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What is Cushings Syndrome? A syndrome caused by an increased production of ACTH from a tumor of the adrenal cortex or of the anterior lobe of the pituitary gland, or by excessive intake of glucocorticoids.
Risk Factors
Immune Function Decreased inflammatory responses Impaired wound healing Increased susceptibility to infection
Skeletal Fracture Osteoporosis Muscular Myopathy Muscle weakness
Endocrine/Metabolic Trunchal obesity Moon face Buffalo hump Sodium retention Hypokalemia Virilization Hirsutism Psychiatric Mood alterations Psychosis
Pathophysiolog y
Increased (Glucocorticoids)
Increase Androgen
VIRILIZATION EDEMA Increase blood vessel constriction Decrease potassium in the body HIRSUTISM
HYPOKALEMIA
HYPERGLYCEMIA
Diagnostic Procedures
Overnight Dexamethasone Suppresion Test
- A test to determine the cause of Cushings syndrome - I mg of Dexamethasone administered orally at 11 pm and plsama cortisol is obtained at 8 am in the morning - False results may occur in some medications such as Estrogen, Antiseizre and Rifampin Plasma ACTH level - ACTH and cortisol level: Pituitary disease - ACTH cortisol level: Adrenal Disease
24-hour Urinary Free Cortisol Level CT-scan & MRI - To localize sdrenal tissue and detect tumors
Medical management
Restriction
Pharmacologic Management
Adrenal Enzyme Inhibitor (Ex. Metopirone, Cytadren, Lysodren) - To reduced hyperadrenalism by inhibiting cortisol synthesis - Administered with meals Hydrocortisone - Post-op: temporary replacement therapy after surgery
Nursing Management
Establish protective environment Encourage high protein, calcium and vitamin D foods to avoid muscle wasting and osteoporosis Low sodium diet
Avoid direct application of adhesive tape to the skin and skin care is necessary Encourage the patient and the family to verbalize feelings and concerns Monitor fos signs and symptoms of Addisonian crisis