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1. C .. (2000) ,
65, 112126.
2. Frenkel, G.D., Caffrey, P.B. (2001)
Curr. Pharm. Design, 7, 15951614.
3. Ojima, I., Bounaud, P.-Y., Oderda,
C.F. (1998) Exp. Opin. Ther. Patents,
8, 15871598.
4. Germann, U.A., Harding, M.W. (1995)
J. Natl. Cancer Inst., 87, 15731575.
5. ickley, L.A., Bates, S.E., Richert
N.D. (1989) J. Biol. Chem., 264,
1803118040.

6. Wright, J.J., Illum, L. (1992) Ed.


Donbrow M., CRC Press Boca Raton
London, 281297.
7. Couvreur, P., Kante, B., Lenaerts, V., et
al. (1980) J. Pharm. Sci., 69,199202.
8. Hanahan, D., Folkman, J. (1996) Cell,
86 (3), 353364.
9. Holtl, L., Rieser, C., Papesh, C., Ramoner, R., Herold, M., Klocker, H.,
Radmayr, C., Stenzl, A., Bartsch, G.,
Thurner, M. (1999) J. Urol., 161,
777782.

60
10. Steinman, R.M., Dhodapkar, M. (2001)
Int. J. Cancer, 94, 459473.
11. Reid, C.D.L. (2001) British J. Haematol, 112, 874887.
12. Geromin, D., Bourge, J.F., Soulie,
A., et al. (2004) J. Immunol., 172,
36043611.
13. Scheper, R.J., Dalton., W.S., Grogan,
T.M. (1991). Int. J. Cancer, 48, 562.
14. Shtil, A.A., Turner, J.G., Durfee, J.
(1999). Blood, 93, 18311837.
15. Hatano, T., Ohkawa, K., Matsuda, M.
(1993) Tumor Biol, 14, 288294.
16. Ohkawa, K., Hatano, T., Tsukada,
Y., et al. (1993) Br. J. Cancer, 67:
274278.
17. Ohkawa, K., Hatano, T., Yamada,
K., et al. (1993) Cancer Res. 53,
42384242.
18. Embleton, M.J. (1987) J. Cancer, 55,
227231.
19. Moro, R., Tamaoki, T., Wegmann,
T.G., et al. (1993).Tumor Biol. 14,
116130.
20. Severin, S.E., Kanevski, V.Y., Sologub,
V.K., et al. (1994). Abstracts of XXII
Meeting of the ISOBM, Groningen,
120.
21. .., ..,
.. . (2005) , 26, 2, 122125.
22. Severin, S.E., Moskaleva, E.Yu.,
Shmyrev, I.I., et al. (1995) Biochem.
Molec. Biol. Intern., 37, 385397.
23. Severin, S.E., Moskaleva, E.Yu., Posypanova, G.A (1996) Tumor arg.
2, 299306.
24. Moskaleva, E.Yu., Posypanova, G.A.,
Shmyrev, I.I., et al. (1997) Cell Biology International. 21(12). 793799.
25. .., .., .. . (1997)
, 6, 45 47.
26. .., .., .. . (1998) , , 2, 2025.

.., ..
27. .., .., .. . (1998) . 2, 1518.
28. ., .., .. . (1998) , 1, 2125.
29. ., .., .. . (1998) , . 1, 3437.
30. ., .., .. (1999) , . 1, 4044.
31. .., ., . . (1999) , . 1, 4448.
32. Lutsenko, S.V., Feldman, N.B., Finakova, G.V., et al. (1999) Tumor Biol.,
2, 218224.
33. . ., .., .. . (2000). .
65, 859864.
34. ., .., .. . (2000) , . 2, 1722.
35. .., .., .. . (2000) . 13, 2327
36. Lutsenko, S.V., Feldman, N.B., Finakova, G.V., et al. (2000) Tumor
Biol., 21, 367374.
37. Coppelli, F.M., Grandis, J.R. (2005)
Curr. Pharm. Design, 11, 28252840.
38. Cleave, M.E., Monia, B.P. (2005)
Nat. Rev., 5, 468479.
39. .., ..,
.. . (2002)
, ,
., 44(9), 900901.
40. Moghimi, S.M., Hunter, A.C., Murray,
J.C. (2005). FASEB J., 19, 311330.
41. Begley, D.J. (2004). Pharmacol.
Ther., 104, 2945.


42. Gulyaev, A.E., Gelperina, S.E., Skidan, I.N., Antropov, A.S., Kivman,
G.Y., Kreuter, J. (1999). Pharm. Res.,
16, 15641569.
43. Steiniger, S.C.J., Kreuter, J., Khalansky, A.S., Skidan, I.N., Bobruskin,
A.I., Smirnova, Z.S., Severin, S.E.,
Uhi, R., Kock, M., Geiger, K.D., Gelperina, S.E. (2004) Int. J. Cancer,
109, 159167.
44. Kreuter, J., Ramge, P., Petrov, V.,
Hamm, S., Gelperina, S.E., Engelhardt, B., Alyautdin, R., von Briesen,
H., Begley, D.J. (2003). Pharm. Res.,
20, 409416.
45. .., .., .., .. (2003). , 68 (5), 611631.
46. Nyberg, P., Xie, L., Kalluri, R. (2005)
Cancer Res., 65 (10), 39673979.
47. Folkman, J. (2003). Cancer Biol.
Ther., 2 (4, suppl. 1), S127S133.
48. Carmeliet, P., Jain, R.K. (2000).
Nature, 407, 249257.
49. Folkman, J. (2003). Curr. Mol. Med.,
3, 643651.
50. Colorado, P.C., Torre, A., Kamphaus,
G., Maeshima, Y., Hopfer, H., Takahashi, K., Volk, R., Zamborsky, E.D.,
Herman, S., Sarkar, P.K., Ericksen,
M.B., Dhanabal, M., Simons, M., Post,
M., Kufe, D.W., Weichselbaum, R.R.,
Sukhatme, V.P., Kalluri, R. (2000).
Cancer Res., 60 (9), 25202526.
51. O'Reilly, M.S., Holmgren, L., Shing,
Y., Chen, C., Rosenthal, R.A., Moses,
M., Lane, W.S., Cao, Y., Sage, E.H., Folkman, J. (1994). Cell, 79, 315328.
52. Eriksson, K., Magnusson, P., Dixelius,
J., Claesson-Welsh, L., Cross, M.J.
(2003). FEBS Lett., 536, 1924.
53. Sacco, M.G., Caniatti, M., Cato,
E.M., Frattini, A., Chiesa, G., Ceruti,
R., Adorni, F., Zecca, L., Scanziani,
E., Vezzoni, P. (2000). Cancer Res.,
60, 26602665.
54. O'Reilly, M.S., Boehm, T., Shing, Y.,
Fukai, N., Vasios, G., Lane, W.S.,

61

Flynn, E., Birkhead, J.R., Olsen,


B.R., Folkman, J. (1997). Cell, 88
(2), 277285.
55. Dhanabal, M., Volk, R., Ramchandran, R., Simons, M., Sukhatme, V.P.
(1999). Biochem. Biophys. Res. Commun., 258, 345352.
56. Ding, Y.H., Javaherian, K., Lo, K.M.,
Chopra, R., Boehm, T., Lanciotti, J.,
Harris, B.A., Li, Y., Shapiro, R., Hohenester, E., Timpl, R., Folkman, J.,
Wiley, D.C. (1998). Proc. Natl. Acad.
Sci. USA, 95 (18), 1044310448.
57. Hanai, J., Dhanabal, M., Karumanchi, S.A., Albanese, C., Waterman, M.,
Chan, B., Ramchandran, R., Pestell,
R., Sukhatme, V.P. (2002). J. Biol.
Chem., 277 (19), 1646416469.
58. Tjin Tham Sjin, R.M., Satchi-Fainaro, R., Birsner, A.E., Sadagopa, Ramanujam, V.M., Folkman, J., Javaherian, K. (2005). Cancer Res., 65
(9), 36563663.
59. O'Reilly, M.S., Boehm, T., Shing, Y.,
Fukai, N., Vasios, G., Lane, W.S.,
Flynn, E., Birkhead, J.R., Olsen,
B.R., Folkman, J. (1997). Cell, 88
(2), 277285.
60. Ma, C.-H., Zhang, Y., Wang, X.-Y., Gao,
L.-F., Liu, H., Guo, C., Liu, S.-X.,
Cao, Y.-L., Zhang Li-Ning, Sun, W.-S.
(2004). World J. Gastroenterol., 10
(19), 28742877.
61. Boehm, T., Folkman, J., Browder, T.,
O'Reilly, M.S. (1997). Nature, 390,
404407.
62. Nyberg, P., Heikkila, P., Sorsa, T.,
Luostarinen, J., Heljasvaara, R., Stenman, U.H., Pihlajaniemi, T., Salo,
T. (2003). J. Biol. Chem., 278 (25),
2240422411.
63. O'Reilly, M.S., Holmgren, L., Chen,
C., Folkman, J. (1996). Nat. Med., 2
(6), 689692.
64. Sidky, Y.A., Borden, E.C. (1987). Cancer Res., 47 (19), 51555161.
65. Byzova, T.V., Goldman, C.K., Pampori, N., Thomas, K.A., Bett, A., Shattil,

62
S.J., Plow, E.F. (2000). Mol. Cell, 6
(4), 851860.
66. Cozzolino, F., Torcia, M., Aldinucci,
D., Ziche, M., Almerigogna, F., Bani,
D., Stern, D.M. (1990). Proc. Natl.
Acad. Sci. USA, 87 (17), 64876491.
67. Mongiat, M., Sweeney, S.M., San Antonio, J.D., Fu, J., Iozzo, R.V. (2003).
J. Biol. Chem., 278, 42384249.
68. Chen, H., Herndon, M.E., Lawler, J.
(2000). Matrix Biol., 19, 597614.
69. Thomas, D.A., Kantarjian, H.M. (2000).
Curr. Opin. Oncol., 12, 564573.
70. Ziche, M., Donnini, S., Morbidelli,
L. (2004). Curr. Drug Targets, 5,
389406.
71. Albig, A.R., Schiemann, W.P. (2004).
DNA Cell. Biol., 23, 367379.
72. Maeshima, Y., Manfredi, M., Reimer,
C., Holthaus, K.A., Hopfer, H., Chandamuri, B.R., Kharbanda, S., Kalluri, R. (2001). J. Biol. Chem., 276,
1524015248.
73. Satchi-Fainaro, R., Puder, M., Davies, J.W., Tran, H.T., Sampson, D.A.,
Greene, A.K., Corfas, G., Folkman, J.
(2004). Nat. Med., 10 (3), 255261.
74. Yu, Y., Moulton, K.S., Khan, M.K.,
Vineberg, S., Boye, E., Davis, V.M.,
O'Donnell, P.E., Bischoff, J., Milstone, D.S. (2004). Proc. Natl. Acad.
Sci. USA, 101 (21), 80058010.
75. Singhal, S., Mehta, J., Desikan, R.,
Ayers, D., Roberson, P., Eddlemon, P.,
Munshi, N., Anaissie, E., Wilson, C.,
Dhodapkar, M., Zeddis, J., Barlogie,
B. (1999). N. Engl. J. Med., 341 (21),
15651571.
76. Bertolini, F., Mingrone, W., Alietti,
A., Ferrucci, P.F., Cocorocchio, E.,
Peccatori, F., Cinieri, S., Mancuso,
P., Corsini, C., Burlini, A., Zucca, E.,
Martinelli, G. (2001). Ann. Oncol.,
12 (7), 987990.
77. Iruela-Arispe, M.L., Luque, A., Lee,
N. (2004). Int. J. Biochem. Cell Biol.,
36, 10701078.

.., ..
78. Sudhakar, A., Sugimoto, H., Yang, C.,
Lively, J., Zeisberg, M., Kalluri, R.
(2003). Proc. Natl. Acad. Sci. USA,
100, 47664771.
79. D'Amato, R.J., Loughnan, M.S., Flynn,
E., Folkman, J. (1994). Proc. Natl.
Acad. Sci. USA, 91, 40824085.
80. Bertolini, F., Mingrone, W., Alietti,
A., Ferrucci, P.F., Cocorocchio, E.,
Peccatori, F., Cinieri, S., Mancuso,
P., Corsini, C., Burlini, A., Zucca, E.,
Martinelli, G. (2001). Ann. Oncol.,
12 (7), 987990.
81. Blagosklonny, M.V. (2001) Int. J.
Oncol., 19, 257262.
82. Soengas, M.S., Capodieci, P., Polsky,
D., et al. (2001) Nature, 409, 207211.
83. .., .E.
(2002) , 1, 816.
84. Severin, E.S., Moskaleva, E.Yu., Severin, S.E. (2001) Russian Journal of
Immunology, 6(4), 346356.
85. Hart, D.N.J. (1997) J. Amer. Society
of Hemat. 90(9), 32453287.
86. Steinman, R.M., Cohn, Z.A. (1973) J.
Exp. Med., 137, 11421162.
87. Massard, G., Tongio, M.M., Wihlm,
J.M., Morand, G. (1996) Ann. Thorac.
Surg. 61, 252258.
88. Peters, J.N., Gieseler, R., Thiele, B.,
Steinbach, F. (1996) Immunol. Today.
17(6), 273278.
89. Austyn, J.M., Phil, D. (1998) Curr.
Opin. Hematol. 5, 315.
90. Clark, G.J., Angel, N., Kato, M., Lopez, A., MacDonald, K., Vuckovic,
S., Harr, D.N.J. (2000). Microbes
infect., 2, 257272.
91. Coulie, P.G., Van den Eynde, B.J.,
van der Bruggen P, et al. (1997).
Biochemical Society Transactions,
25, 544548.
92. Lindauer, M., Stanislawski, Th., Hubler, A. et al (1998).J. Mol. Med. 76,
3247.
93. Nicola, M.D., Anichini, A., Mortarini,
R. et al (1998). Cell. Mol. Ther., 4,
265273.


94. Palucka, K.A, Taquet, N., Sanchez-Chapuis, F., Claude Gluckman, J. (1998)
J. Immunol., 160, 45874595.
95. Reid, C., Fryer, P., Clifford, C., et al.
(1990) Blood, 76, 11391149.
96. Rinderknecht, H. (1962). Nature, 193,
167.
97. Steinbach, F., Krause, D., Bl, B.,
et al. (1998). Res. Immunol., 149,
627632.
98. Stockwin, K.H., McGonagle, D.,
Mar tin, I.G., Blair, G.E. (2000).
Immunology and Cell Biology, 78,
91102.
99. .. .
(1999), c. 608.
100. Chaux, P., Moutet, M., Faivre, J.,
Martin, F. (1996). Lab. Invest., 74,
97583.
101. Sallusto, F., Cella, M., Danielli, C.,
Lanzavecchia, A. (1995) J. Exp.
Med., 182, 389400.
102. Gabrilovitch, D.I., Chen ,H.L. Girgis, K.R. et al (1996). Nat. Med., 2,
10961103.
103. Ishida, T., Oyama, T., Carbone,
D.P., Gabrilovich, D.I. (1998). J.
Immunol., 161, 48424851.
104. Menetrier-Caux, C., Montmain, G.,
Dieu, M.C. et al (1998). Blood, 92,
47784791.
105. Wittke, F., Hoffmann, R., Buer, J.,
et al. (1997).. Br. J. Cancer, 79,
11821184.
106. Caux, C., Dezutter-Dambuyant, C.,
Schmitt, D., et al. (1992) Nature,
360, 258261.
107. Caux, C., Massacrier, C., Vanbervliet, B., et al. (1997) Blood, 90,
14581470.
108. Caux, C., Vanbervliet, B., Massacrier, C., et al. (1996) J. Exp. Med.,
184, 695706.
109. Caux, C., Vanbervliet, B., Massacrier, C., et al. (1996) Blood, 87,
23762385.

63

110. Reid, C., Stackpoole, A., Meager,


A., et al. (1992) Biochem.Mol. Biol.
Intern., 37(2), 385397.
111. Santiago-Schwarz, F., Belilos, E.,
Diamond, B., et al. (1992) Journal
of Leukocyte Biology, 52, 274281.
112. Romani, N., Gruner, S., Bran, D.,
et al. (1994) J. Exp. Med., 180,
8393.
113. Romani, N., Reider, D., Heuer, M.,
et al. (1996) J. Immunol. Methods,
196, 137151.
114. Sallusto, F., Lanzavecchia, A. (1994)
J. Exp. Med., 179, 11091118.
115. Alters, S.E., Gadea, J.R., Sorich,
M. (1998). J. Immunother., 21(1),
1726.
116. Nair, S.K. et al (1998) Nature Biotechnol., 16, 364369.
117. Nair, S.K., et al. (1999) Int. J. Cancer, 82, 121124.
118. Salgaller, M.L, Lodge, P.A, Tjoa,
B.A., et al. (1998). (Abstract 1187).
Proc Am Assoc Cancer Res., 39.
119. Salgaller, M.L., Lodge, P.A., McLean,
J.G. et al (1998). The Prostate, 35,
144151.
120. Salgaller, M.L. (1997) J. Immunother., 20, 114.
121. Alijagic, S., Moller, P., Artuc, M.,
et al. (1995). Eur. J. Immunol., 25,
31003107.
122. Boczkowski, D., Nair, S., Snyder,
D., Gilboa, E. (1996). J. Exp. Med.,
184, 46572.
123. Mller, M.R., Brossart, P. (2002) Mod.
Asp. Immunobiol., 2, 141144.
124. Gong, J., Chen, D., Kashiwsda,
M., Kufe, D. (1997). Nature, 3,
558561.
125. Bhardwaj, N., Bender, A., Gonzalez,
N., et al. (1994). Clin. Invest., 94,
797807.
126. .., ..,
.. . (2003) , , 7(9), 1927.

64
127. .., ..,
.. . (2003) , ,. 7(9), 2834.
128. .., ..,
.. . (2004) ,. 25(6), 345350.
129. Castellino, F., Boucher, P.E., Eichelberg, K., et al. (2000) J. Exp. Med.,
191, 19571964.
130. Srivastava, P. (2002) Annu. Rev.
Immunol, 20, 395425.
131. Kuppner, M. C., Gastpar, R., Gelwer,
S., et al. (2001) Eur. J. Immunol, 31,
1602 1609.
132. Singh-Jasuja, H., Scherer, H.U.,
Hilf, N., et al. (2000) Eur. J. Immunol, 30, 22112215.
133. Somersan, S., Larsson, M., Fonteneau, J.F. (2001) J. Immunol., 167,
48444852.
134. .., ..,
.. . (2005) , 6(1),
5056.
135. .., ..,
..,
.., ..,
.., .. (2005)
II . .
,
, 2021 2005.
136. Nestle, F.O., Alijagic, S., Gilliet, M.,
Sun, Y., Grabbe, S., Dummer, R.,
Burg, G., Schadendorf, D. (1998)
Natur. Med., 4, 328332.
137. Ridgway, D. (2003) Cancer Invest.,
21(6), 873886.
138. Toungous, M., Libin, M., Bulte, F.,
Faild, L., Lehmann, F., Duriau, D.,
Laporte, M., Gangji, D., Bruyns,
C., Lambermont, M., Goldman, M.,
Velu, T. (2001). J. Leukoc. Biol., 69,
937943.
139. Fay, J., Palucka, K., Dhodapkar, M., et
al. (2000). Blood, 96, 807a (abstr).

.., ..
140. Lotze, M.T., Shurin, M., Esche, C.,
et al. (2000).Cancer J. Sci. Am.,
6(Suppl 1), S61S66.
141. Nestle, F.O. (2000). Oncogene,19,
66736679.
142. Ribas, A., Butterfield, L.H., Vu, H.T.,
et al. (2001).Proc. Am. Soc. Clin.
Oncol., 20, 268a (abstr).
143. Banchereau, J., Palucka, A.K.,
Dhodapkar, M., et al. (2001). Cancer Res., 61, 64516458.
144. Gajewski, T.F., Fallarino, F., Ashikari, A., et al. (2001). Cancer Res.,
3(Suppl 3), 895s901s.
145. Schuler-Thurner, B., Schultz, E.S.,
Berger, T.G., et al. (2002). Exp.
Med., 19, 12791288.
146. Bercovici, N., Massicard, S., Baron,
V., et al. (2002). Cancer Res., 43,
558559 (abstr.).
147. Fong, L., Hou, Y., Benike, C., et al.
(2001). Proc. Natl. Assoc. Sci., 98,
88098814.
148. Lacy, M.Q., Wettstein, P., Gertz,
M.A., et al. (2000). Blood, 96, 374a
(abstr.).
149. Lacy, M.Q., Wettstein, P., Gertz,
M.A., et al. (2002). Proc. Am. Soc.
Clin. Oncol., 21, 31a (abstr.).
150. Fong, L., Brockstedt, D., Benike,
C., et al. (2001). J. Immunol., 166,
42544259.
151. Fong, L., Brockstedt, D., Benike,
C., et al. (2001). J. Immunol., 167,
71507156.
152. Tjoa, B.A., Elgamal, A.A., Murphy,
G.P. (1999). Urol. Clin. North Am.,
26, 365374.
153. Shankar G., Kelley H., Lodge A., et
al. (2001). Proc. Am. Assoc. Cancer
Res., 42, 2627(abstr.).
154. Takaue, Y., Tanosaki, R., Tobisu, K.,
et al. (2002). Proc. Am. Soc. Clin.
Oncol., 21, 18b (abstr.).
155. Mansi, J.L., Pandha, H.S., John, J.,
et al. (2002). Proc. Am. Soc. Clin.
Oncol., 21, 17b (abstr.).

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