWW-SCIENCEDIRECT-COM.LIBPROXY.LIB.ILSTU.EDU/SCIENCE/ARTICLE/PII/S1555415518301430