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INTRODUCTION
T = time
S = stimulus in the vagus
D = contractions of heart D
R = contractions of heart R
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What then are Neurotransmitters?
u Tiny liquid
u Synthesized by the neuron from materials in
the blood
u Chemical messengers across the synapse
u Bind themselves to receptors across the
synapse
u Inhibitory or excitatory
u The influence behaviour
Discovery of each Neurotransmitters
u Acetylcholine ± 1930¶s
u Adrenaline ± 1940¶s
(Noradrenaline a derivative)
u Serotonin - 1940¶s
u Dopamine ± 1950¶s
u Substance P ± late 1950¶s
u Four amino acids discovered in 1960 ±
Glutamate, Aspartate (as excitatory agent), GABA
and Glycine (as inhibitory agents)
u Neuropeptides -1970¶s
After these a lot more have been discovered and are still been
discovered.
Biosynthesis, packaging, and release of neurotransmitters
A quick review of synaptic action
Mesocorticolimbic system
and schizophrenia
Serotonin synthesis
Serotonin
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§cetylcholine (§ch) *Neuromuscular junction *Movement
*Preganglionic autonomic *§utonomic function
synapses *Learning and memory
*Postganglionic
parasympathetic synapses
*Basal forebrain projections
to hippocampus and
amygdala.
Dopamine *Õubstantia nigra and basal *Movement
ganglia *Reinforcement
*Ventral tegmentum *Planning
projections to hippocampus
and amygdala, and nucleus
accumbens
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