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TOXICOLOGY
1. Cultural Hazard
2. Chemical Hazard
3. Physical Hazard HARM
4. Biological Hazard
Depends on:
Dose
Frequency of exposure
Age and size
Detoxification System
Genetic Makeup
Risk: Exposure*Vulnerability*Hazard
QUIZ 1
Kahoot
CONCEPTS
Scope
Consequences in
life
Classification by Scope
Systemic Toxicants
Organ Toxicants or
Tissues Toxicant
(Neurotoxicants,)
https://toxtutor.nlm.nih.gov/01-002.html
Classification by its consequences
Carcinogens
Mutagens
Teratogens
Allergens
Neurotoxins
Endocrine disruptors
DOSE
Amount of a substance administered at one time.
However, other parameters are needed to describe
the exposure to any substante; such as: number of
doses, frequency and total time period of the
treatment.
Environmental toxicology uses
concentration units to represent
a dose
DOSE
Lethal Dose 50 (LD50)
To describe toxic effect, toxicologists use the
symbol LD50, which is “A statistically derived dose
at which 50% of the individuals will be expected to
die”
Used to compare the toxicities of different
chemicals
Harmful effect in an organism
Acute through a single or short term
exposure
Types of
Toxicity Ability of a substance or a
mixture of subsances to
cause harmful effects over
an extended period,
Chronic usually upon repeated or
continuous exposure,
sometimes lasting for the
entire life of the exposed
organism
Toxic Response
Def. Reaction to a toxicant
Classificated by:
Location