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R1
Hepatic disease clinical manifestation extensive damage little reserve marginal patient OR further hepatic decompensation overt hepatic failure
HEPATITIS
ACUTE HEPATITIS
viral infection, drug reaction, exposure to hepatotoxin Acute hepatocellular injury with variable amounts of cell necrosis
Viral hepatitis
Transmission
z z z
Hepatitis A & E : oral-fecal route Hepatitis B & C : percutaneously & by contact with body fluids Hepatitis D : host hepatitis B virus 1- to 2-week mild prodromal illness
~
Clinical manifestions
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Jaudice
~ ~
Prognosis
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3-10%, C
0.5-1%
50%
)
HBsAg(+) Pt
0.3-30%, hepatitis C
Immunization
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Highly effective against hepatitis B infection Postexposure prophylaxis with hyperimmune globulin is effective for hepatitis B Hepatitis C vaccine, prophylaxis
Drug-induced hepatitis
Cause
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Direct dose-dependent toxicity of a drug Idiosyncratic drug reaction Chronic alcohol ingestion fatty infiltration hepatomegaly
~ ~
Alcoholic hepatitis
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Impaired fatty acid oxidation Increased uptake & esterification of fatty acid Diminished lipoprotein synthesis & secretion
Acetaminophen ingestion
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fatal
Preoperative considerations
Elective surgery
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acute hepatitis
resolve
LFT normalization Periop. Morbidity(12%), mortality(10% with laparotomy) Acute alcohol toxicity : greatly complicated
~
alcohol withdrawal
Lab. Evaluation
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BUN, s-electrolyte, creatinine, glucose, transaminases, alkaline phosphatase, albumin, PT, platelet count Alcoholic hepatitis ALT AST PT : best indicator of hepatic synthetic function
~
Vit. K
PT 3 sec
z z z z
drug exposure, transfusion, prior enesthetics Dehydration & electrolyte abNL Coagulopathy Vit. K, FFP Premedi
~
Acute withdrawal
alcoholic Pt.
Intraoperative considerations
Goal
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Preserve existing hepatic function Avoid factors that may be detrimental to the liver Cross-tolerance to anesthetics Close cardiovascular monitoring
~
Alcoholic Pt
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Alcohol
IV
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~
inhalation anesthetics
Standard induction doses of IV agents
Metabolism or excretion redistribution
Coagulopathy
~
regional anesthetia
Hypotension
CHRONIC HEPATITIS
Persistent hepatic inflammation for longer than 6 months
z
Liver biopsy
1.
cellular architecture
portal tract
chronic inflammation
2.
Resolve acute hepatitis, but recurrent exacerbations Hepatic lobule inflammation necrosis foci chronic hepatic inflammation LC : 20-50% hepatitic B or C sequelae Fatigue, recurrent jaundice Only a mild elevation in serum aminotransferase activity
z
3.
Chr. hepatitis B or C
Anesthetic management
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Chronic persistent or lobular hepatitis acute hepatitis Chronic active hepatitis cirrhosis
CIRRHOSIS
Cirrhosis
m/c cause in US : alcohol
z
chronic active hepatitis, chronic biliary inflammation or obx., chronic Rt-sided CHF, autoimmune hepatitis, hemochromatosis, Wilsons disease, 1-antitrypsin deficiency, nonalcoholic steatohepatitis, cryptogenic cirrhosis , Signs Symptoms
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Jaundice, ascites Spider angiomas, palmar erythema, gynecomastia, splenomegaly Variceal hemorrhage from portal hypertension Intractable fluid retention in ascites, hepatorenal syndrome Hepatic encephalopathy, coma
3 Major complications
~ ~ ~
10%
HCC
Preoperative considerations
a. gastrointestinal manifestations
Portal-systemic venous collateral channels
z
Gastroesophageal
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nitrogen load
q
z
z z
z z z
Preoperative considerations
b. hematological manifestations
z
Anemia
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Blood loss, RBC destruction , bone barrow suppression, nutritional deficiencies Congestive splenomegaly (from portal HTN) Decreased hepatic synthesis
Thrombocytopenia, leukopenia
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encephalopathy
z
~ ~
platelet
Preoperative considerations
c. circulatory manifestations
Systemic & pulm. circulation Anemia blood viscosity filling pr. systemic vascular resistance cardiac output cirrhotic cardiomyopathy
Preoperative considerations
d. respiratory manifestations
Hyperventilation
z
Primary respiratory alkalosis Rt-to-Lt shunting (up to 40% of cardiac output) Shunt pulm. A-V communications, V-Q mismatching
Hypoxemia
z
Preoperative considerations
e. renal manifestations and fluid balance
Ascites
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Portal HTN hydrostatic pr. intestine peritoneal cavity fluid transudation Hypoalbuminemia plasma oncotic pr. fluid transudation Protein-rich lymphatic fluid serosal surface of liver Renal sodium retention
~
e Underfillingf
Renal perfusion , intrarenal hemodynamics , proximal & distal sodium reabsorption , free water clearance hyponatremia (dilutional), hypokalemia (excessive urinary potassium losses)
Preoperative considerations
e. renal manifestations and fluid balance
Hepatorenal syndrome
z
z z
Progressive oliguria, avid sodium retention, azotemia, intrractable ascites Very high mortality rate Liver transplantation u diuresis Acute intravascular fluid deficit Ascites pph. Edema 1 /d Loop diuretics
~
z z z
Hyponatremia (<120mEq/L) water restriction Potassium deficit Prophylactic periop. Mannitol infusion may be effective in preventing renal failure
Preoperative considerations
f. central nervous system manifestations
Hepatic encephalopathy
z z
z
~
EEG changes
Symmetric high-voltage, slow-wave activity
ICP G-I cleeding Increased dietary protein intake Hypokalemic alkalosis (from vomiting or diuresis) Infections Worsening liver function
aggressive
z
Oral lactulose 30-50mL every 8h or neomycin 500mg every 6h reduce intestinal ammonia absorption Avoidance of sedatives
Intraoperative considerations
Hepatitis B or C carrier : blood & body fluid Drug responses
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Unpredictable for response to anesthetic agents NMBAs highly ionized drug volume of distribution
~
Hepatic elimination
Anesthetic technique
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Hypotension Induction : barbiturate or propofol induction Maintenance : isoflurane in oxygen or oxygen-air mixture Opioid supplementation : half-life prolonged resp. depression Cisatracurium : NMBA of choice (unique nonhepatic metabolism)
General anesthesia
~ ~ ~ ~
z z
Preoxygenation & rapid-sequence induction with cricoid pressure Unstable pt. & active bleeding
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Awake intubation Rapid-sequence induction with cricoid pr., using ketamine (or etomidate) & succinylcholijne
Vasopressin 5-lead ECG ABGA : acid-base status Large Rt-to-Lt intrapulm. Shunt
~ ~
MI
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Intraarterial pr. Monitoring Intravascular volume status : CVP, pulm. a. pr. Monitoring Urinary output intravascular volume & urinary output Colloid iv fluid(albumin)
~ ~
Fluid replacement
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Transfusion
~
z
citrate toxicity
Hypocalcemia
HEPATOBILIARY DISEASE
Hepatobiliary disease
Cholestasis
z z
Progressive jaundice, dark urine with pale stool, pruritus Extrahepatic obx of biliary tract : m/c cause
~
Gallstone, stricture, tumor in common hepatic duct Viral hepatitis, idiosyncratic drug reaction (phenothiazine, oral contraceptives)
Intrahepatic cholestasis
~
Cholelithiasis
z z z z
Cholecystitis : RUQ tenderness, fever, leukocytosis Cholangitis : chill or high fever Acute cholecystitis 75% medical treatment 2-7 5-10% acalculous cholecystitis
~
Nasogastric suction, iv fluids, antibiotics, opioid analgesics critically ill pt. gangrene & perf.
Acalculous cholecystitis
~ ~
vit.K deficiency
FFP
Vit.K
, PT
Intraoperative considerations
z
opioid
naloxone or glucagon
Renal elimination
HEPATIC SURGERY
Common hepatic procedures
z
Repair of lacerations, drainage of abscesses, resections for tumors Multiple large-bore iv catheters Fluid(blood) warmers Arterial pr., CVP monitoring Antifibrinolytics
~
Hepatic surgery
z z z z
Aprotinin,
Postop Cx
z