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Rishika
Properties
Self renewal - the ability to go through numerous cycles of cell division while maintaining the undifferentiated state Potency the capacity to differentiate into specialized cell types.
by the first few divisions of the cell . So can form any cell of the embryo as well as the placenta.
Pluripotent these cells differentiate
into cells derived from the three germ cell layers. Eg: embryonic stem cell, embryonic germ cell and embryonic carcinoma cells.
cells of a closely related family of cells. Eg: haematopoeitic stem cells, neural and mesenchymal stem cells.
Unipotent these cells only produce
one cell type., but have the property of self renewal which distinguishes them from the non stem cells.
Special sauce Special sauce (largely unknown) (largely unknown) Liver Liver Heart Heart repaired repaired
Kidney Kidney
Sources of human neural stem cells for research and cell therapy
Express the enzyme telomerase (required to maintain the ends of chromosomes) and Oct4 (a master regulator of ESC pluripotency) Maintain normal chromosome structure and complement even after long periods in culture (unlike many other tissue culture cell lines)
In the 3-5 day-old embryo, a blastocyst, stem cells in developing tissues give rise to the multiple specialized cell types that make up the heart, lung, skin, & other tissues. In some adult tissues, such as BM, muscle, & brain, discrete populations of adult stem cells generate replacements for cells that are lost through normal wear and tear, injury, or disease.
Discovered true stem cells in fat that could create new tissues like bone and cartilage
Fix fractures
High healing cell count No culturing required 1000X stem cell concentration as bone marrow Family of healing cells - heterogeneous Rapid, Easy to access Over 1700 peer reviewed papers published
Parkinsonism
PD (2%) >65 years of age. PD is caused by a progressive degeneration & loss of DA-producing neurons. It is thought that PD may be the 1st disease to be amenable to t/t using stem cell transplantation. Factors supporting it - knowledge of the specific cell type needed to relieve symptoms of the disease.
Regarding human stem cell therapy, scientists are developing a number of strategies for producing DA neurons from human stem cells in laboratory for transplantation disease. into humans with Parkinson's
Multiple sclerosis
Multiple sclerosis - acquired neurological disability. Most patients develop a multifocal relapsing-remitting form of disease, followed by secondary progression.
Inflammatory demyelination dominates during the relapsing-remitting stage & neuro-degeneration represents the principle substrate of progression.
stem
cells
may
therefore implanting
replacement-
Studies have found that in laboratory animal models, stem cell injections were able to positively affect motility but the results were most significant with the lowest elapsed time between the injury and the injections.
It is hoped that this research offers some hope to those who are wheelchair bound from spinal cord injuries.
Diabetes
In one study, the symptoms of diabetes were reversed within 2 weeks of mice receiving BM stem cell injections. Their high bld sugar levels were reduced to almost normal values & their insulin levels were raised.
Even more interesting was that the cell growth wasnt from the injected cells themselves. Rather, the injected stem cells triggered the production of cells in the recipients own pancreas. The results were particularly fascinating to researchers also because when stem cells were injected in healthy, non diabetic mice, there was no change.
Its almost as though the stem cells were intelligent, in that they sought out the damaged tissue and triggered the new cell growth. Another benefit of using BM stem cells - they can be harvested from patients own BM. This helps to avoid the problems associated with immunological rejection
Bone marrow transplant is used for cancers such as leukemia, lymphoma & myeloma where it allows the marrow to receive fresh and healthy cells, which then multiply and give rise to the different types of blood that are necessary for life. This procedure is often a life saving one for those whose marrow has been destroyed by chemotherapy and radiation.
Disorders that may be treated with stem cell transplantation include: Immune deficiency. Children born with severe immune cell deficiencies
Inherited Severe Blood Cell Diseases. Marrow transplantation is now being used to treat diseases such as thalassemia or sickle cell disease Marrow Failure. Aplastic anemia,
Current
research the
is
focused
on
overcoming
immunological
challenges of cell rejection so that the success rate of a bone marrow transplant can be improved.
Retinal diseases consequences range from mild effects on vision to complete & rapid onset of blindness.
Scientists ve recently been able to direct the growth of photoreceptor cells from stem cells and effectively introduced them into the retina. This progress is encouraging for those who suffer from degenerative retinal diseases because there is the possibility of restoring or saving vision.
Gene therapy involves inserting genes into a persons cells with the aim of providing treatment for a particular disease.
Because a virus places its own genetic material into the host as part of its own replication cycle, it is an effective way to deliver the normal gene into the cell, thereby replacing the abnormal one
Using Stem Cells for Gene Therapy Of the many reasons as to why stem cells hold great potential for successful use in gene therapies, the most important one is the ability to self-renew. It means that the need to provide repeated administrations of gene therapy can be reduced or possibly even eliminated.
What the researchers did may sound unusual, but they took lab mice and removed bits of skin on their heads, creating a wound.
The creation of this wound essentially woke up the Wnt gene signaling the bodys stem cells to also wake up and start functioning. The stem cells moved to the center of the wound to begin healing it and producing hair follicles with new hair growth.
Burn victims tend to endure an enormous amount of pain & frustration from the challenges of healing. Instead of donor tissues being donated, stem cells could be used to produce new and healthy tissues. In burn victims, a very small piece of the skin can be progressively grown, allowing doctors to cover a burn that is often much larger than the original size of the skin piece.
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