The Team

- NUR ASYRIFAH 12171013

- NW TINO 12171012
- RISKA FERANOVITA R 12171017
What is mefenamic acid?

Mefenamic acid is a n o n -
steroidal anti-inflammatory
drug used to treat pain.
It is typically prescribed for
oral administration.
Mefenamic Acid is a white
to greyish-white, odorless,
microcrystalline powder with
a melting point of 230° to
231°C and water solubility of
0.004% at pH 7.1. The chemical
name is N-2,3-xylylanthranilic
acid. The molecular weight is
241.29.
Its molecular formula is
C15H15N02 and the structural formula of
Mefenamic Acid is :
Mefenamic Acid is a non-steroidal anti-
inflammatory drug (NSAID) that exhibits anti-
inflammatory, analgesic, and antipyretic
activities in animal models. The mechanism
of action of Mefenamic Acid, like that of
other NSAIDs, is not completely understood
but may be related to prostaglandin
inhibition.
Absorption

usually reaches peak plasma levels 2 to 4 hours after

oral administration with a half life of 2 hours.

Distribution

Mefenamic acid and its metabolites are firmly bound to

plasma proteins.
MEFENAMICACID has demonstrated analgesic, anti-
inflammatory and antipyretic properties in human clinical
studies and in classical animal test systems. These
effects may be due to its dual action on prostaglandins. It
inhibits the enzymes of prostaglandin syntheses and also
antagonises the actions of prostaglandin at the receptor
sites. These effects may also be responsible for its
effectiveness in the treatment of primary dysmenorrhoea.
Mefenamic acid is used for:

Treatment of primary dysmenorrhoea

Inflammation and fever
soft tissue and dental pain.

Mefenamic acid is an NSAID, NSAIDs treat the symptoms

of pain and inflammation. They do not treat the disease that
causes those symptoms.
 Dental pain or soft tissue
500 mg three times daily

 Children
250 mg three times daily
Not recommended for children under 14 years of age.

Food(before/after)
Should be taken with food.
Symptoms

Symptoms of over dosage are related to the amount of

drug ingested and range from gastrointestinal
discomfort and diarrhea to seizures, acute renal failure,
vertigo, hallucination, coma and death. Plasma levels
of up to 210 μg/mL (therapeutic range 1 to 10 μg/mL)
have been reported resulting in repeated generalised
convulsions, but are not generally useful for evaluation
and management of over dosage.
All medicines may cause side effects, but many
people have no, or minor, side effects.

Constipation, diarrhea, dizziness, gas,

Headache, heartburn, nausea, stomach upset.

Severe allergic reactions

Rash, Hives, Itching, trouble breathing,
tightness in the chest, swelling of the
mouth, face, lips, or tongue.
1. Patients showing evidence of chronic inflammation
and/or active ulceration of either the upper or lower
gastrointestinal tract and patients with pre-existing renal
disease.
2. Patients in whom aspirin and/or other NSAIDs have
induced symptoms of bronchospasm, allergic rhinitis
because the potential exists for cross-sensitivity.

3. Patients with impaired renal function or hepatic failure.

4. Patients previously experiencing diarrhea on taking
this drug.

5. Patients who have previously exhibited

hypersensitivity to mefenamic acid .

6. Patients with severe heart failure.