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Ogan Gurel, MD

Biology 301
Lecture # 14
Roosevelt University

Biology 301
Cellular and Molecular Biology
Spring 2002

Lecture # 14: Plasma Membrane Structure &


Transport Channels
Ogan Gurel, MD
Biology 301
Lecture # 14
Roosevelt University

Overall outline
 Cell membrane structure
 Transport proteins
Ogan Gurel, MD
Biology 301
Lecture # 14
Roosevelt University

Cell membrane structure


 Phospholipid structure
 Artificial membranes
 Two models of membrane structure
 Evidence for the fluid mosaic model
 The fluidity of membranes
 Evidence for lateral mobility
 Detailed structure
 Structure of a transmembrane protein
 Membrane protein functions
 Membrane topology
 The signal mechanism for the synthesis of membrane-
bound & extracellular proteins
Ogan Gurel, MD
Biology 301
Lecture # 14

Phospholipid structure
Roosevelt University
Ogan Gurel, MD
Biology 301
Lecture # 14

Artificial membranes
Roosevelt University
Two models of membrane Ogan Gurel, MD
Biology 301
Lecture # 14

structure
Roosevelt University
Evidence for the fluid Ogan Gurel, MD
Biology 301
Lecture # 14

mosaic model
Roosevelt University
Ogan Gurel, MD
Biology 301
Lecture # 14

The fluidity of membranes


Roosevelt University
Ogan Gurel, MD
Biology 301
Lecture # 14
Roosevelt University

Evidence for lateral mobility


Ogan Gurel, MD
Biology 301
Lecture # 14
Roosevelt University

Detailed structure
Structure of a Ogan Gurel, MD
Biology 301
Lecture # 14

transmembrane protein
Roosevelt University
Ogan Gurel, MD
Biology 301
Lecture # 14

Membrane protein functions


Roosevelt University
Ogan Gurel, MD
Biology 301
Lecture # 14

Membrane topology
Roosevelt University
Ogan Gurel, MD
Biology 301

The signal mechanism for the synthesis of Lecture # 14


Roosevelt University

membrane-bound & extracellular proteins


Ogan Gurel, MD
Biology 301
Lecture # 14
Roosevelt University

Transport proteins
 Diffusion of solutes
 Osmosis
 Osmotic regulation in cells
 Kinetics of facilitated diffusion
 A model for facilitated diffusion
 Active transport: the Na-K pump
 Active & passive transport compared
 Cotransport
 An electrogenic pump
 Types of endocytosis
 Receptor-mediated endocytosis
Ogan Gurel, MD
Biology 301
Lecture # 14

Diffusion of solutes
Roosevelt University
Ogan Gurel, MD
Biology 301
Lecture # 14

Osmosis
Roosevelt University
Ogan Gurel, MD
Biology 301
Lecture # 14

Osmotic regulation in cells


Roosevelt University
Kinetics of facilitated Ogan Gurel, MD
Biology 301
Lecture # 14

diffusion
Roosevelt University
A model for facilitated Ogan Gurel, MD
Biology 301
Lecture # 14

diffusion
Roosevelt University
Active transport: the Na-K Ogan Gurel, MD
Biology 301
Lecture # 14

pump
Roosevelt University
Active & passive transport Ogan Gurel, MD
Biology 301
Lecture # 14

compared
Roosevelt University
Ogan Gurel, MD
Biology 301
Lecture # 14

Cotransport
Roosevelt University
Ogan Gurel, MD
Biology 301
Lecture # 14

An electrogenic pump
Roosevelt University
Ogan Gurel, MD
Biology 301
Lecture # 14

Types of endocytosis
Roosevelt University
Receptor-mediated Ogan Gurel, MD
Biology 301
Lecture # 14

endocytosis
Roosevelt University