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HOPI
Patient is a 53 year old Indian female who came back 4 days ago from St Lucia after a 8 day vacation and presented to the ER with chief complains of fever with chills since 1 day ,associated with 2-3 episodes of diarrhea on the day of admission.
Fever was high grade, episodic associated with chills and rigors.
Diarrhea was watery large volume 3 episodes since day of admission ,no blood or mucous noticed in stool associated with nausea, no vomiting.
Pertinent negatives
No headaches/retro-orbital pain No recent sick contacts No insect bites No myalgia or arthralgia or rash
Social history
Denies alcohol/smoking/drug use Lives with her children and is on disability secondary to chronic back pain. Family history
Mother diabetes
Father -healthy
Physical exam
VitalsBP-94/51, Pulse 104, RR-18, Temp-100.3
o
General appearance
Calm and comfortable ,in no acute distress, age appropriate Indian female who was alert, awake and oriented to time place and person
Head AT/NC
Pupils-PERRLA No pallor/icterus
Neurological
AA0*3, Cranial nerve intact Deep tendon reflexes 2+ b/l Babinski sign negative
Labs
BMP Na + -134,K+3.5, BUN-10,creatinine-0.83, Chloride-99,bicarbonate-26
CBC
UA
UA Trace protein Bacteria moderate Leukocyte esterase large
WBC- 10-20
Epithelial cells -few
Liver panel Total protein 7.3,albumin 3.6 T .bili -0.7, D.bili-0.1 AST-31,ALT-13, ALP-71
Chest x-ray
No infiltrate/no cardiomegaly
EKG- normal sinus rhythm
investigations
Iron studies
Stool studies For ova parasites, leukocytes, occult blood , c.
difficile
Malaria prep
US abdomen
Differential
Travellers diarrhea
o
UTI Malaria
Dengue fever
Hepatitis A
management
Ciprofloxacin 400 mg IV q12 Fluid resuscitation Results of investigations orders
Platelet trend
200 180 160 140
120
K/UL
100
80 60 40 20 0 admission day1 day2 day3 day4 ay5
Further investigations
Dengue fever antibodies IgG and IgM Hemoglobinopathy evaluation
investigtions
Day admission 1 2 3 4, 6 AM WBC 4.8 3.0 2.9 3.3 3.2 Platelets 200 166 165 132 48 Temp(max) 100.3 100.1 102.7 101.3 100.3
4 ,1 PM 5
6 7 8
3.3 4.6
5.2 5.8 7.5
44 33
43 60 97
97.9 97.9
97.5 98 98
Follow up
Patient was initially scheduled for follow up at medical clinic and with hem/onc for further evaluation of thalassemia trait, however patient being a resident of Brooklyn wanted to follow up with her PMD. Patient was explained to return to ER if any warning signs of blood loss.
DENGUE
Epidemiology
Some 1.8 billion (more than 70%) of the population at risk for dengue worldwide live in member states of the WHO South-East Asia Region and Western Pacific Region, which bear nearly 75% of the current global disease burden due to dengue
In this sub region 3.9% (168 819) of the cases of dengue were notified, with 2217 DHF cases and 284 deaths
North American countries The majority of the notified cases of dengue in Canada and the United States are persons who had travelled to endemic areas in Asia, the Caribbean, or Central or South America (2). From 2001 to 2007, 796 cases of dengue were reported in the United States, the majority imported. Nevertheless, outbreaks of dengue in Hawaii have been reported, and there were outbreaks sporadically with local transmission in Texas at the border with Mexico
(2)Centers for Disease Control and Prevention. Travel-associated dengue -- United Sta Morbidity and Mortality Weekly Report, 2006, 55(25):700--702.
Information about dengue in travellers, using sentinel surveillance, can be shared rapidly to alert the international community to the onset of epidemics in endemic areas The information can also assist clinicians in temperate regions -- most of whom are not trained in clinical tropical diseases -- to be alert for cases of dengue fever in ill returned travellers. The clinical manifestations and complications of dengue can also be studied in travellers (most of them adult and non-immune) as dengue may present differently compared with the endemic population (most of them in the pediatric age group and with preexisting immunity)
Transmission
The virus
1. Dengue virus (DEN) is a small single-stranded
RNA virus comprising four distinct serotypes (DEN-1 to -4). These closely related serotypes of the dengue virus belong to the genus Flavivirus, family Flaviviridae.
2. The mature particle of the dengue virus is
spherical with a diameter of 50nm containing multiple copies of the three structural proteins,
The vector
The various serotypes of the dengue virus are transmitted to humans through the bites of infected Aedes mosquitoes, principally Ae. aegypti. This mosquito is a tropical and subtropical species widely distributed around the world, mostly between latitudes 35 0N and 35 0S.
The immature stages are found in water-filled habitats, mostly in artificial containers closely associated with human dwellings and often indoors
Studies suggest that most female Ae. aegypti may spend their lifetime in or around the houses where they emerge as adults. This means that people, rather than mosquitoes, rapidly move the virus within and between communities.
The Host
After an incubation period of 4--10 days, infection by any of the four virus serotypes can produce a wide spectrum of illness, although most infections are asymptomatic or subclinical Primary infection is thought to induce lifelong protective immunity to the infecting serotype . Individual risk factors determine the severity of disease and include secondary infection, age, ethnicity and possibly chronic diseases (bronchial asthma, sickle cell anaemia and diabetes mellitus)
Seroepidemiological studies in Cuba and Thailand consistently support the role of secondary heterotypic infection as a risk factor for severe dengue, although there are a few reports of severe cases associated with primary infection (4,5,6,7). The time interval between infections and the particular viral sequence of infections may also be of importance. Antibody-dependent enhancement (ADE) of infection has been hypothesized (8,9) as a mechanism to explain severe dengue in the course of a secondary infection and in infants with primary infections.
Host genetic determinants might influence the clinical outcome of infection (10,11), though most studies have been unable to adequately address this issue. Studies in the American region show the rates of severe dengue to be lower in individuals of African ancestry than those in other ethnic groups. (11)
10. Kouri GP, Guzman MG. Dengue haemorrhagic fever/dengue shock syndrome from the Cuban epidemic, 1981. Bulletin of the World Health Organization, 1989 67(4):375--380. 11. Sierra B, Kouri G, Guzman MG. Race: a risk factor for dengue hemorrhagic fe Archives of Virology, 2007, 152(3):533--542.
The dengue virus enters via the skin while an infected mosquito is taking a bloodmeal.
During the acute phase of illness the virus is present in the blood and its clearance from this compartment generally coincides with defervescence.
Humoral and cellular immune responses are considered to contribute to virus clearance via the generation of neutralizing antibodies and the activation of CD4+ and CD8+ T lymphocytes.
Plasma leakage, haemoconcentration and abnormalities in homeostasis characterize severe dengue. Plasma leakage, haemoconcentration and abnormalities in homeostasis characterize severe dengue.
Recent data suggest that endothelial cell activation could mediate plasma leakage (12,13).
Plasma leakage is thought to be associated with functional rather than destructive effects on endothelial cells.
Activation of infected monocytes and T cells, the complement system and the production of mediators, monokines, cytokines and soluble receptors may also be involved in endothelial cell dysfunction. 13. Cardier JE et al. Proinflammatory factors present in sera from patients with ac
dengue infection induce activation and apoptosis of human microvascular endoth cells: possible role of TNF-alpha in endothelial cell damage in dengue. Cytokine, 30(6):359--365.
Thrombocytopenia may be associated with alterations in megakaryocytopoieses by the infection of human hematopoietic cells and impaired progenitor cell growth, resulting in platelet dysfunction (platelet activation and aggregation), increased destruction or consumption (peripheral sequestration and consumption). Hemorrhage may be a consequence of the thrombocytopenia and associated platelet dysfunction or disseminated intravascular coagulation.
In summary, a transient and reversible imbalance of inflammatory mediators, cytokines and chemokines occurs during severe dengue, probably driven by a high early viral burden, and leading to dysfunction of vascular endothelial cells, derangement of the haemocoagulation system then to plasma leakage, shock and bleeding.
After this extrinsic incubation period, the virus can be transmitted to other humans during subsequent probing or feeding. Thereafter the mosquito remains infective for the rest of its life.
Ae. aegypti is one of the most efficient vectors for arboviruses because it is highly anthropophilic, frequently bites several times before completing oogenesis, and thrives in close proximity to humans.
Clinical Manifestations
For a disease that is complex in its manifestations, management is relatively simple, inexpensive and very effective in saving lives so long as correct and timely interventions are instituted. The key is early recognition and understanding of the clinical problems during the different phases of the disease, leading to a rational approach to case management and a good clinical outcome.
14. Rigau-Perez JG et al. Dengue and dengue haemorrhagic fever. Lancet, 1998, 352:971977. 15. Kalayanarooj S et al. Early clinical and laboratory indicators of acute dengue illness. Journal of Infect 1997, 176:313321. 16 Phuong CXT et al. Evaluation of the World Health Organization standard tourniquet test in the diagno dengue infection in Vietnam. Tropical Medicine and International Health, 2002, 7:125132.
Critical phase
Around the time of defervescence, when the temperature drops to 37.538oC or less and remains below this level, usually on days 37 of illness, an increase in capillary permeability in parallel with increasing hematocrit levels may occur (17,18). This marks the beginning of the critical phase. The period of clinically significant plasma leakage usually lasts 2448 hours. Progressive leukopenia (15) followed by a rapid decrease in platelet count usually precedes plasma leakage.
At this point patients without an increase in capillary permeability will improve, while those with increased capillary permeability may become worse as a result of lost 17. Srikiatkhachorn A et al. Natural history of plasma leakage in dengue hemorrha plasma volume.
: a serial ultrasonic study. Pediatric Infectious Disease Journal, 2007, 26(4):283
Shock occurs when a critical volume of plasma is lost through leakage. It is often preceded by warning signs. In addition, severe organ impairment such as severe hepatitis, encephalitis or myocarditis and/or severe bleeding may also develop without obvious plasma leakage or shock (19). those who improve after defervescence are said to have non-severe dengue. Those who deteriorate will manifest with warning signs. This is called dengue with warning signs . Cases of dengue with warning signs will probably recover with early intravenous rehydration. Some cases will deteriorate to severe dengue (see below).
19. Martinez-Torres E, Polanco-Anaya AC, Pleites-Sandoval EB. Why and how with dengue die? Revista cubana de medicina tropical, 2008, 60(1):4047.
Recovery phase
If the patient survives the 2448 hour critical phase, a gradual reabsorption of extravascular compartment fluid takes place in the following 4872 hours. General well-being improves, appetite returns, gastrointestinal symptoms abate, haemodynamic status stabilizes and diuresis ensues. Some patients may have a rash of isles of white in the sea of red (20). Some may experience generalized pruritus. The haematocrit stabilizes or may be lower due to the dilutional effect of reabsorbed fluid. White blood cell count usually starts to rise soon after defervescence but the recovery of platelet count is typically later than that of white blood cell count.
Severe dengue
Severe dengue is defined by one or more of the following:
(i) plasma leakage that may lead to shock (dengue shock) and/or fluid accumulation, with or without respiratory distress, and/or (ii) severe bleeding, and/or
(iii) severe organ impairment.
Uniquely, the diastolic pressure rises towards the systolic pressure and the pulse pressure narrows as the peripheral vascular resistance increases. Patients in dengue shock often remain conscious and lucid. The inexperienced physician may measure a normal systolic pressure and misjudge the critical state of the patient. Finally, there is decompensation and both pressures disappear abruptly.
Severe dengue should be considered if the patient is from an area of dengue risk presenting with fever of 27 days plus any of the following features:
There is evidence of plasma leakage, such as: high or progressively rising haematocrit; pleural effusions or ascites; circulatory compromise or shock (tachycardia, cold and clammy extremities, capillary refill time greater than three seconds, weak or undetectable pulse, narrow pulse pressure or, in late shock, unrecordable blood pressure).
There is significant bleeding. There is an altered level of consciousness (lethargy or restlessness, coma, convulsions). There is severe gastrointestinal involvement (persistent vomiting, increasing or intense abdominal pain, jaundice). There is severe organ impairment (acute liver failure, acute renal failure, encephalopathy or encephalitis, or other unusual manifestations, cardiomyopathy) or other unusual manifestations.
Management
Investigations
A full blood count should be done at the first visit. A haematocrit test in the early febrile phase establishes the patients own baseline haematocrit. A decreasing white blood cell count makes dengue very likely. A rapid decrease in platelet count in parallel with a rising haematocrit compared to the baseline is suggestive of progress to the plasma leakage/critical phase of the disease..
Diagnostic criteria
Highly suggestive IgM + in a single serum sample
Group A
These are patients who are able to tolerate adequate volumes of oral fluids and pass urine at least once every six hours, and do not have any of the warning signs, particularly when fever subsides. Ambulatory patients should be reviewed daily for disease progression (decreasing white blood cell count, defervescence and warning signs) until they are out of the critical period:
Instruct the care-givers that the patient should be brought to hospital immediately if any of the following occur: no clinical improvement, deterioration around the time of defervescence,
Admission criteria
pregnancy,
infancy, old age, diabetes mellitus, renal failure,
Group C
Patients require emergency treatment and urgent referral when they are in the critical phase of disease, i.e. when they have: severe plasma leakage leading to dengue shock and/or fluid accumulation with respiratory distress; severe haemorrhages; severe organ impairment (hepatic damage, renal impairment, cardiomyopathy, encephalopathy or encephalitis).
Treatment of hemorrhage
Severe bleeding can be recognized by: persistent and/or severe overt bleeding in the presence of unstable
haematocrit of <30% as a trigger for blood transfusion, as recommended in the Surviving Sepsis Campaign Guideline (21), is not applicable to severe dengue. The reason for this is that, in dengue, bleeding usually occurs after a period of prolonged shock that is preceded by plasma leakage.
Give 510ml/kg of fresh-packed red cells or 10 20 ml/kg of fresh whole blood at an appropriate rate and observe the clinical response. It is important that fresh whole Surviving fresh red 21. Dellinger RP, Levy MM, Carlet JM.blood orSepsis Campaign: internation guidelines for given. cells are management of severe sepsis and septic shock: 2008.
Critical Care Medicine, 2008, 36:296327.
There is little evidence to support the practice of transfusing platelet concentrates and/or freshfrozen plasma for severe bleeding. It is being practiced when massive bleeding can not be managed with just fresh whole blood/freshpacked cells, but it may exacerbate the fluid overload.
It should be noted that prophylactic platelet transfusions for severe thrombocytopenia in otherwise haemodynamically stable patients have et al. Preventive transfusion effective and are not 22. Lum Lnot been shown to be in dengue shock syndrome is it neces Journal of Pediatrics, 2003, 143:682684. 54 necessary (22).
Discharge criteria
Clinical No fever in 48 hours Improvement in clinical status Laboratory criteria
References
(1) . PAHO. Plan continental de ampliacion e intensificacion del combate al Aedes aegypti. Informe de un grupo de trabajo, Caracas, Venezuela. Abril 1997. Washington, DC, Pan American Health Organization, 1997 (Document OPS/HCP/HCT/90/97, in Spanish) (http://www.paho.org/Spanish/AD/DPC/CD/doc407.pd f)
(2)Centers for Disease Control and Prevention. Travel-associated dengue -- United States, 2005. Morbidity and Mortality Weekly Report, 2006, 55(25):700--702.
References
(3)Schwartz E. Seasonality, annual trends, and characteristics of dengue among ill returned travelers, 19972006. Emerging Infectious Diseases, 2008, 14(7).
(4) Halstead SB, Nimmannitya S, Cohen SN. Observations related to pathogenesis of dengue hemorrhagic fever. IV. Relation of disease severity to antibody response and virus recovered. Yale Journal of Biology and Medicine, 1970, 42:311328. (5) Sangkawibha N et al. Risk factors in dengue shock syndrome: a prospective epidemiologic study in Rayong, Thailand. I. The 1980 outbreak. American Journal of Epidemiology, 1984;120:653--669.
(6) Guzman MG et al. Epidemiologic studies on dengue in Santiago de Cuba, 1997. American Journal of Epidemiology, 2000, 152(9):793--799.
References
7. Halstead SB. Pathophysiology and pathogenesis of dengue haemorrhagic fever. In: Thongchareon P, ed. Monograph on dengue/dengue haemorrhagic fever. New Delhi, World Health Organization, Regional Office for South-East Asia, 1993 (pp 80--103).
8. Halstead SB. Antibody, macrophages, dengue virus infection, shock, and hemorrhage: a pathogenetic cascade. Reviews of Infectious Diseases, 1989, 11(Suppl 4):S830-S839. 9. Halstead SB, Heinz FX. Dengue virus: molecular basis of cell entry and pathogenesis, 25-27 June 2003, Vienna, Austria. Vaccine, 2005, 23(7):849--856.
10. Kouri GP, Guzman MG. Dengue haemorrhagic fever/dengue shock syndrome: lessons from the Cuban epidemic, 1981. Bulletin of the World Health Organization,
References
11. Sierra B, Kouri G, Guzman MG. Race: a risk factor for dengue hemorrhagic fever. Archives of Virology, 2007, 152(3):533--542. 12. Avirutnan P et al. Dengue virus infection of human endothelial cells leads to chemokine production, complement activation, and apoptosis. Journal of Immunology, 1998, 161:6338--6346.
13. Cardier JE et al. Proinflammatory factors present in sera from patients with acute dengue infection induce activation and apoptosis of human microvascular endothelial cells: possible role of TNF-alpha in endothelial cell damage in dengue. Cytokine, 2005, 30(6):359--365.
16 Phuong CXT et al. Evaluation of the World Health Organization standard tourniquet test in the diagnosis of dengue infection in Vietnam. Tropical Medicine and International Health, 2002, 7:125132.
17. Srikiatkhachorn A et al. Natural history of plasma leakage in dengue hemorrhagic fever: a serial ultrasonic study. Pediatric Infectious Disease Journal, 2007, 26(4):283 290. 18. Nimmannitya S et al. Dengue and chikungunya virus infection in man in Thailand, 196264. Observations on hospitalized patients with haemorrhagic fever. American Journal of Tropical Medicine and Hygiene, 1969, 18(6):954 971. 19. Martinez-Torres E, Polanco-Anaya AC, Pleites-Sandoval
References
20. Nimmannitya S. Clinical spectrum and management of dengue haemorrhagic fever. Southeast Asian Journal of Tropical Medicine and Public Health, 1987, 18(3):392 397. 21. Dellinger RP, Levy MM, Carlet JM. Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008. Critical Care Medicine, 2008, 36:296327.
22. Lum L et al. Preventive transfusion in dengue shock syndrome is it necessary? Journal of Pediatrics, 2003, 143:682684. 54