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namo2eHe3a, iJuawocmuKu u !letteHUR: PyKoeoocmeo O!lR epatteu. M: 2002. - 328 c.
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2uHernJ102uu II PoccuiicKULt MeOUtJUHCJ..:uu JK:YPHa!l. - 2014. -Ml. - C. 42-47.
7. HU{-eHKO A.H. , EomeuH MA. , JlaH'lllHCk'UU B.H. PenpooyKmueHble npo6.T1eMb1 onepupoeaHHOu
MamKu. - M: MwUlout, 2007. - C. 16-22.
8. KapUMoe 3./(. c coaem. K01-1cepeamueHGR .M uo,,~3KmOMUR e npo6J1eMe eoccmaHoefleHUR
<fJepmU!lbHocmu y MO!lOOblX JK:eHUf-UH II JKypHa!l aKyutepcmea u JK:eHCKUX 6o!le3Heu. - 2011. - M4. - C.
147-150.
9. KpacHono!lbCKUU B.H., CuttuHaea JI.I'. , KaJ1y2uHa <t>.C. PenpooyKmueHble npo6J1eMb1
onepupoeaHHOu MamKu. - M: MwUlout, 2005. - 162 c.
JO. Ky!laKoe B.H. , lllMaKoe I'.C. MuoM3KmOMUR u 6epeMeHHOCmb. - M : MEJ(npecc-uH<jJopM,
2001. - 342 c.
11. JluHiJe B.A., J{o6poeo!lbCKuu HC. , c coaem. MuoMa MamKu u MUOM3KmoMUR. - M: MHA,
2010. -C. 122-126.
12. PbzMauwecKuu A.H. c coaem. Po!lb !letloMUOMbl MamKu e eo3HUKHOBeHuu 6ec11.!loiJuR II
BecmHUK poccuucK020 yHueepcumema iJpyJ1C6b1 Hapoooe. - 2012. - M3. - C. 15-17.
13. Cuoopoea H.C. MuoMa MamKu. -M: MHA , 2003. -C. 27-32.
14. CaeutJKUU I'.A ., Caeu4Kuu A.I'. MuoMa MamKu. «3JlCElf-CilE». - 2003. - C. 152-159.
15. TuxoMupoe A.JI., Jly6HUH J(M MuoMa Mam Ku. - M: MlfA , 2006. - C. 106-115.
16. Cobellis L., Pecori E. , Cobellis G. Hemostatik technigue for myomectory during cesarean
section II Int. J Gynaecol. Obstet. - 2002. - Vol. 79. - P. 261.
17. Cooper NP., Okolo S. Fibroids in pregnancy - common but poorly understood. Obstet.
Gynecol. Surv. - 2005. - Vol. 60. - P. 132.
18. Donnez J , Jadoul P. What are the implications of myomas on fertility? A need for a debate?
Human Reprod. 2002. - 17: 6: P. 1424-1430.
19. Ehigiegba A.E., Ande A.B. , Ojobo SI. Myomectomy during cesarean section. Int. J Gynaecol.
Obstet. - 2001. - Vol. 75. -P. 21.
20. Hanafi MMD. Predictors ofleiomyoma recurrence after myomectomy. Obstet. Gynec. 2005.
- 105: P. 877-881.
21. Jabiry-Zieniewicz Z,, Gajewska M The pregnancy and delivery course with pregnant women
with uterine myomas. Ginekol. Pol. - 2002. - Vol. 7. - P. 46-50.
22. Lethaby A., Voolenhoven B. Fibroids (uterine myomatosis, leiomyomas). Clin. Evid. 2004;
2406. - P. 26.
23. Somigliana E. , Vercellini P., Daguatil R. et al. Fibroids and female reproduction: a critical
analysis of the evidence. Human Reprod. Update 2007. - 13: 5: P. 465-476.

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51
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U306ymUJ1aMMOHUUOUH ea2UHaJl0blK 3pUmMecu.

EVALUATION OF VAGINAL IBUPROFEN IZOBUTANOLAMMONIY A

SOLUTION IN THE TREATMENT OF VAGINITIS
Samigullina A.E., Maksutova E.M., Sarybaeva K.A.
National Center of Maternity and Childhood Care,
Bishkek, Kyrgyz Republic.

Resume: the randomized controlled clinical trial for evaluation of efficacy of vaginal solution of
ibuprofen isobutanolammonium in vaginitis was conducted in National Center for Care of Maternity and
Children Health. Advantages in clinical features in patients treated with experimental regimen have been
shown after 2nd day of therapy, as well as reducing of complaints of vaginal pain (5.1-fold, p< 0. 001),
itch (by 80%, p<0.001), burning (by 40%, p<0.001) and vaginal discharges (by 40%, p<O.OOl)and also
was reported improvement of vaginitis clinical pattern. Trial results demonstrated effectiveness of
ibuprofen isobutanolammonium vaginal solution for treatment of vaginitis and confirmed its significance
as valuable and perspective agent for early and reliable control of vaginal symptoms.
Key words: vaginitis, symptom severity, ibuprofen isobutanolammonium vaginal solution.

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52
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BllURHue HQ co4ua!lbHy10 2,5±2,2 1,8±2,0 >0,05
QKmU6HOCmb (n11:arra30H: 0-7) (nHaITa30H: 0-8)

ITpH 3TOM BbUIBJieHo, qTo 6oJihIIIe scero rraa;HeHTKH )l(aJIOBaJIHCb Ha sarHHaJibHbIM 3Y.LJ:
(60%), BarnHaJibHOe )l()l(eHHe (79%) H BarnHaJibHble Bbl,[(eJieHIDI (100%). OcTaJibHbie CHMITTOMbl
oTMeqaJIHCb He 6oJiee, qeM y 1/3 )l(eHia;HH: 3TO - BarHHaJibHllil 60Jib (23%), BJIIDIHHe BarHHHTa
Ha ITOJIOBOM aKT (33%), BJIIDIHHe Ha crropTHBttyIO aKTHBHOCTb (30%) H BJIH51HHe Ha COll;HaJibttyIO
aKTHBHOCTb (28%). lfcxo,[(Hbie xapaKTepHCTHKH o6'beKTHBHOM oa;eHKH rrpH3HaKOB BarHHHTa
Jieqaia;HM BpaqoM y rraa;HeHTOK rrpencTaBJieHbl B Ta6JI. 2, KaK BH,[(HO H3 Ta6JIHll;bl o6e rpyrrrrhI
COITOCTaBHMbl H He HMeIOT ,[(OCTOBepHbIX pa3JIHqH:M, p>0,05.
B xone o6cJienosaHHH yCTaHOBJieHo, qTo 6oJihIIIe scero cpen11: rraa;HeHTOK BhUIBAAJIHCb
rroKpacHeHHe CJIH3HCTOM BJiararr11:ma (98%) H rnrrepeMIDI KO)l(H BYJihBapHoH: o6JiaCTH (67%). B
MeHbIIIeH: CTerreHH Ha6JIIO,[(aJIHCb JieMKOKCaHTOpe51 ( 41 % ) H B 3HaqH:TeJibHO MeHbIIIeH: Mepe -
ne3ITHTeJIH3aa;H51 CJIH3HCTOM BJiaraJIHia;a (2%).

TQ6JlUljQ 2 - HcxooHbte XQPQKmepucmuKu naifueHmoK: cpeoHue noKa3Qme!lu o6beKmueHou

OifeHKU.
[JQTJaMemTJbl no zvvnnaM KoHmTJO!lb 3Kcne/)UMeHm (P)
B03pacT, JieT 36,8±10,7 32,7±6,4 >0,05
(nHaITa30H: 18-55) (nHaITa30H: 23-47)
04eHKQ IloKpacHeHue 2,8±0,5 2,8±0,4 >0,05
CUMnmOM06, c!lu3ucmou (nHaITa30H: 1-3) (nHaITa30H: 2-3)
6a!l!lbl no lllOII I'unepeMUR KOJICU 1,6±0,8 1,9±0,9 >0,05
(nHaITa30H: 0-3) (nHaITa30H: 0-3)
JIeUKOKCQHmopeR 1,6±1,0 1,2±1,0 >0,05
(nHaITa30H: 0-3) (nHaITa30H: 0-3)
J(e:Jnume!lU3aifUR 0,2±0,2 0,1±0,3 >0,05
CJlU3UCmou (nHaITa30H: 0-2) (nHaITa30H: 0-1)

,ZJ;arree HaMH rrposeneHa oa;eHKa pe3yJihTaToB JieqeHHH Ha 3-H: neHb c MOMeHTa Haqarra
TeparrHH (rrepBbie pe3yJibTaTbl) H Ha 2-H: neHb IlOCJie OKOHqaHIDI eypca JieqeHH51
( OKOHqaTeJibHbie pe3yJibTaTbl).
B pe3yJihTaTe rrposeneHHoro HccJienosaHIDI ycrnHOBJieHo, qTo (rn6JI. 3) rrpH
cy6neKTHBHOM oa;eHKe (no IIIKaJie BAlll) rraa;HeHTaMH CHMITTOMOB BarHHHTa Ha 3-H: neHb
54
-
rreqeHHH OTMeqarroch CTaTHCTttqeCKH 3HaqJIMOe nocTOBepHoe y.rryqIIIeHHe CHMilTOMaTHKH no
cpaBHemno c HaqarroM rreqeHIDI B o6eHX rpyrrrrax no BceM rrapaMeTpaM, KpoMe BarHHaJibHOii
6orrH B rpyrrrre KOHTpOJIH, p=0,19. Oco6o 3Ha'IHMoe y.rry~eHHe Ha6monarroch B o6ettx rpyrrrrax
B yMeHbIIIeHHH )Ka.JI06 Ha BbmerreHIDI H3 IIOJIOBbIX rryTeH:, p<0,01.

Ta6Jlulfa 3 - Cy6MKmueHM OlfeHKa Ha 3-u iJeHb Jle1.JeHUR (2-u 6U3um) e cpaeHeHuu c

ucxoiJHblMU noKa3arnellJLMU {1-u eu3um).
IlapaMempbl KoHmpoll b 3KcnepUMeHm
M±rn YllYl.JUleHue P* M±m YllYl.JUleHue P*
BazuHaJlbHaR 6ollb 1,3±0,6 0,3 0,19 0,8±0,8 1,5 <0,01
BazuHaJlbHblU 3yiJ 2,0±1,4 1,7 <0,01 1,0±1,0 3,1 <0,01
BazuHaJlbHOe J1C:>1CeHue 2,6±1,3 2,9 <0,01 1,3±1, 1 3,9 <0,01
BazuHaJlbHble 3,6±1,0 4 ,4 <0,01 1,8±1,4 6,4 <0,01
6blOeJleHUJI,
Bll wmue Ha cnop- 1,4±0,9 1, 1 0,01 0,8±1,0 0,8 <0,05
mU6HY10 aKmU6HOCrnb
B.rzuRHue Ha co- 1,4±0,8 1,1 0,01 0,8±1,0 1,0 0,01
lfUaJlbHYIO aKmU6HOCmb
P* - cpaerteHue c ucxoOHblMU oaHHblMU (eU3um M2 c eU3umoM Ml) .

Crre~IOJnHM narroM ttccrrenoBaHIDI rrpoBeneHa cpaBHHTeJibHaH ou;eHKa 3<P<PeKTHBHOCTH

rreqeHHH Me)K~ rpynrraMH . .[(aHHbie rrpencTaBJieHHbie Ha pHC. 1 CBHneTeJibCTBYIOT 0 TOM, qTo B
rpyrrrre 3KCrrepHMeHTa y)Ke Ha 3-H: neHb rreqeHIDI rrpH cyfo,eKTHBHOH ou;eHKe CBOero COCTOHHHH
rrau;tteHTKaMH oTMeqarroch rrpeBocxoncTBo 3KcrrepHMeHTaJibHoro pe)KHMa Han KOHTporrhHhIM. B
3KCrrepHMeHTaJibHOH rpyrrrre CTaTHCTHqeCKH 3HaqHMO rrpeBocxonHJIH aHarrorHqHbie IlOKa3aTeJIH
KOHTpOJibHOH rpyrrrrhI: BarnHaJibHaH 6oJib - B 5,1 pa3a (P<0,001), BarnHaJibHbIB 3yn - Ha 80%
(P<0,001), BarnHaJibHOe )K)KeHHe - Ha 40% (P<0,001) H BarnHaJibHbie BbinerreHIDI - Ha 40%
(P<0,001).

• KOHTPOflb, yny4weHHO
• P<0.001
·. 3KCnEPlllMEHT. Y"Y"WOH"'O

Puc. 1. Cy6beKrnueHM OlfeHKa Ha 3-u iJeHb Jle1.JeHuR (2-u eU3um) e cpaeHeHuu c ucxoOHblMU
noKa3arneJlJLMU (1-u eu3urn).

lfa Ta6rr. 4 HarmnHo BHnHo, qro B xone 3KcrrepHMeHTa 6hrna noKa3aHa 6orree BhICOKaH
'.)<P<PeKTHBHOCTb rreqeHHH BarHHHTa rrpH no6aBJieHHH K CTaHnapTHOMY rrpoTHBOMHKpo6HOMY
pe)KHMy pacrnopa BarHHaJihHOro tt6yrrpo<PeHa mo6yTHJiaMMOHHH. CornacHo rro.rryqeHHhIM
naHHbIM, BarHHaJibHbIB paCTBOp, rrpHMeHHeMbIB B rpyrrrre 3KCrrepHMeHTa CTaTHCTHqecKH H
KJIHHHqecKH nocTOBepHO ycKOpHeT Hcqe3HOBeHHe TaKHx CHMilTOMOB, KaK BarHHa.JlbHbIH 3yn B
9,6 pa3 6bICTpee KOHTpOJibHOH rpyrrllbI, BarHHaJibHaH 60Jib rrepecTaeT 6ecrroKOHTb B 7,8 pa3
qaine, BarHHaJibHOe )K:>KeHHe Hcqe3aeT B 5,6 pa3 6hICTpee, B 4,9 pa3 6bICTpee BarHHHT rrepecTaeT
MeIIIaTb crropTHBHOH aKTHBHOCTH :>KeHrrnrn. I1pH 3TOM, IlOKa3aTeJIH CHMilTOMaTHKH B rpyrrrre

55
3KCnepI1MeHTa CHmI<aJIIICh B pa3hI (B 3-10 pa.3), a B rpynne KOHTpOml - He 6onee, qeM Ha 50%
no nOKa.3aTemIM BarIIHaJihHOH 60.TIII II BarIIHaJihHOro 3y.na II B 3,4 pa.3a - no nOKa.3aTemo
BJIIDIHIDI Ha CO:UilaJihHYIO aKTIIBHOCTh.
TaKHM o6pa.30M, HayqHo .JJ.OKa.3aHa poJih pacrnopa aarnHaJihHoro I16ynpo<iieHa
mo6yTI1JiaMMOHm1 B )J.OCTil)l(eHIIII BhICOKOH 3<li<lieKTIIBHOCTII KJIIIHHqeCKOH TepanIIII aarIIHIITa y
nauI1eHTOK 3KCnepI1MeHTaJihHOH rpynnhI B cpaBHeHIIII c KOHTpOJihHOH y)l(e K TpeTbeMy )J.HIO
JieqeHIIH, npII 3TOM BarIIHaJihHhIB paCTBOp )J.OCTOBepHO nyqme 06ecneqI1aaeT Ha)J.e)l(HhIH
KOHTpOJih B OTHOIIIeHIIII 60.TihIIIIIHCTBa 6ecnoKOHIIJ;HX nauileHTKY CIIMnTOMOB, p<0,001.

TQ6JlUlfQ 4 -IfcIJe3HOBeHue cUMnmoMoe e 2pynnax no cpQBHeHu10 c HQIJQJlOM ucc!leiJoeQHUJI.

(BAlll).
[/QpaMempbl KoHmTJOllb 3KcnepUMeHm
BQZUHaJlbHaJI. 6o!lb Ha49% j B 7,8 pa.3 j
BQZUHaJlbHblU 3yiJ Ha47%j B 9,6 pa.3 j
BQZUHaJlbHoe :>1c:J1ceHue Ha 32%t B 5,6 Pa.3 t
BQZUHaJlbHble eb10e!leHUJ1. - B2,7pa.3 j
BllUJl.Hue HQ cnopmueHy10 QKmueHocmb - B 4,9 pa.3 j
BllUJl.HUe HQ COlfUaJlbHY10 QKmueHoCmb B 3,4 pa.3 t B 2,9 pa.3 t

AHaJIIl3IIPYH pe3yJihTaThI (rn6n. 5) o6'heKTIIBHoli oueHKII no IIIKaJie lllOil cne.nyeT

OTMeTIITh, qTo Ha 3-li .neHh neqeHIIH OTMeqaeTCH )J.OCTOBepHoe ynyqmeHile nOKa.3aTeneli no
sceM napaMeTpaM B 06eI1x Ilccne.nyeMhIX rpynnax (p<0,01), KpoMe noKa.3aTemi:
)J.e3nIITenmaQIIII CJIH3IICTOH Bnaranmna, KOTOphIH B rpynne KOHTpomi: 3a 3TOT nepIIO)J. TepanIIII
He HMeJI )J.OCTOBepHoro ynyqmeHIDI (p=0,35). IlpII 3TOM B 3KCnepHMeHTaJihHOH rpynne y)l(e Ha
3-H: .neHh neqeHIIH y.nanoch .no6IIThCH noJIHoli 3nIITeJIH3a:UIIII CJIIl3IICTOH snaranmn;a. IlpII
cpaBHeHIIII H3MeHeHIIH nOKa.3aTeneli o6beKTIIBHhIX npmHaKOB 3a6oneBaHIIH Me)l()J.y rpynnaMII
6hIJIO OTMeqeHO CTaTIICTilqecKH 3HaqIIMOe npeBOCXO)J.CTBO KJIIIHilqecKoro ynyqmeHIDI
rnnepeMIIII KO)l(II (Ha 60%, P<0,01) no cpasHeHIIIO c HaqanoM neqeHIDI B 3KcnepI1MeHTaJihHOH
rpynrre.

TQ6JlUlfQ 5 - 06beKmueHaJI. OlfeHKQ no utKaJle l!JOII HQ 3-u oeHb JleIJeHuJI. (2-u euJum) e
CfJQBHeHuu c ucxoOHblMU noKmQmellJl.MU /1-u euJum).
[/QpaMempbz KoHmf)Ollb 3KcnepUMeHm
M±m YllYIJuteHue P* M±m YllY'luteHue P*
IloKpQcHeHue c!luJucmou 1,0±0,3 1,8 <0,01 0,8±0,5 2 <0,01
I'unepeMUJI. KO:JICU 0,5±0,6 1,1 <0,01 0,1±0,3 1,7 <0,01
JleuKoKCQHmopeJI. 0,4±0,5 1,2 <0,01 0,2±0,5 1,0 <0,01
J(e3numellU3QlfUJI. 0,1±0,3 0,1 0,35 0,0±0,0 0,1 <0,05
cRUJucmou
P* - cpaenenue c ucxooHblMU oaHHblMU (eu3um M2 c 6U3Umo.M Ml) .

Cne.ny10mI1M 3TarroM I1ccne.nosaHI1H HBHJiach cy6'heKTIIBHaH oueHKa rrpoHBJieHIIH

BarIIHIITa Ha 2-li .neHh nocne 3aBepmeHIIH neqeHIDI B cpaBHeHIIII c IICXO)J.HhIMII .naHHhIMII.
~aHHh!e npe,n:cTaBJieHHhie B Ta6n. 6, CBil)J.eTeJihCTBYIOT 0 TOM, qro K KOHey neqeHIDI OTMeqanoch
CTaTIICTilqeCKII 3Ha~MOe CHil)l(eHile CIIMnTOMOB II npoHBJieHIIH BarIIHIITa no BCeM nOKa.3aTemi:M
B 06eI1x rpynnax.
IlpII o6'heKTHBHOH oueHKe OKOWiaTeJihHhIX pe3y.TihTaTOB npOHBJieHIIH BarHHIITa (rn6n. 7)
oTMeqanoch cTaTI1CTI1qecKI1 3HaqHMoe Bhl3,n:oposneHI1e B 06eI1x Ilccne.nyeMhIX rpynnax. Ha
MOMeHT OKOHqaHIIH 3KCnepI1MeHTa y Bcex 60 )l(eHJnIIH 6hIJI BhICTaBJieH KJIIIHilqecKIIH )J.IlarH03 -
Bhl3)J.OpOBJieHile. IlpII 3TOM, KaKOrO-JIIl6o CTaTIICTilqecKH 3Ha~oro npeIIMymecTBa B
noKa.3aTemi:x Me)l()J.y rpyrrnaMII He oTMeqanoch. B uenoM, MO)l(HO c,n:enaTh Bhrno.n: o TOM, qro
CTaH,n:apTHOe cneuil<iiHqeCKOe npOTIIBOMI1Kpo6Hoe Jiel:J:eHile TaK)l(e KaK II neqeHile c
56
 .z:i:o6aBJiemreM BanrnaJibHOro pacTBopa H6yrrpocpeHa H3o6yTaHOJiaMMOHFUICT3THCTH'IeCKH H
KJlliHHqecKH ,llOCTOBepHO o6ecrreqirnaeT IIOJIHOe Hcqe3HOBeHHe o6oeKTHBHbIX rrpH3HaKOB
6oJie3HH K KOHizy peKOMeH,llOB3HHOro eypca JieqeHmI.
. TQ6JlUtfQ 6- Cy6oeKmU6HM OtfeHKQ np0>1,6JlellUU 6Q2UHUmQ HQ 2-ii oeHb nocJle 3Q6epweHU>l,
J1el.leHU>1, (oKOHl.lQmeflbHble pe3VflbmQmbz) no CJJQ6HeHwo c ucxooHblMU nOKQ3QmeJ1>1,MU.
IJQpaMempbl KOHmf)OJlb 3KcnepUMeHm
M±m I YllYl.lWeHue P* M±m I VllVllWeHue P*
BQ2Wla'JlbHM 6oflb 1,0 ± 0,2 0,6 0,04 0,42 ± 0,67 1,87 <0.01
BQ2uHaJZbHbzu 3yo 1,0 ± 0,2 2,7 <0,01 0,52 ± 0,57 3,58 <0.01
BQ2UHa'JlbHOe J1CJ1CeHue 1,0 ± 0,0 4,5 <0,01 0,45 ± 0,51 4,81 <0.01
BQ2UHa'JlbHble 6bzoeJ1eHU>1, 1,0 ± 0.0 7,0 <0,01 0,42 ± 0,50 7,77 <0.01
BJ1U>1,Hue HQ cnopmu6Hy10 1,0 ± 0,0 1,5 0,01 0,48 ± 0,51 1,97 <0.01
QKmU6HOCmb
BllU>l,HUe Ha COtfUGflbHYIO 1,0 ± 0,2 1,5 0,01 0,55 ± 0,57 1,29 0.001
QKmU6HOCmb
P* - cpae1-1e1-1ue c ucxoortbIMU oartrtbl.lltu (6u3um M3 c eu3umoM Ml)

Ta6JlUtfQ 7- 06oeKmU6HM OtfeHKQ U3MeHeHU>l, nOKQ3QmeJleii npU3HQK06 6oJle3HU HQ 2-ii oeHb

noc!le 3Q6epweHu>1, KypcQ J1el.leHU>1,(0KOHl.lQmeJ1bHble pe3yflbmQmbz) no cpQ6HeHu10 c HQl.la'JlOM
flel.leHU51.:
[JQpQMempbl UMeHm
M±m P* M±m 'fl l.lWeHue P*
IIoKpQCHeHue CflU3Ucmoii 0,0 ± 0,0 2,8 <0,01 0,0 ± 0,0 2,84 <0.01
I'unepeMUR KOJICU 0,0 ± 0,0 1,6 <0,01 0,0 ±0,0 1,87 <0.01
JleilK0Kcal-lmope>1, 0,0 ±0,0 1,6 <0,01 0,0 ± 0,0 1,16 <0.01
J(e:JnumeflU3QtfU>l, 0,0 ± 0,0 0,2 <0,05 0,0 ± 0,0 0,13 <0.05
CflU3ucmoii
P* - cpae1-1e1-we c ucxoortbIMU oartrtblMU (eu3um NB c eu3umoM Ml)

O.z:i:ttaKO, rrpH cy6oeKTHBHOH ou;eHKH )l(eHlIJ,HH3MH K KOHIJ.Y JieqeHH>I (pHc. 2) OTMeqeHO

,llOCTOBepHO 60JibIIIee yny~emre H Hcqe3HOBeHHe CHMIITOMOB BarHHaJibHOH 6oJIH H
. BarHHaJibHOro )l()l(eHH>I, p<0,01.
3 .

'I •··'

6 ~ '

..
s \

2 ;

I\
Q ,,

• KOHTPOflb, ynyyweH11te
• 3KCnEPll1MEHT, ynyYWeHl!le
Puc 2. Cy6oeKmU6HQ}l, OlJeHKQ U3MeHeHU}l, CUMnmOM06 HQ 2-u oeHb nocJle Jlel.leHU>l,
(oKOHl.lQmeflbHble pe3yflbmambl) no cpQeHeHu10 c Hal.la'JlOM J1el.leHw1: cpQeHeHue Mexoy
2pynnaMu.

57
 B pe3yJihTaTe rrpoBe.n;eHHOro HCCJie.n;oBaHHH ycrnHOBJieHO, qrn (rn6rr. 8) K KOHizy rreqeHHH
rrpH 061,eKTHBHOH ou;eHKe rrorryqeHHhIX pe3yJihTaTOB )J;OCTOBepHbIX pa3JIHqHH: B o6eHX
Hccrre.n;yeMhIX rpyrrrrax TaK>Ke He Ha6mo.n;arroch, p>0,05.
B xo.n;e 3KcrrepHMeHTa .D;OKa3aHo, qTO OTMeqaeTcH Bhipa)l(eHH~ J<l><l>eKTHBHOCTh BJIHHHHH
Ha cy6'heKTHBHhie IIOKa3aTeJIH rrpoHBJieHHH BarHHHTa H HeKOTOpoe BJIHHHHe Ha o6'heKTHBHbie
rrpH3HaKH 6orre3HH rrpH .n;o6aBJieHHH K CTaH.n;apTHOMY rreqeHHIO BarHHaJihHOro pacrnopa
H6yrrpo<l>eHa H3o6yTHJiaMMOHHH.

Ta6J1u4a 8 - 06beKmU6HaJl 04eHKa U3MeHeHWl noKa3ame!leu npu3HaK06 6o!le3HU Ha 2-u OeHb

noc!le 3a6epmeHWl Kypca Jle'l,eHWl (oKOH'l,amellbHbte pe3yllbmambt) no cpa6Heuwo c HQ'l,QJlOM
Jle'l,eHWl : cpa6Heuue Me:>IC01y 2ovnnaMu.
llpU3HQKU 6o!le3HU KoumpOllb 3KcnepUMeHm (P)
llOKf)QCHeHue CJlU3UCmou 2,8 2,84 >0,05
I'unepeMWl KOJICU 1,6 1,87 >0,05
JleuKoKcaumopeJI, 1,6 1,16 >0,05
J(e3numeJ1u3a-4Wl CllU3ucmou 0,2 0,13 >0,05

TaKHM o6pa3oM, BarHHaJihHhIH pacrnop H6yrrpo<l>eHa H3o6yTHJiaMMOHHH MO)l(eT HBJIHThCH

u;eHHhIM H rrepcrreKTHBHhIM cpe.n;CTBOM )J;JIH o6ecrreqeHHH 6bICTPOro H HaJJ;e)l(HOro KOHTpom1
CHMIITOMaTHKH BarHHHTOB, He3aBHCHMO OT CTerreHH TH)l(eCTH 3a6orreBaHHH.
Cnuco1< J1umepamypb1:
1. Kupa E. <P. HopMaJlbHaR MUKpo<fJ;wpa noROBbLX nymeu J1CeHUfUH [TeKcm] I Kupa E. <P. II
I'u11eKoJ102u5l.. Hat{UOHaJlbHoe pyKoeoocmeo. - M: I'30TAP-Meoua, 2013. -I'll. 10. - C. 366-369.
2. J(a1111bze HJ.IOMuJ(. BocnaJ1umeRbHbLe 3a60J1eea11U5l. J/CeHCKU:X noROBbLX op2a11oe 2011-2015 22.
[TeKcm] II Kbzp2bl3CKa5l. Pecny6RuKa, 2016. -12 c.
3. Women's health {3J1eKmpo1111b1u pecypc] I World Health Organization official site II Health
topics, 2016.
4. Callahan T.L. Vaginal infections [Text] I Callahan T.L., Caughey A.B. II Blueprints Obstetrics
& Gynecology, Lippincott Williams & Wilkins (Wolters Kluwer) . - Philadelphia (PA, USA) , 2013. - P.11. -
Ch.16. - pp. 221-223.
5. Anderson MR. Evaluation of vaginal complaints [Text] I Anderson MR. II JAMA, 2004. -
Mar 17. - Ch. 291 (11) . - pp. 1368-79.
6. Schwiertz A. Throwing the dice for the diagnosis of vaginal complaints? [Text] I Schwiertz A.,
Taras D., Rusch K., RuschV II Ann Clin Microbial Antimicrob, 2006. - Feb 17. - Ch.5. - p .4.
7. Egan ME. Diagnosis ofvaginitis [Text] I Egan ME., Lipsky MS. II Am Fam Physician, 2000.
- Sep 1. - Ch. 62(5) . - pp. 1095-104.
8. Hoffman B.L. Gynecologic Infection [Text] I Hoffman B.L. et al. II Williams Gynecology. -
McGraw-Hill Education: New York (NJ, USA), 2016. - Sect. I . - pp. 60-61.
9. Sobel JD. Vulvovaginal candidosis [Text] I Sobel JD. II Lancet, 2007. - Jun 9. - pp.369.
10. Tong I.L. Bacterial Vaginosis [Text] I Tong I.L., Garry K.A . II The 5 Minute Consult Clinical
Companion to Women's Health. Lippincott Williams & Wilkins : Philadelphia (PN, USA) , 2007. - p .40.
11. Boyd E. Vaginitis: Bacterial Vaginosis [Text] I Boyd E., Peipert J II The 5-Minute Obstetrics
& Gynecology Consult. Lippincott Williams & Wilkins : Philadelphia (PN, USA) , 2008. - Sect.II. - p.205.
12. Kumaraswami T.N Vaginitis and Vaginosis [Text] I Kumaraswami T.N, Caggiano ME. II
The 5-Minute Clinical Consult. Lippincott Williams & Wilkins: Philadelphia (PN, USA) , 2012. - 20th Ed.
- p .1397.
13. Workowski KA . Sexually transmitted diseases treatment guidelines [Text] I Workowski K. ,
Berman S. II Centers for Disease Control and Prevention (CDC). MMWR Recomm, 2010. - Dec
17.59(RR-12). -110 p.
14. De Sanctis V Diagnosi e trattamen to dellepi ucomuni vulva vaginiti nell 'eta ado/es cenziale
[Text] I De Sanctis V II Rivista/taliana di Medicinadell 'Adolescenza, 2005. - Ch. 3(1). -p. 25-31.
15. Facchinetti F. Vaginiti e trattamento antinfi ammatoriotopico. Potenzialitaterapeutiche di
ibuprofeneisobutanolammonioapplicato per mezzo di un device innovativo [Text] I Facchinetti F. II
Rivista di Ostetricia Ginecologia Pratica e Medicina Perinatale, 1999. - Ch. 14(2). -p.3.

58
 16. Lanza P. Efficacy and safety of a 7-day course of miconazole associated with
ibuprofenisobutanolammonium compared to therapy with miconazole alone in mycotic vaginitis [Text] I
Lanza P., Corea D., Mastrantonio P. II Gazzetta Medica ltaliana Archivio per le Scienze Mediche, 2000.
-April. 159(2). -p. 71-8.
17. Milani M Vaginal use of Ibuprofen isobutanolammonium (ginenorm) : efficacy, tolerability,
and pharmacokinetic data: a review of available data [Text] I Milani M, Iacobelli P. II ISRN Obstet
Gynecol, 2012. - Ch. 673,131. -p. 1-6.
18. Sullivan G.M Analyzing and Interpreting Data From. Likert-Type Scales [Text] I Sullivan
G.M , ArtinoA.R. II JGrad Med Educ, 2013. -Dec. 5 (4). -p. 541-542.
19. Stinson J.N. Systematic review of the psychometric properties, interpretability and feasibility
of self-report pain intensity measures for use in clinical trials in children and adolescents [Text] I Stinson
J., Kavanagh T., YamadaJ. eta/. II Pain, 2006. - Nov. 125(1-2). -p. 143-57.
20. Witt A. Monthly itraconazole versus classic homeopathy for the treatment of recurrent
vulvovaginal candidiasis: a randomised trial [Text] I Witt A. et al. II BJOG, 2009. - Oct; 116 (11). -
p.505.
21. Todd K.H. The minimum clinically important difference in physician-assigned visual analog
pain scores [Text] I Todd K.H., Funk J.P. II AcadEmerg Med, 1996. - Feb. 3(2). -p. 142-6.
22. Pickard A.S. Estimation of minimally important differences in EQ-5D utility and VAS scores
in cancer [Text] I Pickard A.S. et al. II Health Qua/ Life Outcomes, 2007. - Ch.5. - p. 70.
23. Bodian CA . The visual analog scale for pain: clinical significance in postoperative patients
[Text] I Bodian CA . et al. II Anesthesiology, 2001. -Dec. 95(6): 1356. - p.61.
24. Durham T.A . Sample size for continuous outcomes in superiority trials [Text] I Durham T.A .,
Turner J.R. II Introduction to Statistics in Pharmaceutical Clinical Trials. Pharmaceutical Press: London
(UK), 2008. -Ch.12. -pp.173-174.
25. Candiani G.B. Therapeutic effect and tolerability of the formula "SC 501" packets of 1 g in
inflammat01y processes of the vulvovaginal complex (controlled study vs. placebo) lstitutiClinici di
perfezionamento ''L. Mangiagalli" Obstetrics and Gynecology Clinic {:J!leKmpoHHbltl pecypc] I Candiani
G.B. II University of Milan. Prima Clinica, 1987.

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