Writing Problem and Hypothesis

Statements for Medical Research(7)

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Setting of work proposal :
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Work problem :
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Quantitative specification of problem :

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Importance of problem :
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Project need : ,
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Work objective : ?
Methodology to achieve objective
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Anticipated results :
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Contribution to field :
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()
Patients with cutaneous lymphoma have lesions around their
total skin area, making treatment with surgical operation impossible and
chemotherapy or radiation therapy as the only viable options. Radiation
therapy can alleviate the condition of skin scratches. The most effective
radiation therapy is the Standford of six dual fields. However, this
treatment requires a relatively long distance away from the patient in the
treatment room so that the patients body can be covered. (NOTE : Add 2-4
sentences that describe characteristics of the problem or statistics that reflect
its severity) Consequently, the source-to-surface distance
must be set to 415cm, i.e. longer than other hospital department uses, with
electron beams having an energy range of 4 to 9 MeV. A hospital without a
large treatment room would find such treatment impossible to perform.
For clinical considerations, this must be spread around to the dose
distribution and decrease the SSD to less than 300cm.
Therefore, the feasibility of adopting total skin electron beam irradiation (TESI)
must be examined to treat patients with pruritus skin cancer by attempting to
improve the dose distribution and decrease the SSD to less than 300 cm
through variation of the dosage level, as achieved by electron energy, the
scattering material, proximity of patient to the electron beam and variation in
treatment angle.
()
The feasibility of adopting total skin electron beam irradiation
(TESI) can be examined to treat patients with pruritus skin cancer by
attempting to improve the dose distribution and decrease the SSD to
less than 300 cm through variation of the dosage level, as achieved by
electron energy, the scattering material, proximity of patient to the
electron beam and variation in treatment angle. To
do so, uniform dose distribution and reduced photon dose for patients
can be achieved under the following conditions: a range of 4 MeV 12
MeV of electron energy, a distance of 3 5 meters between the patient
receiving treatment and the electron beam, and a range of 15 20
degrees in treatment angle. The scattering material can comprise
acrylic, wire netting and plastic material. Finally, the dose distribution
can be measured under various conditions. As anticipated,
analytical results can demonstrate the effectiveness of adopting TESI
to treat patients with pruritus skin cancer. The results of
this study can provide a valuable reference when treating patients with
pruritus skin cancer. (NOTE : Add 2-4 sentences that describe more
thoroughly how the proposed method contributes to a particular field or
sector)
()
Industrial Technology Research Institute (ITRI) of Taiwan has
been exploring the feasibility of using natural radioactive material in clothing to
preserve warmth and comfort, with tentative plans to manufacture such clothing
with radioactivity material in the near future. However, neither a
comprehensive verification system nor standards have been established for
this method owing to its novel technological application, possibly leading to
damage to the human body from the radiation spontaneously irradiated by
natural radioactivity nuclei despite the original intention of producing warmth.
(NOTE : Add 2 sentences that describe characteristics of the problem or
statistics that reflect its severity) Owing to their varying
characteristics, cells have different radiation dose acceptance levels. For
instance, while some cells, e.g., completed division cells, can receive a
radiation dose of 20Gy to induce certain biological effects, others, e.g.,
uncompleted division cells, can not receive a radiation dose exceeding 5Gy.
The inability to ensure that humans would not incur radiation
harm from such an application in clothing manufacturing would neglect the
potential of adopting natural radioactive material to sustain body warmth and
comfort in apparel wear. Therefore, a comprehensive
verification system must be devised for a novel radiation dose-based method
already developed at Industrial Technology Research Institute (ITRI) to
enhance the warmth and comfort of clothing through radiation irradiated by
natural radioactive materials.
()
A comprehensive verification system can be devised for a novel
radiation dose-based method already developed at Industrial Technology
Research Institute (ITRI) to enhance the warmth and comfort of clothing
through radiation irradiated by natural radioactive materials.
To do so, the radiation dose in clothing containing natural radioactive materials
can be measured. The radiation dose in the clothing can then be calculated
and simulated using Monte Carlo software. Next, a correlation of the results
can be made using the two steps of radiation dose calculation. By using Monte
Carlo software, both the actual radiation dose measurements and the validity of
the actual human measurements can be verified. After the validity of actual
measurements is confirmed, the steps of dose measurement can be
constructed. The entire verification standard can be established as well.
As anticipated, according to the proposed verification system the
average human radiation dose adopted from nature and article radiation can be
1.62 mSv/y. Under 5 cGy, although the radiation dose does not have any the
biological effect, it causes a slight blood change when the radiation dose
exceeds 15 cGy. Therefore, adequate control should be made of the radiation
dose irradiated from the clothing containing radioactive material; safety must
also be ensured when warming the clothing. Results of this study
can contribute to ongoing efforts to establish a radiation dose measurement
process and standard, thus ensuring safety when warm and comfortable
clothing are worn. (NOTE : Add 2-4 sentences that describe more thoroughly
how the proposed method contributes to a particular field or sector)
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