• Nowadays, the emerging cyber physical system (CPS) presents a significant opportunity to implement smart manufacturing. • the realization of the increasing importance of integration between computing systems and physical processes gave rise to CPS. • The CPS can assist manufacturing systems with advanced technologies, including Internet of Things (IoT) , big data analytics , cloud computing etc. • Overview of CPS-PMH This research focuses mainly on discrete manufacturing shop-floors which have a centralized storage area and limited buffer around each workstation. The objective of the proposed method is to change traditional passive material handling strategy by using predictive analytics and CPS technologies. Proactive material handling • Proactive material handling is responsible for making material handling decisions based on the prediction of the future status of manufacturing systems, including future logistics tasks prediction and trolley status prediction. In a shop-floor, mainly four kinds of logistics tasks are important, i.e., raw material entrance (from warehouse or last shop-floor to the shop-floor), processed WIPs movement (from one workstation to next workstation or CSA), queuing WIP movement (from CSA to workstation), and finished product exit (to outside warehouse or next shop-floor). This paper focuses on the WIP movement within a shop-floor, i.e., the second and third kind tasks. Problem Here, an industrial case from a collaborative company is used to demonstrate the proposed CPS-PMH. The company is a typical manufacturer for tire mould production in Southern China. Since the sizes of most tire moulds are large, it is expensive to keep a buffer area for each machine. The shop-floor sets a CSA to store the materials and no buffer is set around each machine. As a result, the WIPs need to be moved to the CSA or next workstation directly from the manufacturing machine; otherwise, the machine will be occupied and cannot process following materials. Currently, the shop-floor uses a passive and manual material handling strategy in its logistics system: 1) after a WIP is processed, the manufacturing worker asks an idle logistics worker to move the WIP and bring next WIP. 2) the logistics worker finds a trolley and takes related tools to load the WIP. 3) the logistics worker moves the WIP according to his experience and production plan. 4) the logistics worker finds next WIP and bring it to the machine. Under this situation, a long idle time of the machine is often consumed and much unnecessary energy consumption from both trolleys and machines is also wasted. Therefore, the company is truly in need of CPS-PMH methods and tools. Proactive material handling method • After the RPT of all the current WIPs in the shop-floor is forecasted, the proactive material handling method can be involved. Firstly, a set of logistics tasks are created based on the RPT prediction information. Secondly, a limited number of tasks are extracted, for example, a set of top 20 logistics tasks are selected in Table 2. It can be seen that the selected tasks consist of four important attributes, i.e., release time from last machine, use time of next machine, from and to location of predicted tasks, occupation energy consumption, and idle energy consumption. Then, the smart trolleys that will be available before the last task releases are filtered, as shown in Table 3. Two main kinds of information are given, i.e., available time and available location. Conclusion • In order to cope with frequent changes and disturbances, many companies applying advanced CPS technologies to keep high-level production traceability and controllability about its shop- floor. • The main contributions of this work include an overall architecture of a proactive material handling method for CPS-enabled shop-floor. a proactive material handling strategy which can consider both realtime and future status of smart trolleys and WIPs at the same time. The proposed CPS-PMH and its key technologies provide an opportunity to improve shop-floor production fluency and efficiency. challenge is how to incorporate the proposed CPS-PMH with other enterprise information systems (EISs) (such as advanced planning system, MRP, etc.) so that more feasible and optimal production and logistics schedule can be made. The third challenge is how to combine the more comprehensive big data.