Академический Документы
Профессиональный Документы
Культура Документы
Proteasoma
Control
PS-341 (10 M)
Control
PS-341 (10 M)
M G2
Cell Cycle
G1 Apoptosis
G1
PS-341 induces G1 and G2/M arrest, blocking the M-phase activity of Docetaxel
Bortezomib Effects
Stabilization Stabilization Down-regulation Down-regulation Stabilization
Fanucchi, et al. J Clin Oncol 2005; 23(16S): Abs # 7034. Fanucchi et al, ASCO 2004 Abstract 7107
Adversos
Most common adverse events ( grade 3)
Neutropenia: 52% Thrombocytopenia: 63% Anemia: 13% Fatigue: 13%
Low rate of grade 3/4 neuropathy (5%) likely due to low bortezomib dose Grade 5 toxicity: 4 deaths possibly related to treatment
Davies et al., Oral Presentation ASCO 2006