Pharm Chem Faculty Off-Site Meeting Summary

12-14-11 Tiburon Audubon Society Facility

Draft Agenda for December 16 PC Off site:

8:30-9AM: Continental Breakfast 9:00-9:45 AM: State of the Department (Jim and Millo) Vision (Tools and Biology) (Jim) Goals for the day (Jim) Recruiting and space status and challenges (Jim) Departmental Finances and Staff organization (Millo) 9:45-10:30AM: Current teaching responsibilities and challenges for next 3 yrs (Steve, Norm, and Sue to facilitate) What are the current teaching assignments? Are there current gaps? Do we foresee gaps in the next 3 yrs and how would you propose to adjust? Are there programatical changes on the horizon? 10:30-10:45 Break 10:45-noon: Vision for Physical Biology (Al, John, Bo, Tom J; John and Bo will facilitate discussion) Mass Spec Recruitment and facility vision (Jim will update) What are the most exciting prospects for the Physical Biology area and what kind of folks should we recruit to replace Tom when he retires? (John and Bo)
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Noon-1PM: Working Lunch (Dan Santi, how we are faring on industrial collaborations? Can we do better?) 1-2PM: Vision for Quantitative Pharmacology (Matt, Brian, Tom F; Matt will facilitate discussion) Where should we go here and why? What are examples of people we might recruit? What recruiting recommendations would you make and space required?

2-3PM: Vision for Protein Engineering/ Biologics/ Synthetic Biology (Charly, Zev, Xiaokun; Charly and Xiaokun will facilitate discussion) What are the hottest topics that we see in the next 10 yrs that fit with PC? Is there an important distinction between these areas? Who is doing the best work we consider fitting for PC? Should we recruit a junior person here? 3-4PM: Vision for Chemical Biology and Drug Discovery (Bill, Danica, and Pam will facilitate discussion) Should we recruit a junior person here now that CC has retired? How do we augment our current faculty? Should we emphasize synthesis? Should we emphasize drug discovery? Industry vs Acadmic trained? We have a lot of recruiting in other areas can we wait a year or two (assuming James joins)?
4-5: Wine/beer and Top Action items for 2011-2012 (Jim to facilitate)
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Review Agenda and Goal of the Day

Vision - Wells
All agreed on the shared vision taking on the responsibility of being disease agnostic and contributing to the biology and chemistry All felt the burden of shouldering financial liabilities for the entire campus to the technology enabling centers recharge not recovering all costs and department taking on risk of potential deficit LRPD how does the enabling technology centers fit in relation to funding? Depreciation? R&D funding? Advantage of PC faculty being on campus committees research

Outstanding growth opportunities

4 open FTEs (Andrew Krutchinsky, Voigt, Dill, CC) plus fifth when Tom Retires Two open searches:
Computational biologist (Matt) Mass Spec (Al/Jim)

department will be close to half new faculty in near future.

Challenges
#1 Start up Funds:
PC has been successful in partnering with CVRI & using P30 grant and minimize requests to dean and SOM. Mass spec recruitment will be a bigger challenge. Search committee is a lot outside of the department (CMP, CVRI esp) but may want to plan more partnership esp. biochemistry. Of 4 available candidates in the field, 2 are actively being recruited. Strategy to recruitment? Best athlete or more narrow to satisfy void in department? Start up costs indirect cost recovery responsibility, loss to campus when faculty leave before full professorship.

Cont. challenges
#2 - Finding great candidates #3 - Developing new faculty new lab set up has been on track. What are challenges to new faculty? More mentoring? Paul is currently the official mentorship coordinator for the department. Bo and Xiaokun feel mentorship provided is good and are getting help from a variety of people. Pam has stepped up to help new faculty review R01s and was nominated to be the next official mentorship coordinator. ACTION ITEM discuss mentorship at the end of meeting

Cont. challenges
#4: Space
less of a concern given partnership with CVRI and Space in neuroscience building is also a potential. Plan for Parnassus space? could be tradable space/money. Last year of MOU with Susan Fisher 11th floor. Lateral transfer of use within SOP with Clin Pharm going on unofficially.

Highlights from SOP LRDP

Grant revenue highest in Clin Pharm, but PC is doing well and on track to go up given senior recruitment. funding research sources going up in SOP, other public sources is smaller than expected. Majority is federal. Private non-profit has gone down. ICR per PI highest in SOP. SOM second. Student-faculty ratios highest in SOP (11:1) for professional students. Space requests made to chancellor by dean (Mary Anne slide 16).

Finance-Operation
Reviewed bottom-line of department revenue and comp plan. Discussed current staff org chart and plans. Concerned about HR and pre award staff impact by OE.

Teaching
Coordination and teaching load transitioning with retirement Dicks last year on recall (PC 111, 163 student-run) John Gross will be course director next year PC 111 (18) Brian continues 5 Need to identify another lecturer Pam taking over PC 123 To discuss with Paul to add lecturers to PC 114 in the future

Cont. teaching
Apples for Teachers Paul consistently gets 4.5 rating and receive Deans award in large lecture course. Steve and Brian also have been highly rated and honored by dean Adjunct professors have contributed to many courses and valued, but should be at least in 4-5 hour blocks for consistency. Performance now being evaluated on computer. In general SOP did well in Spring 011. Compare departments, PC rated much higher even compared to dedicated teachers in SOM Ilos and CLE-being mandated by dean to help curriculum sharing and accreditation. Faculty facing challenge putting materials online Students are slow to adapt to new system and lecturers work is doubled A few TAs hired as curriculum liaison to help bridge this new process

Physical Biology where should we grow? (Gross & Huang)

Wish list mid year and junior Crystallographer, NMR, EM, long-term support for beamline Need to partner with Biochemistry to coordinate on direction & potentially CVRI or BTS
CVRI hired Natalia and interested in more Jamie Fraser is a potential with BTS

The future
In cell studies of macromolecular dynamics; structure Methods to study complexes and transient interactions Allostery: need innovative approaches to study

 Strengths at UCSF - facility is phenomenal and support is adequate but could be better
NMR facility: DNP, 400, 500, 600(x2)and 800 MHz NMR; solid-state capabilities, Berkeley 900 SLAC and ALS 30 minute drive MSG Centers-HARC, Membrane proteins EM resources

 Opportunities in NMR
NMR of membrane proteins, solids In cell NMR, eukaryotes Allostery, dynamics; drug discovery centric? Innovation in combining methods, x-ray NMR, NMR and microfluidics, NMR and Single-Molecule

Traditional single-molecule biophysics

Single-molecule FRET
TJ Ha, Xiaowei Zhuang and other Steve Chu lab people

Single-molecule tracking
Paul Sevin, Toshio Yanagida

Single-molecule force
Carlos Bustamante, Steve Block

A broader view of single-molecule BP

The physical biology philosophy
High sensitivity, high precision quantitative measurements Physical aspects of biology

Rapidly evolving fields Not necessarily single-molecule Tightly associated to systems biology

The new opportunity

Molecule conformation, dynamics and interactions inside a cell Sunney Xie Examples at UCSF
Orion Weiner Wallace Marshall Ron Vale / Dyche Mullins Sophie Dumont

What to look for in physical biology

Aiming at the philosophy, junior level for new ideas and new techniques Example:
Adam Cohen (I don't think that we will be able to recruit him here)
How can we look for others who are producing results Can we think about grad students that UCSF can provide to them Best athlete approach works for this type of search

Very possible collaboration with Biochemistry or CMP department. Potentially associated with systems biology

Mass Spec Search Update (Wells)

4 people on the market in the field, 2 are too expensive, 2 are not the right fit. Committee want to go after Garcia or Coon. Space in Byers Hall (Voigt space 4N). Challenge is start up package and dean is on board. This recruit is to be the expert for the campus. There is a great need for nuts and bolts person. Technology-capability vs. biology-oriented. Potential transition issue for senior people in the Burlingame lab.

Industry Update (Santi)

Program have been in place for about 2 years and have been affected by recession Brought in large companies and now focusing on local ones about half a dozen. New format to take UCSF faculty to present at companies & mixer at Bayer meeting Formed board in summer to help direction; small benefactors are better than no programs at all.
Connections made so far: Chem group Genentech, Giliard, Bayer To be arranged: Amgen in Jan, Novartis, Merck, Cabo, Biotech conference in MB again next May

XXX (I stepped out at this point during lunch)

UCSF School of Pharmacy LRDP response

Organizing concepts/ major themes

December 14, 2011 Mary Anne Koda-Kimble, Dean UCSF School of Pharmacy

The six LRDP questions

1. Does your school anticipate future growth? How much and where? 2. Would growth be in research or non-research areas? 3. How would the school be optimally arranged across UCSF sites into the future? 4. What would make Parnassus and Mission Bay equally desirable? 5. What aspirations/themes does the school have for Phase 2 at Mission Bay? 6. What considerations should be kept in mind as we start thinking about major site themes for the LRDP?

5/27/2012

Mary Anne Koda-Kimble

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Questions 1 and 2
1. Does your school anticipate future growth? How much and where? 2. Would growth be in research or non-research areas?

We plan to grow in both education and research.

5/27/2012

Mary Anne Koda-Kimble

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Education: Change the face of pharmacy education; Bolster graduate and post-doctoral training
Space is tied to growth in faculty, staff, tools:
Pharm D Program 8 new faculty members (8:1 ratio)
Increase 20/class to 145/class; 500 to 580 total Add 20 post-BS PharmDs (virtual)

PhD, Masters and Post-doctoral fellowship Programs

Expand enrollment as driven by contemporary science and technology (e.g. MTM)

Residency positions
Double from 16 PGY1 to 32 PGY1 Double from 10 PGY2 to 20 PGY2

Learner-centered, modular, virtual programs 20 new educational technologists and related tools

5/27/2012

Advanced pharmacy practice and science ( 100s) Drug development sciences ( 150) Therapeutic sciences (BRIC countries) ( 30 students) Translational medicine
Mary Anne Koda-Kimble 25

Why grow our education enterprise?

More pharmacist leaders, clinicians, and translational research scientists needed worldwide Changes in health care delivery and drug delivery systems Central role of increasingly complex medicines and therapeutics Expanding roles require advanced training for pharmacists in new technologies and how to integrate them into clinical practice UCSF PharmD has been top-ranked for over 30 years and needs to stay ahead of the curve UCSF is the best place to expand and shape pharmacy education: leading edge science, health care, & education in a collaborative environment Increased revenue stream
5/27/2012 Mary Anne Koda-Kimble 26

Question 3
3. How would the School be optimally arranged across UCSF sites in the future?
Department Parnassus
Clinical Pharmacy
Bioengineering and Therapeutic Sciences* Pharmaceutical Chemistry Deans Office*

Mission Bay

Mt. Zion, SFGH

Laurel Heights

Remote sites

Virtual Distance

50%
15%

25%
85% 100%

5%, 10%

5%

5%

yes
yes yes

70%

30%

yes

*Flexible

5/27/2012

Mary Anne Koda-Kimble

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Question 4
4. What would make Parnassus and MB equally desirable from the SOP perspective? Space at both sites: Modern. First rate teaching, clinical, research facilities. Organized by themes. Must have magnet programs. Seamlessly networked by technology Equitable lab, office, and administrative space assignments Scientific cores at each site based on research needs

5/27/2012

Mary Anne Koda-Kimble

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Question 6
6. What considerations should we keep in mind as we start thinking about major site themes in the LRDP? All sites need compelling research themes All sites must have a strong educational component School of Pharmacy research and education must be integrated amongst departments and with other schools at each site Think beyond the current economic situation to what could be.

5/27/2012

Mary Anne Koda-Kimble

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Question 5
5. What aspirations/themes does the SOP have for phase 2 at Mission Bay?

5/27/2012

Mary Anne Koda-Kimble

30

Imagine 15 years from now

Science is thriving within a School of Pharmacy-led research building at Mission Bay that consolidates and incubates therapeutics research and provides broadly accessible enabling technologies campuswide. UCSF at Mission Bay is internationally recognized as the place for innovative therapeutics research that integrates basic, translational and clinical scientists. UCSF at Mission Bay is home to a national think-tank for new directions in therapeutic sciences and technologies -- convening academic, government, and industry leaders on a regular basis. The UCSF Medical Center at Mission Bay is a world-class model for pharmaceutical care and pharmaceutical services. Residency positions are highly competitive.

5/27/2012

Mary Anne Koda-Kimble

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Quantitative Pharmacology (Jacobson)

Bring more basic science into drug discovery. PC to play a leadership role. Existing faculty leaving/has left. Systems biology and industrys vision of the field is not adequate. Brian taking the lead w/ Kathy Giacomini support. Education aspect of program: getting a training grant, combine with pspg potentially and partnering with other ipqb programs. Faculty recruitment not many left of core people in computational biology. Dill FTE search open and would like another FTE and another FTE in BTS.

Action item: Asking for department commitment to launch a search Fall 2012, chaired by Brian (independent from BTS replacing Chao) Matts definition of systems pharmacology (pre-clinical quantitative PK/PD) Target discovery systems biology (aka atoms to cell, systems pharmacology)

Wither Protein Engineering/Synthetic Biology

Pharm Chem Off Site December 14, 2011

Wither Protein Engineering/Synthetic Biology

Engineering small molecules, macromolecules or materials to understand a complex biological system at the systems level.

3. Synthetic Biology/Protein Engineering: Chris Voit presented a compelling case that we are on the verge of a major break-through in developing the machine language for programming cells. UCSF is at a sub-critical mass to carry this out. He proposed hiring a mid-career scientist: Dan Gibson (JCVI), Yi Tang (UCLA), Jeff Hasty (UCSD), Byung-Kwan Cho (KAIST), Tim Lu (MIT). There was strong support to move forward. Actions: Chris should put together a job description and I'll talk with Mary Anne about opening a search this fall.I presented the case for hiring in the Protein Engineering/Biotherapeutics area. Protein selection technologies and biotherapeutics are burgeoning areas relevant to component design for synthetic biology and understanding signaling modules in cells. In the near future biotherapeutics will match or exceed the revenues from small molecules. We have few to no scientists in this area. Several individuals were discussed including: Danny Tawfik (Weizmann Institute), Dev Sidhu (University of Toronto), David Liu (Harvard). There was general support. Action: Jim will discuss this with Kathy/Sarah to see if a joint recruitment would be possible in this area

Should we trim things down and not do a future hire in PE and Synthetic Biology?

Many depts do many things. We should focus on our strengths and build on them and PE and SB fit.

Regarding the Best Athlete Search Concept: Keep the searches broad and attract the best athlete problem is hard to get buy in from X though. So have a general search and then stratify. What we are looking for are exceptional scientists that think chemically (about macromolecules), work collaboratively and interact well.

For synthetic biology, cannot find another Chris right away. Can we bring in people that think about complex systems and who does it from a chemical background. Ex is Zev Examples: How does a complex system work? Look at multiple things at once. Tool development to get at this imaging, quantitative pharmacology, antiproteome, PE, Synthetic Biology, Engineering small molecules or the protein. Protein Engineering-someone like a Tanya K who can make molecules but is not afraid to write code. Another example: Jen Presser (Sam Gambir and Chris Contag) Multimodal imaging agents.

 Junior vs Senior? - Junior people have more plasticity and can change faster in a rapidly developing field than a senior hire. Action item: - Looking for exceptional scientists that think chemically should we reopen the search, should we reorganize the search? - radar should be on even search will be on hold until current 2 searches are finished. - standalone, broad search for best athlete posting in fall 2012 - should we put synthetic search on hold? Dean and Wendell (cmp) have possibility to contribute

Chem Bio & Drug Discovery (DeGrado & England)

James Fraser is a good candidate. Space in CVRI for molecule maker using hood, only 40% of chemistry space is used. Stan Pruisner looking for 5 FTEs in neuro building
How to partner with neuro to bring people in that is part of the broader UCSF Jason ? is another good candidate Jeff Kelly is another person (coming Jan)

-Currently have a tremendous opportunity and UCSF can be adding a couple of hires per year in the next few years.

Action Items

Proposed Hiring's and Space

Dill to Comp Biophys (Matt) 2011 (QB3 or 4N) Krutchinsky to MS (Al/Jim) 2011 (QB3) Voigt to PE/SynBiol 2012 (5S) CC ?? 2013 Scanlon to James Chen 2010 (CVRI) Tom James to Struct Biol with BTS (5S or QB3) 2012 Systems Pharma with BTS (QB3 or 4N) 2012 Chem Biol (CVRI/Neuro) Phys Biol 2013
Green denotes that we have or will have soon open FTEs for these
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Admin Hiring
Jen Paloma took Anemishs position and we will be looking for replacement in 2012 FTE admin addition for PC in CVRI in 2012

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Faculty Meetings
Be more flexible if important matters arise 5-10min max for admin at end Be flexible about PP vs chalk Generate discussion Emphasis on future not past Think about vetting specific aims for proposal

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Mentoring
Connect to faculty Support awards Support grants Bill to meet with Assistants and formulate systematic policy

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Education
Think about possible masters program run from PC in Drug Discovery. Jim to bring up with SoP Leadership Group How will e-education affect us?? Norm to follow up

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