http://ru.wikipedia.

org/wiki/_

(//ru.wikipedia.org/w/index.php?title=%D0%A1
%D0%B8%D0%BD%D1%82%D0%B5%D1%82%D0%B8%D1%87%D0%B5%D1%81
%D0%BA%D0%B8%D0%B5_%D0%BA%D0%B0%D0%BD%D0%BD%D0%B0%D0%B1
%D0%B8%D0%BD%D0%BE%D0%B8%D0%B4%D1%8B&stable=1) , 30
2010; 2 (//ru.wikipedia.org/w/index.php?title=
%D0%A1%D0%B8%D0%BD%D1%82%D0%B5%D1%82%D0%B8%D1%87%D0%B5
%D1%81%D0%BA%D0%B8%D0%B5_%D0%BA%D0%B0%D0%BD%D0%BD%D0%B0
%D0%B1%D0%B8%D0%BD%D0%BE%D0%B8%D0%B4%D1%8B&oldid=29526680&
diff=cur&diffonly=0) .

,
CB1 CB2.

1
2
2.1
2.2
2.3
2.4
2.5
2.6
2.7

()
3

HU-210 -

1960-
JWH-018,
.
-.
( CP)

Pfizer 1970- 1980- .
( JWH)
(. John W. Huffman)
1995 .

1 de 9

31/12/11 01:18

http://ru.wikipedia.org/wiki/_

7 .
(1-7) Ki
CB1.
, . , Ki
9- () 10,2 , JWH-387 - 43
. , 1- JWH-387
4 . Ki 100,
. ,
,
, 4 (JWH-194, JWH-195, JWH-196, JWH-197),
7 (JWH-116, JWH-200, JWH-175,
JWH-176, JWH-184, JWH-192, JWH-199), .
, .
,

30.10.2010 . 882
,
.
" " [1],
"

,
(, , , )
(, , -, -, -, -, -,
-, -, -, -, -,
)".

2 de 9

R1

R2

R3

R4

Ki()

JWH-004

Hexyl Methyl H

48

JWH-007

Pentyl Methyl H

2.9

JWH-009

Heptyl Methyl H

1000+

JWH-015

Propyl Methyl H

165

JWH-016

Butyl

22

JWH-018

Pentyl H

2.9

JWH-019

Hexyl H

9.8

JWH-020

Heptyl H

128

Methyl H

31/12/11 01:18

JWH-046

R1
R2
R3
Propyl Methyl H

R4 Ki()
Methyl 343

JWH-047

Butyl

Methyl 59

JWH-048

Pentyl Methyl H

Methyl 0.158

JWH-049

Hexyl Methyl H

Methyl 55

JWH-050

Heptyl Methyl H

Methyl 342

JWH-070

Methyl H

1000+

JWH-071

Ethyl

1000+

JWH-072

Propyl H

1000+

JWH-073

Butyl

8.9

JWH-076

Propyl H

Methyl 214

JWH-079

Propyl H

Methoxy H

JWH-080

Butyl

Methoxy H

7.6

JWH-081

Pentyl H

Methoxy H

1.2

JWH-082

Hexyl H

Methoxy H

5.3

JWH-094

Propyl H

Methoxy H

476

JWH-096

Butyl

Methoxy H

34

JWH-098

Pentyl Methyl Methoxy H

4.5

JWH-116

Pentyl Ethyl

52

JWH-120

Propyl H

Methyl

1000+

JWH-122

Pentyl H

Methyl

0.69

JWH-148

Propyl Methyl Methyl

213

JWH-149

Pentyl Methyl Methyl

JWH-164

____

____

____

6.6

JWH-180

Propyl H

Propyl

26

JWH-181

Pentyl Methyl Propyl

1.3

JWH-182

Pentyl H

Propyl

0.65

JWH-189

Propyl Methyl Propyl

52

JWH-193

MPE

Methyl

JWH-198

MPE

Methoxy H

10

JWH-200

MPE

42

JWH-210

Pentyl H

Ethyl

0.46

JWH-211

Propyl Methyl Methyl

70

JWH-212

Propyl H

Ethyl

33

JWH-213

Pentyl Methyl Ethyl

1.5

JWH-234

Pentyl H

Ethyl

8.4

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http://ru.wikipedia.org/wiki/_

Methyl H

____

63

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http://ru.wikipedia.org/wiki/_

JWH-235

R1
R2
Propyl H

R4
Ethyl

JWH-236

Propyl Methyl H

Ethyl

1000+

JWH-239

Propyl H

Butyl

342

JWH-240

Pentyl H

Butyl

14

JWH-241

Propyl Methyl Butyl

147

JWH-242

Pentyl Methyl Butyl

42

JWH-262

Pentyl Methyl H

Ethyl

28

JWH-386

Propyl H

Br

161

JWH-387

Pentyl H

Br

43

JWH-394

Pentyl Methyl Br

2.8

JWH-395

Propyl Methyl Br

372

JWH-397

Pentyl Methyl Cl

8.9

JWH-398

Pentyl H

Cl

2.3

JWH-399

Propyl Methyl Cl

187

JWH-400

Propyl H

Cl

93

JWH-412

Pentyl H

7.2

JWH-413

Pentyl Methyl F

14

JWH-414

Propyl H

240

JWH-415

Propyl Methyl F

530

R3

Ki()
338

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R1

http://ru.wikipedia.org/wiki/_

R2

R3

Ki()

JWH-175

Pentyl H

22

JWH-184

Pentyl H

Methyl

23

JWH-185

Pentyl H

Methoxy 17

JWH-192

MPE

Methyl

JWH-194

Pentyl Methyl Methyl

127

JWH-195

MPE

113

JWH-196

Pentyl Methyl H

151

JWH-197

Pentyl Methyl Methoxy 323

JWH-199

MPE

H
H

41

Methoxy 20

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R1

R2

Ki()

JWH-030

Pentyl H

87

JWH-145

Pentyl Phenyl

14

JWH-146

Heptyl Phenyl

21

JWH-147

Hexyl Phenyl

11

JWH-150

Butyl

60

JWH-156

Propyl Phenyl

404

JWH-243

Pentyl 4-Methoxyphenyl

285

JWH-244

Pentyl 4-Methylphenyl

130

JWH-245

Pentyl 4-Chlorophenyl

276

JWH-246

Pentyl 3-Chlorophenyl

70

JWH-292

Pentyl 2-Methoxyphenyl

29

JWH-293

Pentyl 3-Nitrophenyl

100

JWH-307

Pentyl 2-Fluorophenyl

7.7

JWH-308

Pentyl 4-Fluorophenyl

41

JWH-346

Pentyl 3-Methylphenyl

67

JWH-348

Pentyl 4-Trifluoromethylphenyl 218

JWH-363

Pentyl 3-Trifluoromethylphenyl 245

JWH-364

Pentyl 4-Ethylphenyl

34

JWH-365

Pentyl 2-Ethylphenyl

17

JWH-367

Pentyl 3-Methoxyphenyl

53

JWH-368

Pentyl 3-Fluorophenyl

16

Phenyl

31/12/11 01:18

http://ru.wikipedia.org/wiki/_

JWH-369

R1
R2
Pentyl 2-Chlorophenyl

7.9

JWH-370

Pentyl 2-Methylphenyl

5.6

JWH-371

Pentyl 4-Butylphenyl

42

JWH-373

Pentyl 2-Butylphenyl

60

JWH-392

Pentyl 2-Trifluoromethylphenyl 77

Ki()

R1

JWH-176

R2

Pentyl H

Ki()
26

#7 MPE

2.7

#8 MPE

Methyl 2.9

R1

6 de 9

R2

Ki()

JWH-167

Phenyl

JWH-201

4-Methoxyphenyl 1000+

JWH-202

Methyl 4-Methoxyphenyl 1000+

JWH-203

JWH-204

Methyl 2-Chlorophenyl

13

JWH-205

Methyl Phenyl

124

JWH-206

389

JWH-207

Methyl 4-Chlorophenyl

1000+

JWH-208

4-Methylphenyl

179

JWH-209

Methyl 4-Methylphenyl

746

JWH-237

3-Chlorophenyl

38

JWH-248

4-Bromophenyl

1000+

JWH-249

2-Bromophenyl

8.4

JWH-250

2-Methoxyphenyl 11

JWH-251

2-Methylphenyl

29

JWH-252

Methyl 2-Methylphenyl

23

JWH-253

Methyl 3-Methoxyphenyl 62

2-Chlorophenyl

4-Chlorophenyl

64

31/12/11 01:18

R1

http://ru.wikipedia.org/wiki/_

Ki()
R2
3-Methoxyphenyl 17

JWH-302

JWH-303

Methyl 3-Chlorophenyl

117

JWH-304

Methyl 4-Bromophenyl

1000+

JWH-305

Methyl 2-Bromophenyl

15

JWH-306

Methyl 2-Methoxyphenyl 25

JWH-311

2-Fluorophenyl

23

JWH-312

3-Fluorophenyl

72

JWH-313

4-Fluorophenyl

422

JWH-314

Methyl 2-Fluorophenyl

39

JWH-315

Methyl 3-Fluorophenyl

430

JWH-316

Methyl 4-Fluorophenyl

1000+

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R1

R2

Ki()

CP-55,940 1,1-Dimethylheptyl

Hydroxypropyl 0.35

CP 47,497 1,1-Dimethylheptyl

9.54

VII 1,1-Dimethyloctyl

4.7

1,1-Dimethylhexyl

126

VIII 1,1-Dimethylnonyl

28.5

1,1-Dimethylethyl

1000+

II

1,1-Dimethylpropyl

1000+

III

1,1-Dimethylbutyl

1000+

IV

1,1-Dimethylpentyl

735

IX

1,1-Dimethyldecyl

163

31/12/11 01:18

http://ru.wikipedia.org/wiki/_

R1
1,1-Dimethylundecyl H

XI

1,1-Dimethylheptyl

Methyl

6.2

XII 1,1-Dimethylheptyl

Methyl

7.7

XIII H

Hydroxypropyl 1000+

XV 1,1-Dimethylheptyl

Hydroxypropyl 62

XVI 1,1-Dimethylheptyl

Hydroxybutyl

R2

Ki()
381

1.6

()

R1

R2

Ki()

9-THC

Pentyl

Methyl

10.2

8-THC

Pentyl

Methyl

16.5

Nabilone

1,1-Dimethylheptyl

Keto (=O)

1.84

HU-210

1,1-Dimethylheptyl

Hydroxymethyl 0.06

HU-211

1,1-Dimethylheptyl

Hydroxymethyl 100+

1,1-Cyclopropylheptyl

Methyl

0.44

1,1-Dimethylcyclohexyl Methyl

1,2-Dimethylheptyl

Methyl

1-

1,1-Dimethylheptyl

Methyl

1-

ACMD report on the major cannabinoid agonists (http://tonydagostino.co.uk

/tony_dagostin_1./Articles_&_Reports_files/acmd-report-agonists.pdf)

(http://huffman.chelcool.com
8 de 9

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http://ru.wikipedia.org/wiki/_

/media/metod_podhodi.pdf)
1.
(http://huffman.chelcool.com/media/proizvodnie.pdf)

http://ru.wikipedia.org/w/index.php?title=%D0%A1%D0%B8%D0%BD
%D1%82%D0%B5%D1%82%D0%B8%D1%87%D0%B5%D1%81%D0%BA%D0%B8
%D0%B5_%D0%BA%D0%B0%D0%BD%D0%BD%D0%B0%D0%B1%D0%B8%D0%BD
%D0%BE%D0%B8%D0%B4%D1%8B&oldid=36599113
: 11:39, 3 2011.
Creative Commons Attribution-ShareAlike;
. .
.
Wikipedia Wikimedia Foundation, Inc.,
.

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