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Chapter 7 Lecture

General, Organic, and Biological


Chemistry: An Integrated Approach
Laura Frost, Todd Deal and Karen Timberlake
by Richard Triplett

Chapter 7
Solution Chemistry:
How Sweet Is Your Tea?

© 2011 Pearson Education, Inc.


Chapter Outline

7.1 Solutions Are Mixtures


7.2 Formation of Solutions
7.3 Chemical Equations for Solution Formation
7.4 Concentrations
7.5 Dilution
7.6 Osmosis and Diffusion
7.7 Transport Across Cell Membranes

© 2011 Pearson Education, Inc. Chapter 7 2


7.1 Solutions Are Mixtures

• A homogeneous mixture, such as a glass of tea,


is called a solution.

• Solutions consists of at least one substance,


called a solute, evenly dispersed throughout a
second substance, called the solvent.

• Components of a solution do not react with one


another.

© 2011 Pearson Education, Inc. Chapter 7 3


7.1 Solutions Are Mixtures, Continued

• Solute is the substance present in the smallest


amount.

• Solvent is the substance present in the greatest


amount.

• When sugar is added to a glass of iced tea,


sugar is the solute and water is the solvent.

• Sugar, once dissolved in a glass of iced tea, will


not come out of solution over time.
© 2011 Pearson Education, Inc. Chapter 7 4
7.1 Solutions Are Mixtures, Continued

Properties of solutions are as follows:

© 2011 Pearson Education, Inc. Chapter 7 5


7.1 Solutions Are Mixtures, Continued

Phases of Solutes and Solvents

• In addition to a solution made by adding a solid


to a liquid, a gas can be a solution also.

• For example, the air we breath is a solution in


which nitrogen is the solvent and oxygen and
other gases are the solute.

• Metals, like brass, can be a solution of solids in


solids.
© 2011 Pearson Education, Inc. Chapter 7 6
7.1 Solutions Are Mixtures, Continued

• Brass is an alloy of the solute zinc in the solvent


copper.

• The solute and solvent can either be a solid,


liquid, or gas in a solution.

• Aqueous solutions are solutions in which water


is the solvent.

© 2011 Pearson Education, Inc. Chapter 7 7


7.1 Solutions Are Mixtures, Continued

© 2011 Pearson Education, Inc. Chapter 7 8


7.1 Solutions Are Mixtures, Continued
Colloids and Suspensions

• Some solutions appear to be solutions, but are


not because they are not a transparent liquid.

• Colloids are solutions of undissolved particles


that do not separate over time. Milk is a colloid
(or colloidal mixture) because it contains
proteins and fats that do not dissolve.

• Particles in a colloid must be between 1 and


1000 nanometers in diameter.
© 2011 Pearson Education, Inc. Chapter 7 9
7.1 Solutions Are Mixtures, Continued

• Particles greater than 1000 nanometers in


diameter will separate from a mixture when
standing. These mixtures are considered
suspensions.

• Blood is considered a suspension. Blood cells


will settle in a tube upon standing because they
are greater than 1 micrometer in diameter.

• Blood cells can be separated by centrifugation,


a spinning process that accelerates settling.
© 2011 Pearson Education, Inc. Chapter 7 10
7.1 Solutions Are Mixtures, Continued

© 2011 Pearson Education, Inc. Chapter 7 11


7.2 Formation of Solutions

• Recall the golden rule of solubility, like dissolves


like, which explains why some compounds dissolve
in water and others do not.
• The dissolving process requires that individual
solvent particles surround the solute molecules and
interact through intermolecular forces or ion–dipole
attractions.
• Dissolving is a physical process, not a chemical
process because the particles are just redistributing
themselves.
• The process of dissolving is referred to as solvation
for all solutions, and more specifically, as hydration
in the case of an aqueous solution.
© 2011 Pearson Education, Inc. Chapter 7 12
7.2 Formation of Solutions, Continued

Factors Affecting Solubility and Saturated


Solutions

• The maximum amount of a solute that can


dissolve in a specified amount of solvent defines
the solubility. Solubility depends on the polarity
of the solute and solvent, and the temperature of
the solvent.

© 2011 Pearson Education, Inc. Chapter 7 13


7.2 Formation of Solutions, Continued

• An unsaturated solution does not contain the


maximum amount of solute in a given amount of
solvent.

• A saturated solution contains all the solute that


can dissolve in a given amount of solvent.

• If more solute is added to a saturated solution,


the additional solute will remain undissolved.
This solution reaches an equilibrium state
between the dissolved and undissolved solute.

© 2011 Pearson Education, Inc. Chapter 7 14


7.2 Formation of Solutions, Continued

• At equilibrium, the rate of dissolving solute is the


same as the rate of dissolved solute reforming
crystals.

• The equilibrium rates can be represented by the


following chemical equation:

© 2011 Pearson Education, Inc. Chapter 7 15


7.2 Formation of Solutions, Continued

© 2011 Pearson Education, Inc. Chapter 7 16


7.2 Formation of Solutions, Continued

• There are conditions in our body that result in


the build up of undissolved solids in bodily fluids.

• Gout occurs when uric acid crystals form in soft


tissues, or in cartilage and tendons. Kidney
stones form when compounds like calcium
phosphate or calcium oxalate build up in the
urinary tract, kidneys, urethra, or bladder.

© 2011 Pearson Education, Inc. Chapter 7 17


7.2 Formation of Solutions, Continued

© 2011 Pearson Education, Inc. Chapter 7 18


7.2 Formation of Solutions, Continued

Solubility and Temperature

• Most solids dissolve in water when the


temperature increases.

• Solubility can manipulated by changing the


temperature of a solution.

• As temperature increases in a solution


containing a gas, solubility of the gas decreases.

© 2011 Pearson Education, Inc. Chapter 7 19


7.2 Formation of Solutions, Continued

• For example, if an unopened soda can is left in a


car on a hot day, the container can explode due
to the release of carbon dioxide in solution as a
result of the elevated temperature.

• Solubility of a gas in a solution is related to


pressure and temperature.

• Solubility of a gas dissolved in water decreases


with a rise in temperature.

© 2011 Pearson Education, Inc. Chapter 7 20


7.2 Formation of Solutions, Continued

Solubility and Pressure—Henry’s Law

• Pressure affects the solubility of a gas in a liquid.

• Henry’s law states that the solubility of a gas in


a liquid is directly related to the pressure of the
gas over the liquid. That is, the amount of gas
that can dissolve in a liquid increases as the
pressure of the gas in the space above the liquid
increases.

© 2011 Pearson Education, Inc. Chapter 7 21


7.2 Formation of Solutions, Continued

• An example of Henry’s law is demonstrated


when a can of soda is opened at room
temperature and poured into a glass. The
dissolved carbon dioxide will fizz and escape
from the liquid.

• The hissing sound made when a soda is opened


is a result of the space above the beverage in
the container, which is filled with carbon dioxide
at a higher pressure than the surrounding
atmosphere. The gas then escapes quickly once
the seal is broken.
© 2011 Pearson Education, Inc. Chapter 7 22
7.2 Formation of Solutions, Continued

The amount of carbon dioxide that was


dissolved in the drink at a higher pressure will
not stay dissolved once the drink is opened at a
lower pressure.

© 2011 Pearson Education, Inc. Chapter 7 23


7.2 Formation of Solutions, Continued

• Another example of Henry’s law can be seen


when studying how the lungs remove carbon
dioxide from blood, but add oxygen.

• The pressure of carbon dioxide is higher in the


blood delivered back to the lungs than the
pressure of carbon dioxide in the lungs.
Therefore, this gas will pass out of the
bloodstream into the lungs where it can be
expired.

© 2011 Pearson Education, Inc. Chapter 7 24


7.2 Formation of Solutions, Continued

Oxygen dissolves into the blood at the lungs


because the pressure of oxygen in the air is
higher, allowing it to dissolve into the
bloodstream.

© 2011 Pearson Education, Inc. Chapter 7 25


7.3 Chemical Equations for Solution Formation
• Pure water does not conduct electricity, but tap
water will. Why is this?

• Tap water contains dissolved ions, and these


ions conduct electricity.

• Solutes that produce ions in solution are called


electrolytes.

• Ionic compounds, like NaCl, that completely


dissociate when they dissolve in water are
considered strong electrolytes.
© 2011 Pearson Education, Inc. Chapter 7 26
7.3 Chemical Equations for Solution
Formation, Continued
• Covalent compounds, like sugar, do not ionize in
solution when they dissolve, so no ions are
formed. Instead they exist as molecules.

• Soluble covalent compounds do not conduct


electricity and are referred to as
nonelectrolytes.

• Some covalent compounds will partially ionize in


water. These compounds are termed weak
electrolytes and are weak conductors of
electricity.
© 2011 Pearson Education, Inc. Chapter 7 27
7.3 Chemical Equations for Solution
Formation, Continued

© 2011 Pearson Education, Inc. Chapter 7 28


7.3 Chemical Equations for Solution
Formation, Continued
• In a chemical equation, the reactants always
appear on the left side, and the products always
appear on the right side. They are separated by
an arrow which means react to form or yield.

• A general chemical equation is shown as:

© 2011 Pearson Education, Inc. Chapter 7 29


7.3 Chemical Equations for Solution
Formation, Continued
Strong Electrolytes

• An ionic compound like magnesium chloride will


yield magnesium ions and chloride ions when
dissolved in water. This is shown in a chemical
equation as:

• Note that the number of magnesium and


chloride ions formed in the products is the same
as the number of each found in the reactant.
© 2011 Pearson Education, Inc. Chapter 7 30
7.3 Chemical Equations for Solution
Formation, Continued
• The number of ions in the product is the same
as the number of each found in the reactant.

• The law of conservation of mass states that


matter is neither created nor destroyed. Matter
merely changes form. Atoms cannot appear or
disappear.

• After writing a reaction, it is important to inspect


it to make sure that the number of each element
is the same on the product and reactant side of
the equation.
© 2011 Pearson Education, Inc. Chapter 7 31
7.3 Chemical Equations for Solution
Formation, Continued
• When the number of elements are the same on
the reactant and product side of the equation,
we say the equation is balanced.

• Subscripts that appear in formulas for


compounds and the full-size numbers in front of
particles indicate the total number of a particle
present. These full-size numbers are referred to
as coefficients.

• Balancing requires that the charge be the same


on both sides of the chemical equation.
© 2011 Pearson Education, Inc. Chapter 7 32
7.3 Chemical Equations for Solution
Formation, Continued

• In the above equation, the 2 in front of the


chloride ion indicates that there are two chloride
ions produced for every one MgCl2 that
dissociates.

• The MgCl2 has no net charge, and one Mg2+ and


two Cl- sum to a total charge of zero, so the
charges are balanced.
© 2011 Pearson Education, Inc. Chapter 7 33
7.3 Chemical Equations for Solution
Formation, Continued

• Note that the arrow points in one direction,


implying that the process is irreversible.

• The phases of matter are indicated. The


reactants will usually be a solid that dissolves,
and the products will be aqueous.

• The H2O appearing below the arrow indicates


this process occurs in water.
© 2011 Pearson Education, Inc. Chapter 7 34
7.3 Chemical Equations for Solution
Formation, Continued
Nonelectrolytes

• Nonelectrolytes are polar compounds that


dissolve in water, but do not ionize in water.

• Covalent compounds like glucose do not


dissociate.

• The phase of the product is changed to aqueous


in this type of representation.
© 2011 Pearson Education, Inc. Chapter 7 35
7.3 Chemical Equations for Solution
Formation, Continued
Weak Electrolytes

• The organic functional group that partially


ionizes in solution is the carboxylic acid.

• This functional group has an ionic form known


as the carboxylate group.

• Carboxylic acids are weak electrolytes.

© 2011 Pearson Education, Inc. Chapter 7 36


7.3 Chemical Equations for Solution
Formation, Continued
• Partial ionization of acetic acid is shown as:

• The carboxylic acid group contains a very polar


O–H bond that can dissociate to form the
carboxylate ions and H+ ions when dissolved.

• The rates of the forward and reverse reactions


equalize until the amount of acetic acid and the
ions no longer changes.
© 2011 Pearson Education, Inc. Chapter 7 37
7.3 Chemical Equations for Solution
Formation, Continued
• In the equation of the dissociation of acetic acid,
the number of atoms and the total charge on
each side is balanced.

• The phase of the weak electrolyte before


hydration may be liquid, gas, or solid.

• The steps for writing and balancing equations for


both ionic and covalent compounds are shown
on the next slide.

© 2011 Pearson Education, Inc. Chapter 7 38


7.3 Chemical Equations for Solution
Formation, Continued

© 2011 Pearson Education, Inc. Chapter 7 39


7.3 Chemical Equations for Solution
Formation, Continued
Ionic Solutions and Equivalents

• Blood and other bodily fluids contain many


different electrolytes, like Na+, K+, Cl-, and HCO3-,
as dissolved ions.

• The amount of dissolved ion can be expressed by


the equivalent (Eq).

• An equivalent relates the charge in a solution to


the number of ions or moles of ions present.
© 2011 Pearson Education, Inc. Chapter 7 40
7.3 Chemical Equations for Solution
Formation, Continued

The number of equivalents present per mole of


an ion equals the charge of that ion.
© 2011 Pearson Education, Inc. Chapter 7 41
7.4 Concentrations

• The concentration of a solution can be


expressed in different units.

• Concentration is defined as the amount of


solute dissolved in a given amount of solution.

• The denominator is the total amount of solution,


which includes the amount of solute.
© 2011 Pearson Education, Inc. Chapter 7 42
7.4 Concentrations, Continued

The units of concentration vary depending on


the type of solute. This table shows the normal
concentration ranges of some substances tested
in blood along with readable units.

© 2011 Pearson Education, Inc. Chapter 7 43


7.4 Concentrations, Continued

Milliequivalents per Liter (mEq/L)

• Electrolytes in bodily fluids are represented by


the concentration unit of milliequivalents per
liter of solution.
1000 mEq = 1 Eq

• Ionic solutions have a balance in the number of


positive and negative charges present because
the dissolving ionic compounds have no net
charge.
© 2011 Pearson Education, Inc. Chapter 7 44
7.4 Concentrations, Continued

Blood plasma has a total


electrolyte concentration of
150 mEq/L, meaning that the
total concentrations of
positive and negative ions is
150 mEq/L.

© 2011 Pearson Education, Inc. Chapter 7 45


7.4 Concentrations, Continued

Concentrations of other ionic solutions used as


intravenous fluids are shown in this table.

© 2011 Pearson Education, Inc. Chapter 7 46


7.4 Concentrations, Continued

Millimoles per Liter (mmol/L) and Molarity (M)

• Units of electrolytes are sometimes given in


mmoles/L instead of mEq/L.

• The charge on an ion is the number of


equivalents present in 1 mole.

• An ion like Na+ has a 1+ charge, so the number


of equivalents is equal to the number of moles,
and the units mmole/L and mEq/l are identical.
© 2011 Pearson Education, Inc. Chapter 7 47
7.4 Concentrations, Continued

• We can show this equivalency mathematically


by converting mEq/L to mmole/L using the
following conversion factor:

• Using this conversion factor, we can determine


the concentration of a 135 mEq/L Na+ solution in
mmole/L.

© 2011 Pearson Education, Inc. Chapter 7 48


7.4 Concentrations, Continued

• A unit related to mmole/L is used in the


laboratory to describe the concentrations of
solutions. This unit is molarity, M, which is the
number of moles of solute in 1 L of solution.

• The mole is related to the number of molecules


present by Avogadro’s number.

© 2011 Pearson Education, Inc. Chapter 7 49


7.4 Concentrations, Continued

• For example, a 3.0 M solution of substance A


will have the same number of molecules as a
3.0 M solution of substance B, even though the
masses of A and B are different.

• Molarity is used so chemists can determine how


many particles of a solute are available to react
in a chemical reaction.

• A 3.0 M solution of A will have 3.0 moles A per L


of solution.
© 2011 Pearson Education, Inc. Chapter 7 50
7.4 Concentrations, Continued

Percent (%)

Three common units that use percent are:


1. Mass/volume percent
2. Mass/mass percent
3. Volume/volume percent

© 2011 Pearson Education, Inc. Chapter 7 51


7.4 Concentrations, Continued

Math Matters: Percent (%)

• A fraction can be converted to a percent by


dividing the numerator by the denominator,
multiplying by 100, and adding a percent sign.

• A decimal number can be converted to a percent


by multiplying by 100 and adding a percent sign.

© 2011 Pearson Education, Inc. Chapter 7 52


7.4 Concentrations, Continued

Percent Mass/Mass, % (m/m)

• When using % m/m in expressing concentration,


it is important to realize that the mass of
solute + mass of solvent = mass of solution.

• Therefore, in the preparation of these solutions,


the mass of both the solute and the solvent must
be determined on a balance.

© 2011 Pearson Education, Inc. Chapter 7 53


7.4 Concentrations, Continued

• This concentration unit can be determined by:

• The unit % (m/m) is often referred to as percent


weight/weight (% wt/wt).

© 2011 Pearson Education, Inc. Chapter 7 54


7.4 Concentrations, Continued

If 8.0 g of glucose is mixed with 42.0 g of water,


the total mass of the solution is 50.0 g (8.0 g +
42.0 g). The concentration of the resulting
solution would be solved as follows:

© 2011 Pearson Education, Inc. Chapter 7 55


7.4 Concentrations, Continued

Percent Volume/Volume, % (v/v)

• This unit is typically used when liquids or gases


are the solute.

• For example, a bottle of wine that is 14% (v/v)


alcohol means that 14 mL of alcohol is present
in 100 mL of the wine.

© 2011 Pearson Education, Inc. Chapter 7 56


7.4 Concentrations, Continued

This concentration unit can be determined by:

© 2011 Pearson Education, Inc. Chapter 7 57


7.4 Concentrations, Continued

Percent Mass/Volume, % (m/v)

• This concentration unit is often used in the


preparation of intravenous fluids. Also known as
percent weight/volume (% w/v).

• For example, a solution of normal saline is 0.9%


(m/v), which means the solution contains 0.90 g
of NaCl in 100 mL of solution.

© 2011 Pearson Education, Inc. Chapter 7 58


7.4 Concentrations, Continued

This concentration unit can be determined by:

© 2011 Pearson Education, Inc. Chapter 7 59


7.4 Concentrations, Continued

Relationship to Other Common Units

• The unit for measuring hemoglobin (oxygen


carrying protein) in blood is g/dL, which is the
same as % (m/v). A dL is the same as 100 mL.

• A common unit for measuring molecules, like


glucose and cholesterol, in blood is mg/dL,
which is the same as mg% (milligram percent).

© 2011 Pearson Education, Inc. Chapter 7 60


7.4 Concentrations, Continued

Parts per Million (ppm) and Parts per Billion


(ppb)

• Parts per million and parts per billion are


concentration units for very dilute solutions.

• How small is a part per million? There are a


million pennies in $10,000, so one penny is a
ppm of $10,000. Or five drops of food coloring in
a bathtub of water is about one part per million.

© 2011 Pearson Education, Inc. Chapter 7 61


7.4 Concentrations, Continued

• How small is a part per billion? One drop of food


coloring in an Olympic size swimming pool is
about one part per billion.

• Fluoride is added to water at 4 ppm to promote


strong teeth, which means 4 g of fluoride are in
every million mL of tap water.

• The maximum contaminant level of lead in water


is 15 ppb, which means 15 g of lead are in every
billion mL of tap water.
© 2011 Pearson Education, Inc. Chapter 7 62
7.4 Concentrations, Continued

• The unit of ppm is referred to as 1 mg/L and ppb


is referred to as 1 μg/L.

• Multiplying a solution, given in g solute/mL


solution, by one million will provide a
concentration in ppm. Similarly, multiplying by
one billion will provide a concentration in ppb.

© 2011 Pearson Education, Inc. Chapter 7 63


7.4 Concentrations, Continued

© 2011 Pearson Education, Inc. Chapter 7 64


7.5 Dilution

• To prepare a solution of low concentration, you


can dilute a solution of higher concentration.

• For example, if you add water to a can of


concentrated orange juice, the amount of orange
juice does not change even though you have
more solution present.

• The amount of solute stayed the same, but the


volume increased, so the concentration of the
solution decreased.
© 2011 Pearson Education, Inc. Chapter 7 65
7.5 Dilution, Continued

• Mathematically, a dilution equation can be


expressed as seen in the following equation:

• Cinitial is the initial concentration, Cfinal is the final


concentration, Vinitial is the initial volume, and
Vfinal is the final volume. If any three of the four
are known, then the fourth can be determined.

© 2011 Pearson Education, Inc. Chapter 7 66


7.5 Dilution, Continued

For example, if 150 mL of 0.90% saline is diluted


to a final volume of 450 mL with water, what
would the concentration of the final diluted
concentration be?

© 2011 Pearson Education, Inc. Chapter 7 67


7.5 Dilution, Continued

• The dilution equation works for any


concentration unit where the amount of solution
is expressed in volume units.

• This equation will not work with % m/m.

• Dilution of pharmaceuticals are often prepared


using this dilution equation.

© 2011 Pearson Education, Inc. Chapter 7 68


7.6 Osmosis and Diffusion
Osmosis

• Aqueous solutions are found inside and outside


cells. The concentration of these solutions is
highly controlled by the cells.

• These solutions are separated by a


semipermeable membrane called the cell
membrane.

• A semipermeable membrane allows some


molecules to pass through the barrier.
© 2011 Pearson Education, Inc. Chapter 7 69
7.6 Osmosis and Diffusion, Continued

• These solutions are considered to be isotonic


solutions, meaning that the concentrations of
solutes in the solutions is the same on both
sides of the membrane.

• Let’s examine why there is a limit to the amount


of water a person can drink. A person can drink
too much water, and it is recommended that a
person drink between eight to twelve 8-ounce
glasses of water a day.

© 2011 Pearson Education, Inc. Chapter 7 70


7.6 Osmosis and Diffusion, Continued

• Individuals engaging in vigorous exercise and


infants whose formula is overly diluted can drink
too much water.

• The concentration of dissolved solutes in tap


water or dilute formula is lower than the
concentration of dissolved solutes in the body’s
internal solution, so drinking large amounts of
tap water will dilute the blood.

© 2011 Pearson Education, Inc. Chapter 7 71


7.6 Osmosis and Diffusion, Continued

• When the blood is diluted, the concentration of


solutes in the blood goes down. This causes an
imbalance in the concentration of solutes inside
and outside the cells.

• The concentration of solutes outside the cell is


low, while the concentration inside the cell is
high.

• When this happens, the solution outside the


cells is said to be a hypotonic solution.
© 2011 Pearson Education, Inc. Chapter 7 72
7.6 Osmosis and Diffusion, Continued

• When the concentrations outside and inside the


cell are different, water will travel across the cell
membrane in an attempt to equalize the
concentrations.

• The passage of water across the cell membrane


is known as osmosis.

• When an individual drinks too much water,


hyponatremia (low sodium concentration) can
occur from the bloodstream becoming dilute.
© 2011 Pearson Education, Inc. Chapter 7 73
7.6 Osmosis and Diffusion, Continued

• If too much water enters the cell in an attempt to


equalize solute concentrations, the cells will
swell up and could burst. This bursting of cells is
known as lysing.

• When water enters the cell through osmosis, the


water molecules exert a certain amount of
pressure on the membrane known as osmotic
pressure.

© 2011 Pearson Education, Inc. Chapter 7 74


7.6 Osmosis and Diffusion, Continued

If the solute concentration is more concentrated on


one side of a cell membrane, water molecules will
cross the membrane in an attempt to equalize the
concentrations on either side, and, as a result, the
higher the osmotic pressure.

© 2011 Pearson Education, Inc. Chapter 7 75


7.6 Osmosis and Diffusion, Continued

• Why does someone not want to drink salt water


to quench their thirst?

• Concentration of dissolved salts in salt water are


higher (about three times higher) than the
concentration of dissolved solutes inside the cell.

• When salt water is consumed, it draws water out


of the cells through osmosis to equalize the
concentrations. This dehydrates cells.

© 2011 Pearson Education, Inc. Chapter 7 76


7.6 Osmosis and Diffusion, Continued

• If salt water is consumed, the concentration of


solutes outside the cells is higher than those
inside the cell.

• The solution outside the cells is said to be a


hypertonic solution. During dehydration, the
cells shrivel in a process known as crenation.

© 2011 Pearson Education, Inc. Chapter 7 77


7.6 Osmosis and Diffusion, Continued

© 2011 Pearson Education, Inc. Chapter 7 78


7.6 Osmosis and Diffusion, Continued

• Consider the following illustration.

• Net flow of water is from the lower concentration


solution to the higher concentration of solution in
order to equalize the concentrations.
© 2011 Pearson Education, Inc. Chapter 7 79
7.6 Osmosis and Diffusion, Continued

• Because cell membranes are semipermeable,


osmosis is an ongoing process. This process is
used to maintain the concentrations of solutes at
about the same level inside and outside the cells.
• Solutions delivered into patients’ bloodstreams are
isotonic, which minimizes osmosis.
• Physiological solutions exert the same osmotic
pressure as the cells and are isotonic.
• Common physiological solutions are 0.90% (m/v)
NaCl, more commonly known as normal saline,
and 5% (m/v) D-glucose (dextrose) referred to as
D5W (5% dextrose in water).

© 2011 Pearson Education, Inc. Chapter 7 80


7.6 Osmosis and Diffusion, Continued

Diffusion and Dialysis

• Diffusion occurs when there is a net movement


of molecules from the area of high concentration
to the area of low concentration.

© 2011 Pearson Education, Inc. Chapter 7 81


7.6 Osmosis and Diffusion, Continued

• Diffusion is illustrated below.

• Here, a drop of green food coloring is added to a


beaker of water. Over time, the green dye
molecules will diffuse throughout the water, and
the resulting solution will have a uniform green
color.
© 2011 Pearson Education, Inc. Chapter 7 82
7.6 Osmosis and Diffusion, Continued

Kidney Dialysis

• One place where diffusion occurs is in the


kidneys.

• Kidneys act to remove water molecules out of


blood through diffusion across the membranes
in the kidneys.

• Larger molecules, like proteins, are too large to


pass the membrane and get reabsorbed in the
blood.
© 2011 Pearson Education, Inc. Chapter 7 83
7.6 Osmosis and Diffusion, Continued

• Smaller molecules like urea diffuse out of the


blood and move into urine in a process known
as dialysis.

• If the kidneys cannot remove waste products like


urea, increased levels of the waste products
increase in the bloodstream and can become
life-threatening.

• A person whose kidneys have failed can


undergo artificial dialysis called hemodialysis.
© 2011 Pearson Education, Inc. Chapter 7 84
7.6 Osmosis and Diffusion, Continued

• During hemodialysis, blood is removed from the


patient and passes through one side of a
semipermeable membrane in contact on the
opposite side with a dialyzing solution that is
isotonic with normal blood solute concentrations.

• Waste products in the blood will then diffuse out


of the passing blood and into the dialyzing
solution, and the dialyzed blood returns to the
patient.

© 2011 Pearson Education, Inc. Chapter 7 85


7.6 Osmosis and Diffusion, Continued

© 2011 Pearson Education, Inc. Chapter 7 86


7.7 Transport Across Cell Membranes

• How do polar molecules, like glucose, and ions,


like sodium ions, move across cell membranes?

• Recall that the cell membrane’s main structural


components are the phospholipids, which have
a polar head containing a phosphate and a
nonpolar part containing long hydrocarbon tails.

© 2011 Pearson Education, Inc. Chapter 7 87


7.7 Transport Across Cell Membranes,
Continued
The arrangement of the cell membrane is shown
in the following figure.

© 2011 Pearson Education, Inc. Chapter 7 88


7.7 Transport Across Cell Membranes,
Continued
• Ions, nonpolar molecules, and polar molecules
move across cell membranes in different ways.
• There are three forms of transport across
membranes:
1. Passive diffusion is simple diffusion. It does
not require energy. Small molecules and
nonpolar molecules like O2, N2, and CO2 use
this process.
2. Facilitated transport occurs when small
molecules and ions pass through a channel
formed by integral membrane proteins. It
does not require energy.

© 2011 Pearson Education, Inc. Chapter 7 89


7.7 Transport Across Cell Membranes,
Continued

3. Active transport occurs when ions and


small molecules move across the membrane
in the opposite direction of diffusion. They
require the assistance of a protein channel or
pump. Energy expenditure in the form of
adenosine triphosphate (ATP) is required.

© 2011 Pearson Education, Inc. Chapter 7 90


7.7 Transport Across Cell Membranes,
Continued

© 2011 Pearson Education, Inc. Chapter 7 91


Chapter Summary

7.1 Solutions Are Mixtures

• Solutions form when a solute dissolves in


solvent.
• Particles of solutes are evenly distributed.
• A solute and a solvent may be a liquid, a solid,
or a gas.
• Solutions are transparent.
• Mixtures that have particles suspended in a
solution are called colloids. They are not
transparent. Particles will settle upon standing.
© 2011 Pearson Education, Inc. Chapter 7 92
Chapter Summary, Continued
7.2 Formation of Solutions
• Solvation occurs when solute particles are
surrounded by solvent molecules and are
interacting through attractive intermolecular
forces.
• Saturated solutions contain the maximum
amount of solute dissolved in a solvent.
• A saturated solution reaches an equilibrium
where the rate of dissolving and reforming
crystals is the same.
• An increase in temperature increases the
solubility of most solutes in water, but decreases
the solubility of gases in water.
© 2011 Pearson Education, Inc. Chapter 7 93
Chapter Summary, Continued

7.3 Chemical Equations for Solution

• Substances that release ions in solution are


called electrolytes because they conduct
electricity.
• Strong electrolytes completely dissociate in
water.
• Weak electrolytes partially dissociate in water.
• Nonelectrolytes are substances that dissolve in
water, but do not dissociate and do not conduct
an electrical current.
© 2011 Pearson Education, Inc. Chapter 7 94
Chapter Summary, Continued

7.3 Chemical Equations for Solution Formation,


Continued

• The amount of dissolved ion in fluids is


expressed by a unit known as an equivalent.

• The number of equivalents present per mole of


an ion is equal to the charge on that ion.

© 2011 Pearson Education, Inc. Chapter 7 95


Chapter Summary, Continued

7.4 Concentrations
• Concentration is the amount of solute dissolved
in a given amount of solution.
• Fluid replacement solutions are expressed as
mEq/L or in mmole/L.
• Molarity is the number of moles of solute per
liter of solution.
• Other concentrations are: percent mass/volume;
percent mass/mass, and
percent volume/volume. Parts per million and
parts per billion are used to express very dilute
solutions.
© 2011 Pearson Education, Inc. Chapter 7 96
Chapter Summary, Continued

7.5 Dilution

When a solute is diluted, the amount of solute stays


the same, and the volume increases. As a result,
the concentration of the solute decreases.

© 2011 Pearson Education, Inc. Chapter 7 97


Chapter Summary, Continued

7.6 Osmosis and Diffusion

• During osmosis, water passes through a


semipermeable membrane from a solution of
lower concentration to a solution of higher solute
concentration.
• The osmotic pressure exerted on the membrane
is directly related to the number of water
molecules pushing against the membrane.
• Isotonic solutions have osmotic pressures equal
to those of bodily fluids.
© 2011 Pearson Education, Inc. Chapter 7 98
Chapter Summary, Continued

7.6 Osmosis and Diffusion, Continued

• Cells maintain their volume in an isotonic


solution. They will lyse in a hypotonic solution
and shrink (crenate) in a hypertonic solution.

• During dialysis, water and small molecules pass


through a membrane in a related process called
diffusion. Large particles do not pass through
the membrane.

© 2011 Pearson Education, Inc. Chapter 7 99


Chapter Summary, Continued

7.7 Transport Across Cell Membranes

• A semipermeable membrane separates the


contents of a cell from the external fluids.
• Membranes are composed of a lipid bilayer of
phosholipids. The inside of the bilayer is
nonpolar, while the exterior of the bilayer is
polar.
• Molecules are moved in and out of the cell by
three transport processes known as passive
transport, facilitated transport, and active
transport.
© 2011 Pearson Education, Inc. Chapter 7 100

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