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1. Cazzola M., Calzetta L., Page C. et al. Influence of N-acetylcysteine on chronic bronchitis or COPD exacerbations: a meta-analysis // Eur.
Respir. Rev. 2015. V. 24. P. 451461.
2. Decramer M., Rutten-van Molken M., Dekhuijzen P. et al. Effects of N-acetylcysteine on outcomes in chronic obstructive pulmonary
disease (Bronchitis Randomized on NAC Cost-Utility Study, BRONCUS): a randomised placebo-controlled trial // Lancet. 2005. V. 365.
P.15521560.
3. Rubin B. Aerosol medications for treatment of mucus clearance Disorders // Respir. Care. 2015. V. 60. P. 825829.
4. Poole P., Black P. Oral mucolytic drugs for exacerbations of chronic obstructive pulmonary disease: systematic review // BMJ. 2001.
V.322. P. 12711274.
5. Tam J., Nash E., Ratjen F. et al. Nebulized and oral thiol derivatives for pulmonary disease in cystic fibrosis // Cochrane Database Syst.
Rev. 2013. 7. CD007168.
6. . . // . 2012. 2.
. 6365.
7. Johnson K., McEvoy C., Naqvi S. et al. High-dose oral N-acetylcysteine fails to improve respiratory health status in patients with chronic
obstructive pulmonary disease and chronic bronchitis: a randomized, placebo-controlled trial // Int. J. Chron. Obstruct. Pulmon. Dis. 2016.
V.11. P. 799807.
8. Stephan U. N-Acetylcystein als Mukolytikum in Klinik und Praxis // Atemwegs-und Lungenkrankheiten. 1991. V. 17, Suppl 1.
P.35.
9. Rubin B. Mucolytics, expectorants, and mucokinetic medications // Respir. Care. 2007. V. 52. P. 859865.
10. Rodenstein D., DeCoster A., Gazzaniga A. Pharmacokinetics of oral acetylcysteine: absorption, binding and metabolism in patients with
respiratory disorders // Clin. Pharmacokinet. 1978. V. 3. P. 247254.
11. . . . .: , 1977.
12. . . -
/ . . ... : . . - . . . , 1971.
13. . ., . ., . . . N- // . . 1972. 12. . 9599.
14. Tse H., Tseng C. Update on the pathological processes, molecular biology, and clinical utility of N-acetylcysteine in chronic obstructive
pulmonary disease // Int. J. Chron. Obstruct. Pulmon. Dis. 2014. V. 9. P. 825836.
15. Jargin S. On the use of carnosine and antioxidants // J. Intercult. Ethnopharmacol. 2016. V. 5. P. 317319.
: 117198, . , . -, 6
.: (495) 9516788, e-mail: sjargin@mail.ru
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