Multiple Alleles

Objectives
• Explain the multiple alleles
• Illustrate by means of Punnett square a cross involving multiple alleles
• Give examples showing multiple alleles
Blood Type Inheritance Rules:
1. A person with the IA allele will Cells Genotypes Blood types
have A carbohydrates.
A A A Type A
2. A person with the IB allele will I I ,I i blood
have B carbohydrates.
B B B Type B
3. A person with the recessive i
allele will have no carbohydrates.
I I ,I i blood
4. Or a person with both IA and IB Type AB
alleles will have both A and B IAIB blood
carbohydrates on their cells.
Type O
ii blood
Multiple Alleles: Blood Types (A, B, AB, O)
A and B are co-dominant (Both show)
IAIA = type A
IBIB = type B
IAIB = type AB

A and B are both dominant over O (Regular

dominant/reccessive)
IAi = type A
IBi = type B
ii = type O
 Allele Can Can
(antigen) Donate Receive
Possible on RBC Blood Blood
Phenotype Genotype(s) surface To From
IAIA
A IAi A A, AB A, O
IBIB
B IBi B B, AB B, O
AB A, B,
Universal
AB IAIB Recipient AB AB, O
O A, B,
O ii Universal Donor AB, O O
 Multiple alleles Example
If a woman with AB blood has children with a man who
Cells Genotypes Blood types
has type O, what will be the possible genotypes of their
A A A Type A
I I ,I i blood
children? What will be their blood types?

B B B Type B • Phenotype:
I I ,I i blood 50 % Blood Type A
I A I B 50 % Blood Type B
Type AB
IAIB blood
i IA i IB i • Genotype:
Type O
ii blood i IA i IB i 50 % IA i
50 % IB i
Multiple Alleles- Blood Type
• Phenotype:
50 % Blood Type A
25% Blood Type AB
25 % Blood Type B

• Genotype:
50 % IAIA, IAi
25% IAIB
25 % IBi
• Phenotype:
25% Blood Type AB
25 % Blood Type A
25% Blood Type B
25 % Blood Type O

• Genotype:
25% IAIB
25 % IAi
25% IBi
25 % ii
 Multiple Alleles: Rabbit Fur Colors
Coat color in rabbits is determined by a single allele pair that has at least four
different alleles.
 full color (C), chinchilla (cch), Himalayan (ch), albino (c)
References:
• Department of Education Republic of the Philippines (2014). Science 9 Learners
Module. Pasig City, Philippines: FEP Printing Corporation.

• Department of Education Republic of the Philippines (2016, August). K to 12

Curriculum Guide (Grade 3 to Grade 10). Retrieved from
https://www.deped.gov.ph/wp-content/uploads/2019/01/Science-CG_with-
tagged-sci-equipment_revised.pdf

• Sparks, P. (2015). Heredity. Retrieved from https://slideplayer.com/slide/4690562/