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Sistem ekskresi pada manusia dan vertebrata lainnya melibatkan organ paru-paru, kulit, ginjal, dan hati. Namun yang terpenting dari keempat organ tersebut adalah ginjal.
HOW THE KIDNEYS WORK The kidneys are two bean-shaped organs located toward the back of the body on either side of the spine near the waistline. They are about the size of a fist and are protected by other organs and two of the lower ribs. Normal functioning kidneys serve the body in several very important ways. They: Clean your blood and remove waste products Balance water and salt to control fluid in the body Control blood pressure Help make red blood cells and strong bones Control the amount of potassium, calcium, magnesium and phosphorus in the blood
Introduction
The
This system contributes to the maintenance of homeostasis by complex process that involves, (nephron)
Filtration
of most small molecules from blood plasma to form an ultrafiltrate of plasma. Selective reabsorption of most of the water and some other molecule from ultrafiltrate, leaving behind excess and water material to be excreted. Secretion of some excretory products directly from blood into urine. Maintenance of the acid-base balance by selective of H+ ions into the urine.
The kidney also participates in other homeostatic mechanisms either by production or by modification of various hormones:
Renin,
is component of the reninangiotensin-aldosteron mechanism which control blood pressure. Erythropoietin, synthesised in the kidney, stimulated the production of erythrocytes in the bone marrow and thus regulated the oxygen-carrying capacity of the blood. Vitamin D, which regulated calcium balance, is converted to an active form in the kidney.
124 mL is absorbed in the organ The two kidney produce about 125 mL of filtrate per minute;
Introduction
Urine kidney
retroperitoneal
ureter bladder
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anterior part of the pelvis
Urine is produced in the kidneys and flows down the ureters to the bladder where it is stored until voided via the urethra.
The kidney possess a convex and a concave border, the latter of which is known as the hilum.
The cortical region is subdevided into the cortical labyrinth and the medullary rays.
The medulla is composed of 10-18 renal pyramids, each of whose apex is perforated by 15-20 papillary duct (of Bellini) at the area cribrosa. Each renal pyramid is said to constitute a lobe of the kidney. The region of the medulla between neighboring renal pyramid is occupied by cortical-like material known as renal columns (of Bertin). Each medullary ray is an extension of the renal medulla into the cortex, where it forms the core of kidney lobule.
Cortical labyrinth cortex Medullary ray KIDNEY Zona eksterna medulla Zona interna
Histologic organization of the kidney
Corpus malphigi Tubulus contortus primus Tubulus contortus secundus Ductus colligentes pars arcuata
Tubulus rectus primus Tubulus rectus secundus Ductus colligentes pars rectus
Tubulus rectus primus Thin limb of Henles loop Tubulus rectus secundus Ductus colligentes pars rectus Thin limb of Henles loop Ductus colligentes pars rectus Ductus papillaris Bellini
Cortical Labyrinth Corpus Malpighi Tubulus Contortus Primus Tubulus Contortus Secundus Ductus Colligentes pars Arcuata
Medullary Rays Tubulus Rectus Primus Tubulus Rectus Secundus Ductus Colligentes pars Rectus
Medulla Zona Externa Tubulus Rectus Primus Ansa Henle Segmen Tipis Tubulus Rectus Secundus Ductus Colligentes pars Rectus Medulla Zona Interna Ansa Henle Segmen Tipis Ductus Colligentes pars Rectus Ductus Papillaris Bellini
Excretion unit ( nefron) Collecting tubules : D. Colligentes pars arcuata, D. Colligentes pars rectus, D. Papillaris Bellini.
CORPUS MALPHIGI
Glomerulus
Capsula Bowman Pars Parietal Pars Visceral Vascular Pole Urinary Pole
GLOMERULUS
Pars Visceralis cell Bowman Capsula. Podocytes cell Capillary endothelium Intraglomerular mesangial cell (fagositosis)
Juxtaglomerular apparatus
- Epitel Selapis kubis - Aspek sangat asidofil - Batas sel tak jelas - Letak inti berjauhan - Brush Border - Mitokhodria
TUBULUS RECTUS PRIMUS - Hampir sama Tubulus Contortus I - Tidak berkelok-kelok - Epitel Selapis kubis - Aspek asidofil - Batas sel tak jelas - Letak inti berjauhan - Brush Border - Mitokhodria
-Inti menonjol ke lumen -Bentuk lebih tebal dari endotel -Sedikit brush border -Sitoplasma kurang asidofil -Lumennya lebar
TUBULUS RECTUS SECUNDUS - Tidak berkelok-kelok - Epitel selapis kubis - Inti berdekatan - Sitoplasma sedikit asidofil - Tak ada brush border - Mitokhondria
TUBULUS CONTORTUS SECUNDUS - Kurang berkelok - Epitel selapis kubis - Inti banyak berdekatan - Batas sel tdk jelas - Sitoplasma bergranuler - Kurang asidofil - Brush border - Sedikit mitokhondria
DUCTUS COLLIGENTES - Epitel selapis kubistorak tinggi - Sitoplasma bening - Apical sel terdapat cuticula - Batas sel jelas
TCP TRP PI (Tubulus Contortus (Tubulus (Pars Intermedia) Primus) Rectus Primus) Epitel Selapis torak rendah/kubus Selapis kubus Selapis gepeng
DC (Ductus Colligentes)
Sitoplasma
Sedikit asidofil
Kurang asidofil
Batas sel
Tidak jelas
Tidak jelas
Tidak jelas
Tidak jelas
Tidak jelas
Jelas
Brushborder
(+)
(+)
(-)
(-)
Basal striation
(+)
(+) Sedikit
(+) Sedikit
(+) Sedikit
(-)
Bentuk sayatan
Berkelok
Tidak berkelok
Berkelok
Proximal tubule
Distal tubule
Supporting tissue
Azan x 750
Ductus Papillaris Bellini (The largest of the collecting ducts) Calyx Minor Transitional Epithelium Smooth Muscle
Vasa Afferrent Glomerulus Vasa Efferent Bercabang menjadi Plexus Peritubular dan plexus kapiler di medulla Plexus Peritubuler Venae V. Stellata V. Interlobularis V. Arcuata V. Interlobaris V. Renalis
SISTEM LIMFATIK GINJAL Sistem superficial (dimana cabang kapiler limfe terdapat pd kapsul ginjal dan berhubungan dengan pembuluh ginjal) Sistem Profunda Terletak pada jaringan kelenjar.
Dalam glomerulus tidak ada pembuluh limfe
PERSARAFAN GINJAL
Saraf tak bermielin Berasal dari Plexus Celiaca, Nervus Th X XII & LI mengikuti pembuluh darah dan berakhir pd arteriole glomerulus. Serat saraf sensoris bermielin berjalan menuju kapsul, otot polos pelvis dan Tunika adventisia dari pembuluh darah ginjal. Saraf memasuki ginjal melalui Hilus.
URETER Tn. Mukosa - Epitel - Lm. Propria - Tn. Musk. Muk. Tn. Sub Mukosa Tn. Musc Transisional, sel payung, krusta Jaringan ikat tipis Tidak jelas 2/3 proksimal: long, sirk. 1/3 distal: long,sir,long Tn. Adv Fibroelastika. Pembuluh drh ++
VESIKA URINARIA Transisional, sel payung, krusta + (tipis) Tidak jelas Dlm: Long. Tengah: Sirk. Luar: long.
bladder
ureter
URETHRA PRIA : + 15-20 CM P. Prostatica Tn. Mucosa Epitel M. Basalis Lm. Propria Tn. Musc.muc Tn. submucosa 3-4 cm Transisional Tipis P. Membranacea 1 cm Berlapis bertingkat torak + P. Cavernosa 15 cm Berlps torakbertingkat + JI Jarang Lapisan otot<< Lacunae venae, fibroelastik, o. polos long & sirk Lacunae venae, long & sirkuler. JI fibrosa = Tn. albuginea Berlapis gepeng + JI Jarang P. Navicularis
Tn. Musc.
Fibromusculer
Tn. Adv
URETHRA WANITA : + 4 CM Tn Mucosa: - Epitel transisional (dekat VU), berlapis torak bertingkat torak berlapis gepeng (distal). - Lm. Propria : JI. Jarang, plexus venae - Tn. Musc. Mucosa : Tn submucosa: Tn Muscularis: Longitudinal, sirculer otot sphingster urethrae Tn. Adventitia: -
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