REBRANDING HEMP FOR THE NUTRACEUTICAL MARKET

CANTERPENE AS A HEALTHSPAN EXTENSION SUPPLEMENT

Terry Grossman,M.D. Medical Director Morris Johnson, CTO, Founder Silas Kanning,

Co-founders of:
Lifespan Pharma Inc.

OUR SHAREHOLDERS HAIL FROM AGRICULTURE, MEDICINE AND PHARMACY

Morris/Greg/Leah/Erin

Rod Fisher

Steve Burnside

REBRANDING HEMP AS CANTERPENE MAKES SENSE FOR THE NATURAL HEALTH PRODUCT / DSHEA FOOD SUPPLEMENT MARKETS

35 YEARS AGO RAPESEED EXPERIENCED THE SAME PROBLEMS AFFECTING HEMP TODAY
Growers needed to rebrand something that was associated with a machine oil regarded as too toxic for humans to consume

Low Erucic Acid Rapeseed (LEAR)?

CANadian source of OLeic Acid became CANOLA

It was promoted as a safe, nutritious, multipurpose human and animal food ingredient

Hemp is undergoing a similar identity crisis in the minds of many today

When you Google hemp you get recreational and medicinal marijuana Hits because pot people use hemp indiscriminately when speaking about marijuana

SOME MARIJUANA PRODUCTS associate cannabis with health benefits and socially sexy memes such as organic or chemical free

SOME CANADIAN HEMP PRODUCTS ASSOCIATE HEMP WITH MARIJUANA

ASSOCIATING HEMP WITH MARIJUANA IS CREATING CONSUMER CONFUSION

Solutions:
Litigate?
Regulate? Educate?

Ignore?

AFTER MUCH CONSIDERATION WE CONCLUDED NONE OF THE ABOVE SOLUTIONS ARE PRACTICAL OR COST EFFECTIVE

Some hemp manufacturers want to capitalize on the science which has popularized the term Medical Marijuana The best solution: REBRANDING

REBRAND CANADIAN HEMP AS CANTERPENE

We link Canadian Hemp with the messages: Extend Health-span and Lifespan naturally with cannabis chemistry Canterpene expands functional chemistry beyond arginine and omega3s to include cannabinoids and terpenes

WE HAVE PATENTED CANTERPENE AS A PROPRIETARY FORMULATION OF MILLED HEMPSEED

DOES CANTERPENE HAVE A MARKET?

-Healthspan and lifespan extension are new unmet needs
-Personalized /Individualized Medicine is an emerging Industry -Bockbuster Pharma is migrating towards Niche Pharma -Canterpene Cannabis without THC contains phyto-chemistry which scientific research indicates would make it a useful food supplement for the purpose of

personalized management of AGING

AGING CAN BE BRUTAL

This
Becomes
This--> All Too Soon

IT IS POSSIBLE TO GROW OLDER WITHOUT AGING

AT ANY AGE

60 yrs old

80 yrs old

ANTIAGING IS AN ENORMOUS MARKET

76 million baby boomers in the US 6 million boomies in Canada Boomers now 48 64 and have begun to experience the aging process firsthand This generation has redefined each stage of their lives and is currently redefining aging

BOOMERS REGARD AGING IS A DISEASE

 THAT AFFECTS EVERYONE

 AND IS 100 PERCENT FATAL

THIS IS THE NEW VIEW OF AGING

Bob Delmonteque, age 84

THE TWO PILLARS OF HEALTH

Prevention

Early Detection

CANTERPENE CAN HELP AS A PREVENTIVE ANTIAGING STRATEGY

Science has linked numerous Cannabis compounds found in Canterpene with beneficial effects on the diseases resulting from normal aging

Canterpene captures much that other conventional hemp supplements have ignored

A toolbox for slowing aging & regenerating damage is emerging: e.g. Plastoquinine..targeting oxidative stress

TA65 targeting telomerase gene activation

Food supplements claiming to support stem cell healthspan

STEMCELL100.COM , A NUTRACEUTICAL DEVELOPED BY GENESCIENT CLAIMS TO PROMOTE THE STABILITY AND VITALITY OF ADULT STEM CELLS SO THEY HAVE THE CAPACITY TO DIVIDE WHEN THE BODY SIGNALS A NEED FOR MORE STEM CELLS. CONTAINS: -THEANINE - 5-N-ETHYL-GLUTAMINE FROM CAMELLIA SINESIS -OLIGO-PROANTHOCYANIDINS FROM THE PINE BARK OF THE PINUS TREE -PTEROSTILBENE, WHICH IS A LONG HALFLIFE RESVERATROL ANALOG FROM PTEROCARPUS MARSUPIUM - ASTRAGALOSIDES EXTRACTED FROM ASTRAGALUS MEMBRANACEUS

CAN CANTERPENE WORK AS A HEALTHSPAN AND LIFESPAN EXTENSION TOOL?

CANTERPENE

THE MEDICAL BENEFITS

NUMEROUS BIOCHEMICAL BENEFITS OF CANNABINOIDS IN HEMP

Many terpenes exhibit health benefits

Canterpene is a source of supplemental terpenes

Chemo-profiles of some cannabis varieties

AGING IS NOT LEGALLY CLASSIFIED AS A DISEASE But.

SOME DISEASES/CONDITIONS ASSOCIATED WITH AGING ARE

Oxidative stress Arthritis Central nervous system degeneration

Parkinsons
Alzheimers

Cannabidiol (CBD) the major cannabinoid in hemp has been shown to be of benefit in each of these and many other conditions

OXIDATIVE STRESS
CBD treatment significantly reduced oxidative stress; decreased the levels of tumor necrosis factor, vascular endothelial growth factor, and intercellular adhesion molecule-1; and prevented retinal cell death and vascular hyperpermeability in the diabetic retina. Consistent with these effects, CBD treatment also significantly inhibited p38 MAP kinase in the diabetic retina. These results demonstrate that CBD treatment reduces neurotoxicity, inflammation, and BRB breakdown in diabetic animals. EL Remessey AB et al. Neuroprotective and blood-retinal barrier-preserving effects of cannabidiol in experimental diabetes. Am J Pathol. 2006 Jan;168(1):235-44.

ARTHRITIS
These potentially anti-inflammatory properties of CBD, together with the lack of psychotropic effect and low toxicity prompted us to test the potential of CBD as a therapeutic agent in collagen-induced arthritis (CIA). RESULTS: We report that CBD has a beneficial therapeutic action on established CIA.

Malfait AM et al. The nonpsychoactive cannabis constituent cannabidiol is an oral anti-arthritic therapeutic in murine collagen-induced arthritis. Proc Natl Acad Sci U S A. 2000 Aug 15;97(17):9561-6.

PARKINSONS DISEASE
Evidence suggests that cannabinoids may prove useful in Parkinson's disease by inhibiting the excitotoxic neurotransmitter glutamate and counteracting oxidative damage to dopaminergic neurons Croxford JL. Therapeutic potential of cannabinoids in CNS disease. CNS Drugs. 2003;17(3):179-202. It seems that cannabinoids could delay or even stop progressive degeneration of brain dopaminergic systems, a process for which there is presently no prevention. In combination with currently used drugs, cannabinoids might represent, qualitatively, a new approach to the treatment of PD, making it more effective. Sevcik J, Masek K Potential role of cannabinoids in Parkinson's disease DRUG AGING 16 (6): 391-395 JUN 2000

ALZHEIMERS DISEASE
Memory loss, the first and primary symptom of Alzheimers disease, can be slowed down significantly in mice by cannabidiol. In a study at the Cajal Institute in Madrid, Spain, mice were injected with a molecule found in the brain of humans suffering from Alzheimers disease, and then treated for one week with cannabidiol. Those mice injected with cannabidiol successfully performed the task within 25-30 seconds, compared to control mice, who took almost double the amount of time, 45-50 seconds, to complete the task. See also: Iuvone T, Esposito G, Esposito R, et al. Neuroprotective effect of cannabidiol, a non-psychoactive component from Cannabis sativa, on beta-amyloid-induced toxicity in PC12 cells J NEUROCHEM 89 (1): 134-141 APR 2004

GOOD SCIENCE WITHOUT A METHOD TO COMMERCIALIZE IT WILL NOT BENEFIT ANYONE

CANTERPENE AS AN ANTIAGING STRATEGY

The name of the game is to beat this clock

Lifespan Pharma Inc SW34-01-16-W2nd meridian Box 10 Beaubier, Sk., CANADA Lifespan.pharma.inc@gmail.com 701-240-9411

Presented at : Canadian Hemp Trade Alliance Nov 15-17, 2010 Annual Conference Winnipeg , Manitoba , Canada