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Exocrine glands
• Secrete products into ducts
• E.g. sudoriferous glands, sebaceous glands
Endocrine glands
• Secrete products directly into the interstitial fluid
• E.g. pituitary, thyroid, parathyroid, adrenal and pineal glands
THE ENDOCRINE SYSTEM
Organs that contain hormone-
secreting cells:
• Hypothalamus
• Liver
• Thymus • Small intestine
• Pancreas • Skin
• Ovaries
• Heart
• Testes
• Adipose tissue
• Kidneys
• Placenta
• Stomach
FUNCTION OF HORMONES
• Regulate chemical composition and volume of extracellular fluid
• Regulate metabolism and energy balance
• Regulate contraction of smooth and cardiac muscle fibers
• Regulate glandular secretion and other immune system activities
• Control growth and development
• Regulate operation of reproductive systems
• Help establish circadian rhythms
HORMONE RECEPTORS
Up-regulation
• Makes a cell more sensitive to a hormone
• Occurs when there’s a deficient amount of hormone
CIRCULATING AND LOCAL HORMONES
Circulating hormones
• Pass from secretory cells that
make them into interstitial
fluid and then into the blood
• May linger in the circulation
CIRCULATING AND LOCAL HORMONES
Local hormones
• Act locally on neighbouring
cells or on the same cell that
secreted them without
entering the bloodstream
• Inactivated quickly
• Paracrine
• Act on neighbouring cells
• Autocrine
• Act on the same cell that
secreted them
CHEMICAL CLASSES OF HORMONES
LIPID-SOLUBLE HORMONES
• Hormones are able to diffuse
through the plasma
membrane.
• Receptors are located within
the target cell, hence binding
happens inside the cell.
MECHANISM OF HORMONE ACTION
WATER-SOLUBLE HORMONES
• Hormones cannot diffuse
through the plasma
membrane.
• Receptors are located on the
surface of the cell and exist
as integral transmembrane
proteins in the plasma
membrane.
HORMONE INTERACTIONS
The responsiveness of a target cell to a hormone
depends on the following:
1. Hormone concentration in the blood
2. Abundance of target cell’s hormone receptors
3. Influences exerted by other hormones
HORMONE INTERACTIONS
PERMISSIVE EFFECT
• Actions of some hormones on target cells require a simultaneous or recent
exposure to a second hormone.
• E.g. EPINEPHRINE weakly stimulates lipolysis. Together with THYROID
HORMONES, they stimulate lipolysis more powerfully.
SYNERGISTIC EFFECT
• The effect of two hormones acting together is greater than the sum of their
individual effects.
• E.g. GLUCAGON & EPINEPHRINE both increase blood glucose concentration
ANTAGONISTIC EFFECT
• One hormone opposes the action of another hormone.
• E.g. INSULIN promotes glycogen synthesis; GLUCAGON promotes glycogen
breakdown.
HORMONE SECRETION
Hormone secretion is regulated by the following:
1. Signals from the nervous system
2. Chemical changes in the blood
3. Other hormones
PARS TUBERALIS
• Arises from the thickened lateral walls of the pouch
• Forms a collar or sheath around the infundibulum
POSTERIOR PITUITARY GLAND
PARS NERVOSA
• The larger bulbar portion of the posterior pituitary gland
• Contains neurosecretory axons and their endings
INFUNDIBULUM
• Continuous with the median eminence
• Contains neurosecretory axons forming the
hypothalamohypophyseal tracts
ANTERIOR PITUITARY GLAND
ANTERIOR PITUITARY GLAND
1. Somatotrophs
• Secrete GH
2. Thyrotrophs
• Secrete TSH
3. Gonadotrophs
• Secrete FSH & LH
4. Lactotrophs
• Secrete PRL
5. Corticotrophs
• Secrete ACTH; also
MELANOCYTE-STIMULATING
HORMONE (MSH)
ANTERIOR PITUITARY GLAND
Secretes two inhibiting hormones:
• Growth hormone-inhibiting hormone
• Somatostatin
• Suppresses secretion of GH
• Prolactin-inhibiting hormone
• Dopamine
• Suppresses secretion of PRL
ANTERIOR PITUITARY GLAND
TARGET GH ANT.
CELLS SECRETION PITUITARY
OVARIES, LH ANT.
TESTES SECRETION PITUITARY
MILK
PRODUCTION PROLACTIN ANT.
in MAMMARY SECRETION PITUITARY
GLAND
*PROLACTIN-RELEASING HORMONE
Suppressed by DOPAMINE secreted by the HYPOTHALAMUS
PROLACTIN
Premenstrual period
• High dopamine levels, low prolactin levels
During pregnancy
• High prolactin levels
PROLACTIN
Destruction of hypothalamus
• = prolactin excess
• I.e. galactorrhea, amenorrhea
• Due to loss of inhibitory control of dopamine
• May be treated with bromocriptine (dopamine agonist)
CORTISOL,
If excessive GLUCOCORTICOIDS NEGATIVE FEEDBACK
GLUCO-
*CORTICOTROPIN-RELEASING HORMONE
CORTICOIDS
THERE IS NO GONADOTROPIN-INHIBITING HORMONE.
POSTERIOR PITUITARY GLAND
POSTERIOR PITUITARY
• Does not synthesize hormones; the HYPOTHALAMUS does
• Paraventricular nuclei
• Synthesizes oxytocin
• Supraoptic nuclei
• Synthesizes antidiuretic hormone
HORMONES
SYNTHESIS in
HYPOTHALAMUS
STORED in
HORMONES MOVE via AXON
HYPOTHALAMIC-
STORED in HYPOPHYSEAL
TERMINALS in
VESICLES TRACT POST.
PITUITARY
• Stimuli:
• Suckling of infant
• Cervical dilation, orgasm
• Actions:
• Contraction of uterus
• Contraction of myoepithelial cells in the breast milk ejection
STIMULUS
RVICA
RELEASE OF
EXOCYTOSIS
HYPOTHALAMUS OXYTOCIN TO
of VESICLES BLOODSTREAM
UTERUS,
BREAST
ANTIDIURETIC HORMONE
Actions:
• Increase water permeability
• Constriction of vascular smooth muscles
EXOCYTOSIS
OSMO-
INC SERUM of VESICLES
RECEPTORS in
OSMOLARITY HYPOTHALAMUS CONTAINING
ADH
KIDNEYS KIDNEY,
RETAIN WATER; SMOOTH RELEASE OF
SMOOTH MUSCLES in ADH TO
MUSCLES BLOOD BLOODSTREAM
CONSTRICT VESSELS