Академический Документы
Профессиональный Документы
Культура Документы
.-. ..
2013
() .
= .
(, )
() =
.
.
,
.
,
2-.
: (, ),
, ,
.
Kiss-peptin = (U.B.Kaiser, J Clin
Invest.2012;122(10):34673468).
()
(, , )
( )
health-7.com
-
.
,
-,
.
-
.
()
(jet leg)
(, )
(, ,)
( 100 /)
(+jet-leg, c,
, ).
!
,
, , .
, , .
()
.
,
.
L- .
40% .
25-34 .
30-50 100 000.
100.000
39% -
-
-- 14%
-- -7%
1/3
0.1-0.2% , .
Am J Obstet Gynecol 1972; 113:14; N Engl J Med 1977; 296:589; Clin Ther 200; 22:1085; Clin Endocrinol 1976; 5:273;
J Clin Endocrinol Metab 1976; 42:1148; J Clin Endocrinoll Metab 42: 181; J Clin Endocrinol Metab 1982; 54:869; Br Med J 1976; 1:1186;
JAMA 1976; 235:2316; Am J Cardiol 1983; 51:1466; J Clin Endocrinol Metab 1985; 60:144.
-
10
- 0-12.5%
,
-
10
50%
()
=
.
-
226
94/.
,
.
-
:
: , , , ,
25-100 /
,
(50-100% )
(2)
(!)
,
-
- 3-5
, ,
200/
8-9%,
.
30%
, .
()
()
! .
,
. !
( )
- : ,
.
,
( )
(?) ( , )
, , ,
, ( ).
( (?), , )
, 6
10 %
.
30%
.
(Elms AF 2012),
(R. W. Turkington 1971), -
.
! .
()
1/3
/
.
.
( , ,
, , (?),
).
, (?),
.
, ,
(.. ).
-
( 25%),
!
.
-
b-
, ,
.
( 2013),
.
( ).
.
25/
1/=21,2/
, ( ).
S. Melmed et al J Clin Endocrinol Metab, February 2011, 96(2):273288 Diagnosis and Treatment of Hyperprolactinemia: Endocr Society Clinical Practice Guideline
:
( ).
big-big-
.
big-big-
, .
, 40% .
20%, /- 45%,
20%.
S. Melmed et al J Clin Endocrinol Metab, February 2011, 96(2):273288 Diagnosis and Treatment of Hyperprolactinemia: Endocr Society Clinical Practice Guideline
:hook-effect
: ,
-
= .
.
S. Melmed et al J Clin Endocrinol Metab, February 2011, 96(2):273288 Diagnosis and Treatment of Hyperprolactinemia: Endocr Society Clinical Practice Guideline
500/
250/ ( 10 )
200/
S. Melmed et al J Clin Endocrinol Metab, February 2011, 96(2):273288 Diagnosis and Treatment of Hyperprolactinemia: Endocr Society Clinical Practice Guideline
, :
( ,
)
,
.
S. Melmed et al J Clin Endocrinol Metab, February 2011, 96(2):273288 Diagnosis and Treatment of Hyperprolactinemia: Endocr Society Clinical Practice Guideline
, .
:
-
- , 4
- , /
- , , ,
- 1
( , ,
, )!!!
S. Melmed et al J Clin Endocrinol Metab, February 2011, 96(2):273288 Diagnosis and Treatment of Hyperprolactinemia: Endocr Society Clinical Practice Guideline
:
( )
(), - +
, +
.
();
.
(
L-).
() .
-
( ).
, , ,
.
,
.
.
2 5
( ) - 67% (Colao A, N. Engl. J. Med.
2003).
, .
.
S. Melmed et al J Clin Endocrinol Metab, February 2011, 96(2):273288 Diagnosis and Treatment of Hyperprolactinemia: Endocr Society Clinical Practice Guideline
0,5 1 2 ( 0,5
) ( ).
0,5
. ,
1 / 0,25 2 /.
4,5 /.
2
.
>1 /.
, ,
(1 ) .
, , 24
.
( 0,25 1 )
.
( 0,25 2 )
.
1 .
1 , 1 .
,
( , ) 3 .
.
,
, .
S. Melmed et al J Clin Endocrinol Metab, February 2011, 96(2):273288 Diagnosis and Treatment of Hyperprolactinemia: Endocr Society Clinical Practice Guideline
2
.
=26-69%
Biswas M, 2005.Clin Endocrinol (Oxf) 63:2631 ;Kharlip J 2009 J Clin Endocrinol Metab 94:24282436
.
28%
- 3
, .
- - .
S. Melmed et al J Clin Endocrinol Metab, February 2011, 96(2):273288 Diagnosis and Treatment of Hyperprolactinemia: Endocr Society Clinical Practice Guideline
/
.
( , -
).
.
,
75% ,
.
.
S. Melmed et al J Clin Endocrinol Metab, February 2011, 96(2):273288 Diagnosis and Treatment of Hyperprolactinemia: Endocr Society Clinical Practice Guideline
, . !
.
, ,
.
S. Melmed et al J Clin Endocrinol Metab, February 2011, 96(2):273288 Diagnosis and Treatment of Hyperprolactinemia: Endocr Society Clinical Practice Guideline
10%
25%, 80%
S. Melmed et al J Clin Endocrinol Metab, February 2011, 96(2):273288 Diagnosis and Treatment of Hyperprolactinemia: Endocr Society Clinical Practice Guideline
(50%)
.
-
.
- 2 ?
(18%
), 10%.
.
11/.
( )!
S. Melmed et al J Clin Endocrinol Metab, February 2011, 96(2):273288 Diagnosis and Treatment of Hyperprolactinemia: Endocr Society Clinical Practice Guideline
7 50%
.
, ,
, .
( 50 )
, .
S. Melmed et al J Clin Endocrinol Metab, February 2011, 96(2):273288 Diagnosis and Treatment of Hyperprolactinemia: Endocr Society Clinical Practice Guideline
.
6000
(1).
80 ( 5 ) -
(2).
-
.
, ..
.
1 ( ).
S. Melmed et al J Clin Endocrinol Metab, February 2011, 96(2):273288 Diagnosis and Treatment of Hyperprolactinemia: Endocr Society Clinical Practice Guideline
(
).
.
457 , ,
2,6% (1).
4,5-5% (1).
(31%) (1). .
.
,
, - .
100
,
.
- .
S. Melmed et al J Clin Endocrinol Metab, February 2011, 96(2):273288 Diagnosis and Treatment of Hyperprolactinemia: Endocr Society Clinical Practice Guideline
!
.
,
! .
S. Melmed et al J Clin Endocrinol Metab, February 2011, 96(2):273288 Diagnosis and Treatment of Hyperprolactinemia: Endocr Society Clinical Practice Guideline
10
:
: 19972008, 143 91
( 30.4 4.7 , 76 , 10 ).
6 ..
: 13 (9.1%) , 126 (88.1%) .
. 29 91 (3 ),
6 -
, 68% 60
. . 35 (38.5%)
2 , 56 (61.5%) 2 6 .
% .
:
.
68%.
.
:
(, )
.
,
,
.
().
.
( ) .
.
,
,
.
.
C !