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By James Kateregga
1 11/25/20
Sex and Gender
4 11/25/20
Masculine, Feminine
or Androgynous?
Prior to week 7
Differentiation in
progress
Fully differentiated
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Becoming anatomically “normal”
Normally, the Y chromosome initiates changes in the
embryo that begin the production of testosterone,
which will masculinize the embryo. Without
testosterone, the male pathway cannot develop and
the organs will feminize.
Male development – gonads > testes; Wolffian ducts
> internal male reproductive structures.
Female development – gonads > ovaries; Mullerian
ducts > internal female reproductive structures.
External genitalia take on the male form in the
presence of testosterone; without it, the female.
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Sexual differentiation of the brain
Sex differences in the brain are small but
significant in a few ways. Testosterone appears
to play a role.
Gender identity, sexual orientation and some
sexual behaviors are governed by small areas of
the hypothalamus.
Both animal and human studies continue to shed
light on other sex differences in behavior and
cognition.
In general, we are more the same than different.
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Variations:
Intersexed individuals
Prenatal irregularities in either chromosomes
or hormones can lead to development of
ambiguous genitalia. These individuals are
called “intersexuals.”
In the not-so-distant past, doctors were quick
to assign a sex based upon what the genitals
looked most like or availability of surgery to
create more female-looking genitals, but the
idea that gender identity may be set in the
brain prenatally was not considered.
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A failed experiment
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Other chromosome variations
Turner’s syndrome – X0
– 1 in 2,000-3,000 live births
– Ovaries never develop properly > absence of
ovarian hormones.
– They do not menstruate or develop adult breasts
and are usually infertile.
– Usually short, and with skeletal abnormalities.
Stella Walsh – some body cells were XX and
some were XY. She lived as a woman but had
nonfunctional male organs. World class athlete.
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Hormonal variations
Hermaphroditism – having both male and
female reproductive systems due to failure of
primitive gonads to differentiate.
– 1 in 65,000 births; usually genetic females
– Often have one ovary and Fallopian tube on one
side and one vas deferens and a teste on the
other, usually with a uterus in between
– Ambiguous external genitalia
– 2/3 are raised as boys but at puberty develop
breasts and begin to menstruate
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Other hormonal variations
Pseudohermaphroditism – having either testes
or ovaries (matching the genetic sex) but with
either ambiguous genitalia or genitalia of the
other sex.
– Many have early problems with gender identity but
most have a heterosexual orientation as adults.
– Hormonal and surgical treatments partially correct
the appearance of the genitals.
– Adrenogenital syndrome – 1 in 20,000 births;
An XX embryo’s adrenal glands secrete too much
masculinizing hormone > masculine genitalia.
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Pseudohermaphroditism, cont’d.
– Androgen insensitivity syndrome (AGS) – 1 in
20,000 births; XY testes secrete testosterone but embryonic
tissues fail to respond.
– Female internal structures do not develop because the
Mullerian duct inhibiting substance is correctly “read” by the
embryo.
– External genitals generally appear very feminine. Testes do
not descend.
– DHT Deficiency type AGS – 38 boys in the Dominican
Republic; 18 raised as girls until puberty and then adopted
a male identity; this culture could accept a change from
female to male and called them quevote (“penis at twelve”)
boys.
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Gender and sex
as social constructs
In our culture in Uganda and world over, we are
committed to the idea of persons being either male
or female; we accept no third sex, anatomically or
socially.
Gender is a social construction of femininity and
masculinity; differences in temperament and
behavior we expect beyond anatomical differences.
Awareness of intersexed individuals helps us see
that sex is not dichotomous
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Gender Identity “Disorder” (GID)
Gender dysphoria – when gender identity does
not match anatomical sex; the person feels
trapped inside the wrong body.
– Awareness often occurs in childhood, with boys
outnumbering girls 7:1 prior to adolescence.
– Adults with this condition are referred to as
transsexuals
– Male-to-female transsexuals outnumber female-to-
male transsexuals 2:1.
– Most are heterosexual in relationship to their gender
identity.
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Transsexualism
Differs from transvestism (cross-dressing for
sexual arousal); GID is a gender identity issue.
Causes are not well understood but male-to-
female transsexuals have a hypothalamus more
similar to a female’s than to a male’s.
Parent-child interactions may also play a role.
Sex reassignment surgery follows a long period
of psychotherapy and living as the other sex.
Psychotherapy alone does not “cure” GID.
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Transgenderism: Living as the
Other Sex