TRANING PERIOD IN VISA DRUGS & PHARMACEUTICALS BADDI (HP)

Name: Harwinder Kumar Roll No. 81307421017 Address :- V.P.O Khera, pin code 146106,Dist Hoshiarpur. Contacts - 01884242575, +919464065575. Email Id:- harwinderpandit@yahoo.com harwinderpandit@hotmail.com

Collage:- RAYAT BAHRA INSTITUTE OF PHARMACY (Hoshiarpur, PUNJAB) Site:- http://home.rayatbahra.com/

Instruments1. Paste kettle 2. RMG (Rapid Mixer Granulator) 3. FBD (Fluid Bed Dryer) 4. Vibro Sifter 5. Multimill 6. Blenders ( Double Cone Blender & octagonal blender) 7. Tablet Compression Machine 8. Tablet Coating Pan

 Capacity-

50 to 300 ltrs ( 65 ltrs) Set temp- 400 degrees Celsius Act temp (actual temp of liquid present in paste kettle. It
may be varies acc. to time when paste kettle is on and if set temp is 400 degree Celsius then the liquid have to reach at that temp bye the heater then heater stops.)

USE-The paste kettle, is designed for binder paste preparation.

The Rapid Mixer Granulator is mixing unit with a bottom entry agitator ad side mounted chopper for granulation. It is used for dry blending, wet mixing, preparation of dough and granulation, i.e. cutting of the wet mass into small size granules. It works on the basic principle of agitation of the contents of the bowl at moderate speed and then running a specially profiled cutter blade at high speeds into the wet mass.

PRINCIPLE-

Total capacity 250 ltrs Working capacity- 200ltrs Working time 20 to 30mins (for one lot) Speed 100rpm USE- Homogenous mixing of dry & wet powders, deaglomeration of wet mass and
fast dispersion of binding agent.

 PRINCIPLE In FBD , hot air is passed at high pressure through a perforated bottom of the container containing granules to be dried. The granules are lifted from the bottom and suspended in the stream of air . This condition is called fluidized state . The air is surrounding every granules to completely dry them. Capacity-

60kg & 120kg Working time 20 to 40mins USES- FBD is popularly used for drying of
granules in the production of tablets. It can also used for three operations such as mixing , granulations, and drying. It is modified for coating of granules.

PRINCIPLE- Vibro Sifter consists of Specially Designed Motor mounted vertically

at the center of the base plate of the Screen. The Screen is in between feeding hopper and bowl. The material is fed on to the centre of top screen. The undersize material passes rapidly through the screen during its travel to the periphery. The over size material get continuously discharged through a tangential outlet.

Mesh size - 4 to 300 Mesh(acc. to granules) Capacity - 50 Kg/Hr to 300 Kg/Hr USES- Vibro Sifter is a versatile screening, sieving, grading for separation of solid
from solid and liquid from solid.

Mesh size 2, 4, 6, 8, 10, 12, 14, 16, 20, 24, 30, 40, 50. Rotor RPM : 750 / 1400 / 2200 / 2800 Out Put : 50 kg to 200 kg/hour(depending upon
the product and the reduction required In size.)

Beaters : 12 nos. with knife and impact edges.and

2 scraper blades
USES- ulti Mill is widely used for wet and dry granulation, pulverisation etc., in Pharmaceuticals, Chemicals, Cosmetics, Ceramics, Colours, Dyestuff, Food products etc. It also finds application in Pesticides, Fertilizers, Spices, Detergents, Insecticides, Plastics and Resins Industries.

 1.

DOUBLE CONE BLENDER

Volume capacity 320ltrs Working capacity 100kg Speed 9-10rpm USES- The Double Cone Blender is efficient and versatile equipment for homogeneous mixing of dry powder and granules. This is also used for lubrication.

 Volume

capacity 650ltrs Working capacity 500kg Speed 10rpm USES - Octagonal Blender is widely used for blending, mixing
and homogenizing in Pharmaceuticals, Chemicals, Cosmetics, Ceramics, Colours, Dyestuff, Food products etc

Hopper for holding and feeding granulation to be compressed. Dies that define the size and shape of the tablet. Punches for compressing the granulation within the dies. Cam tracks for guiding the movement of the punches. Feeding mechanisms for moving granulation from the hopper into the dies. Maximum speed- 100rpm Working speed- 26rpm

 Capacity

60-100kg Blower temp. 40to 80C (controlled by thermostat) Spray rate 100ml/min (coating material) Working time- 2-3hrs(for one lot) Speed of pan- 10rpm USES- Coating pans are used to form an aqueous or organic
film around any kind of pellets and tablets or micro granules. These pans are also widely used to sugar-coat tablets

 Beta

Lactum Tablets Con pod 200mg (Cefpodoxine proxetil) Cefnat-o-50-DT(Cefexine)

Non

Beta Lactum Tablets Ulticept 500 (ciprofloxacin 500mg) Diazacid- MPS (antacid) Dexacona Embenor 400 (Norfloxacin)

Harwinder kumar

 CONDITIONS

FOR BETA LACTUM POWDER

FILLING Temperature 23to 27C Humidity - below 23% CONDITIONS FOR NON BETA LACTUM POWDER FILLING Temperature 23to 27C Humidity - 45 to 55%

The functions of first station include capsule feeding, aligning and insertion into bores of holding ring . Also, vacuum is used for separating capsule cap and body in first station. After orientation of capsule, capsule cap can stay in upper holding ring and capsule body can stay in lower holding ring.

Separate the holding ring,put the lower (body) holding ring on the rotary table, pull the powder hopper over the lower (body) holding ring, then auger inside powder hopper starts to run and fill powder into the capsule body. While Iower holding ring turns one circle, push powder hopper to its original position.

Put upper holding ring and lower holding ring together, then take the holding ring ahead of ejector and aim ejector at the bores of holding ring . Use hydraulic cylinder to push ejector and let it press capsules for closing. Finally push capsules inside the bores of holding ring out, the finished capsules will be collected into the container.

 Polishing

machine is used after capsules are filled for cleaning the powder attached on the capsules surface.
APPLICABILITY: Applicable to all size of capsules (#)
000, 00, 0, 1, 2, 3, 4, 5.

 Beta

Lactum Capsules Cepmox 250 (Amoxycillin) Natcocillin 250 (Ampicillin) Non Beta Lactum Capsules Panta con DSR ( Pantaprozole & domparidone) Tetralin 250 (Tetracycline hydrochloride) Omec 20 (Omeprazole)

 In

this packing one side of tablet stripes is PVC (Poly vinyl Chloride) and another side is alumininum foil is used. 1.PVC FOILS- 1. PVC (Poly vinyl Chloride) foil 2. PVDC(poly vinyl dichloride foil) foil. Thickness of PVC foil 0.250mm. 2. ALUMINIUM FOIL Thickness of aluminum foil 0.075mm.

 PVC

forming temp. - 180C Sealing heater temp. - 202C (PVC & alum. Foil) Air required - 4kg (for start the machine) Max. Speed 100rpm Working speed - 70rpm

 In

which both side of tablet/capsule strips aluminium foil is used. Thickness of alu. Foil - 0.020mm to 0.045mm

 Forming

temp. - 180C Sealing temp. - 200C Max. Speed 35rpm Working speed 20rpm

 Protect

against all adverse external influences that can alter the properties of product. Protect against biological contamination. Protect against physical damage. Carry the correct information and identification of product.

 1.MULTI

JET WASHING MACHINE Capacity 190 (ampoules

washed at one time) WASHING CYCLE TIME : 60 Seconds(Approximately- Can Be

Customize)

NO. OF CYCLES/ HOUR : 25 to 30 ( Depend Upon the Speed of Operator

or Method Of Loading & Un-Loading)

USES- The machine is flexible to wash 1ml to25ml Ampoule & 2ml to 10ml Vial with the help of suitable individual trays.

 Suitable

for 2ml to 30ml vials. Washing by Air , DM Water, WFI. Speed 150 to 200 rpm.

 1.DHS

(Dry Heat Sterilization)

2.

MHS (Moist heat sterilization)

 DHS

done by hot air oven . Temp required - 250C Time 2hrs Capacity of hot air oven 90 trays (24000 vials ) Used for ampoules , vials ,glass instruments

 It

is done by AUTOCLAVE. Steam inlet 15lb/cm2. Temp - 121C Time 30mins. Used for production machine parts , rubber plugs, dresses etc.

 CONDITIONS

FOR BETA LACTUM DRY POWDER

FILLING Temperature 23to 27C Humidity - below 23% CONDITIONS FOR NON BETA LACTUM LIQUID FILLING Temperature 23to 27C Humidity - 45 to 55%

 Filling

of liquid into ampoules by 6 nozzles. Sealing is done by LPG + oxygen. Output 6000/hr USeful For 2 ml to 10ml ampoules

 Speed

100rpm Useful for 2ml to 100ml vials. Nozzles 6 ( for filling of liquid into vials)

 It

contain different size of pot wheels according to vials capacity & piston which transfer the powder into vials by the help of pressure and nitrogen gas. Machine speed 140rpm.

 100

class A filling area under LAF (laminar air flow). 1000 class B surrounding of filling area not under LAF. 10000 class C collider , batch room, air lock 2nd and 3rd . 100000 class D packing area , washing area, air lock 1st .

 Beta

Lactum Injections Cefx-500 and 1000 (Ceftriaxonal sodium) Ampicillin Non Beta Lactum Injection Pantaprozole Diclofam

GLASS USED
Glass is composed of sand, soda ash, limestone,& cullet. Si, Al, B, Na, K, Ca, Mg, Zn & Ba are generally used into preparation of glass ADVANTAGE:  They are transparent.  They have good protection power.  They can be easily labelled. DISADVANTAGE:  Glass is fragile so easily broken.  Release alkali to aqueous prerparation.

Harwinder kumar

TYPE OF GLASS:
I. COLOURED GLASS OR AMBER GLASS

II. SULPHURED GLASS III. BOROSILICATE GLASS IV. TREATED SODALIME GLASS V. REGULAR SODALIME GLASS VI. GENERAL PURPOSE SODALIME GLASS

Harwinder kumar

1. 2.

3. 4.

All staff members are highly educated. All types of pharmaceutical machines are available. Machine Operators are very experienced. All departments are present i.e. QA,QC, Tablet , capsule , ointment , jelly & injection production area.

 Drinking

water is not good. Water is filled beside the industry. No place for waste material storage.