HEMATOPATHOLOGY

MODULE

Prepared by
Emmanuel R. de la Fuente, M.D.
 SITUATIONAL
ANALYSIS NO.1
RJ, a 22 yr. old man had a routine
complete blood count.
Slide 1. RJ’s peripheral blood smear showed the
following cells. Identify and describe the red
blood cells. leukocytes, and platelets.
The complete blood count was
reported as normal. What does a
normal CBC and leukocyte
differential count mean?
Discuss also the following:
3.Origin and development of these
cells
4.Control of hematopoiesis
Slide 2. Normal bone marrow biopsy. Estimate
the fat to cell ratio in A. Identify and describe the
precursor cells of the peripheral blood cells in
pictures B, C, and D (next slide) .

A B
Slide 3

C D
 SITUATIONAL
ANALYSIS NO.2
A 32 year old man complaining of
easy fatigability underwent a
bone marrow biopsy because of
an abnormal peripheral blood
smear.
Slide 1. Describe the bone marrow biopsy.
1.Describe the probable peripheral
blood count.
2.Predict the other clinical signs
and symptoms of the patient and
the pathophysiologic basis.
3.Give the probable diagnosis of
the case based on the bone
marrow biopsy.
4.Discuss the etiopathogenesis.
 SITUATIONAL
ANALYSIS NO. 3
A 25 year old man complained of easy
fatigability, weakness, and spontaneous
gum bleeding. A bone marrow biopsy
was performed.
Slide 1. Which of the two biopsies can explain the
signs and symptoms of the patient? Describe each
and explain your choice.

A B
Slide 2. The peripheral blood smear showed this cell
type with a count of 75,000/cu.mm. Which of the 2
previous bone marrow biopsies would be consistent
with this blood picture. Describe the cells below..
Physical examination revealed slightly
enlarged cervical and axillary lymph
nodes and liver. The spleen was not
palpable.
Discuss the following:
2.Probable CBC picture
3.Correlation of bone marrow and
blood picture with the signs and
symptoms
4.Possible diagnoses
5.Possible etiopathogenesis of the
lesion
6.Outcome
 SITUATIONAL
ANALYSIS NO. 4
A 52 year old woman complained of
chronic back pains. CBC showed
moderate anemia. A bone marrow
biopsy was done.
Slide 1. Bone marrow biopsy: A. low and B. high
magnifications. C. bone marrow aspirate. Identify the
cells and describe.

A B C
Slide 2. Typical X-ray picture and skull lesions of
this disease. Identify the lesions and describe.
Discuss the following:
2.Etiopathogenesis of the disease
3.Pathophysiologic basis of signs and
symptoms based on bone marrow
picture
4.Immunologic characteristics of cells
5.Outcome
 SITUATIONAL
ANALYSIS NO. 5
An 8 year old boy had bilateral
cervical lymphadenopathies.
Chest X-ray showed enlarged
hilar lymph nodes. A cervical
lymph node biopsy was done.
Slide 1. Identify and describe the lesion. Is it
benign or malignant? Discuss histologic basis.
Discuss the following:
2.Etiopathogenesis
3.Predominant type of lymphocyte
involved in the lesion
Slide 2. If this is the lesion, identify the cells. Is
it benign or malignant? Give basis for choice.
A. low B. high magnification.
Discuss the following:
2.Probable diagnosis
3.Etiopathogenesis
4.Classification of lesion
5.Basis of staging
6.Outcome
Slide 3. If the lesion shows this type of cell, what
is the probable diagnosis?
Discuss the following:
2.Probable diagnosis
3.Etiopathogenesis of the lesion
4.Classification of the disease
5.Basis of staging
6.Outcome