Академический Документы
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Glymphatic System
12
Astrocytes
• Ions & NT regulation in ECF
• Buffering K+
• Beta amyloid protein removal
• Trophic support of neurons, nourish
• Boundaries between adjacent
process(insulate)
• Capillaries & neurons
• Forming glial scar
• Removing debris
• Neurotaxism
• CSF flow
13
• If the cellular system became overloaded or
slowed down as we aged, metabolic garbage
would build up between the cells
• This garbage includes products such as beta-
amyloid, the protein associated with
Alzheimer's disease
14
The meninges: three membranes
envelop the entire CNS
(central nervous system)
dura mater The outer, hardest, toughest
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Maninges
• Dura mater
– Attachments: occip. Sagital, frontal, Crista Galli of
ethmoid, sella tursica of sphenoid, C2-3, S2-3
• Arachnoid
• Subarachnoid
• Pia mater
Spaces between the meninges
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Meninges
• Dura mater
– Outer layer
• Fibrous connective tissue, covering inner aspect of
cranial bones, extend to sutures and outer surface
– Innermost layer
• Falx cerebri
• Tentorium cerebelli
– Sinuses between them
• Arachnoid
• Pia mater
Dura Matter & Dural Sinuses
Reciprocal Tension Membrane(RTM)
• Dural membranes are under constant tension
• Movement of brain & CSF transmit to
membranes as a dynamic shifting of the
reciprocal tension
CSF
• Clear body fluid, produced by plexus choroid
• Nearly protein-free fluid
• Daily production: 500-600 ml
• Total: 100- 160 ml
• https://www.youtube.com/watch?v=JCf273U0ktc
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Cerebrospinal fluid
• Cerebrospinal fluid: watery liquid
is found inside the brain, spinal cord, and
subarachnoid space
supports the brain’s weight
protects and cushions the brain and the spinal
cord
27
CSF
28
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CSF vs Plasma
Substance CSF Plasma
Water Content (%) 99 93
Protein (mg/dL) 35 7000
Glucose (mg/dL) 60 90
Osmolarity (mOsm/L) 295 295
Sodium (mEq/L) 138 138
Potassium (mEq/L) 2.8 4.5
Calcium (mEq/L) 2.1 4.8
Magnesium (mEq/L) 0.3 1.7
Chloride (mEq/L) 119 102
pH 7.33 7.41
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Increased intracranial pressure
• Behavior changes
• Decreased consciousness
• Headache
• Lethargy
• Neurological symptoms, including weakness,
numbness, eye movement problems, and double
vision
• Seizures
• Vomiting
• https://www.youtube.com/watch?v=kaOphkMv2pM
31
CSF
• Choroid plexus
• Ventricles I-IV
• Foramen of Magendie
https://www.youtube.com/watch?v=Gqw4vd8qApQ
Ventricles
CSF & BBB
Flow of CSF
CSF
• CSF; production: 650ml/day- total vol:
125ml/ circulation/composition: isosmotic;
low protein & glucose, hi Na & Cl,
• O2 consumption at rest: 49 ml/min (20% of
total)
• Blood flow at rest: 798 ml/min (15% of total)
https://www.youtube.com/watch?v=FrpVzSK23Q0
Temporal Bone
• Mastoid part
• Squamous part
• Tympanic part
• Zygomatic part
• Styloid process ( anchor for muscles and ligaments)
– stylohyoid ligament
– stylomandibular ligament
– styloglossus muscle
– stylohyoid muscle
– stylopharyngeus muscle
Temporal bone
• The temporal bone articulates with five skull
bones:
• Occiput
• Parietals
• Sphenoid
• Zygomas
• Mandible
Pterion
Pterion
• the region where the frontal, parietal, temporal, and
sphenoid bones join together
• The pterion is known as the weakest part of the skull
• The anterior division of the Middle Meningeal Artery
runs underneath the pterion
• Consequently, a traumatic blow to the pterion may
rupture the middle meningeal artery causing an
epidural hematoma
• The pterion may also be fractured indirectly by blows
to the top or back of the head that place sufficient
force on the skull to fracture the pterion
Bevel angle
• Perpendicular
– Frontal-parietal
• Flat
– Temporal-parietal
Sutherland model
• By Garner Sutherland
– Movement of cranial sutures, ---> craniosacral
concept
– Cranial Rhythmic Impulse(CRI)
• Is the motility* of the nervous system
73
Receptive field
74
Stimulus Receptor Location Receptive Adaptation
field
mechanoreception
Touch, pressure Free nerve ending Hair root Variable
Small
Texture, steady Merkel receptor Slow
pressure Superficial
Flutter, stroking Meissner Rapid
Stretch Ruffini Deep Large Slow
Vibration Pacinian corpuscle Extremely rapid
Thermoreception
Cold Free nerve ending Superficial Small Rapid
Warm
Nociception
Thermal Small Rapid
Free nerve ending Superficial
Mechanical Large Slow
Polymodal ( chemical) Large Slow
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Theory
• Balancing CSF circulation and pressure by way
of releasing the reciprocal tension membrane
of the Meningeal System or the Dural tube
• Cranial Sacral Therapy utilizes the cranial
bones and the sacrum as levers on the Dural
tube in a manner that through traction 'folds'
or ‘rifts’ on the meningeal membrane are
stretched and re-aligned
Dural attachments
Reciprocal Tension Membranes
Flexion and Extension
• Flexion is the normal motility movement
– Induces a swelling sensation
• Extension
SBS
Flexion
• Fluctuation of CSF
• Articular mobility of the cranial bones
• Involuntary motion of sacrum
• Inherent mobility of brain & Sp.cord
Flexion/Extension
Flexion & Extension
Cranial Flexion
Malposition
• A sacral malposition affects the
Occipitoatlantoaxial (OAA) complex just as
much as a malposition in the temporal bone
or sphenoidal bone
• The consequences are even greater in the
spinal column because the sensitive muscle
spindles there have an exponential effect
Venous Sinuses
• 1/3rd of blood in brain